Influence of Different Types of Corticosteroids on Heart Rate Variability of Individuals with Duchenne Muscular Dystrophy—A Pilot Cross Sectional Study

Dias, Rodrigo Martins; Hoshi, Rosângela Akemi; Vanderlei, Luiz Carlos Marques; Monteiro, Carlos Bandeira de Mello; Alvarez, Mayra Priscila Boscolo; Crocetta, Tânia Brusque; Grossklauss, Luis Fernando; Fernani, Déborah Cristina Gonçalves Luiz; Dantas, Maria Tereza Artero Prado; Martins, Fabiana Paula Almeida; Garner, David M.; Abreu, Luíz Carlos de; Ferreira, Celso; Silva, Talita Dias da

doi:10.3390/life11080752

Cited by 6 publications

(4 citation statements)

References 59 publications

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“…Moreover, immunosuppressive agents could potentially affect autonomic function [ 37 ], thereby increasing the potential risk of arrhythmia, cardiac hypertrophy, and abnormal vascular remodeling [ 38 ]. Corticosteroids hold the potential to impact cardiovascular autonomic function, resulting in improved responses in terms of sympathovagal balance (Prednisone/Prednisolone), as observed in patients with Duchenne Muscular Dystrophy [ 39 ]. One study, using echocardiography techniques including Tissue Doppler imaging, found that before pyridostigmine intake, compared to controls, MG patients exhibited lower early diastolic AV-plane velocity and diminished peak systolic strain.…”

Section: Discussionmentioning

confidence: 99%

Altered Cardiac Autonomic Regulation in Individuals with Myasthenia Gravis—A Systematic Review and Meta-Analysis

Zawadka-Kunikowska,

Rzepiński,

Tafil-Klawe

et al. 2023

Neurology International

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The aim of this systematic review with meta-analysis was to determine differences in cardiovascular autonomic parameters between patients with myasthenia gravis (MG) and healthy controls (HCs). Two reviewers searched four electronic databases, namely PubMed, Web of Science, EMBASE, and SCOPUS, from database inception to 7 July 2023 for studies investigating cardiovascular autonomic parameters in MG vs. HCs. A random-effects meta-analysis was performed to compute Hedges’ g ± 95% confidence intervals (CI). Out of a total of 2200 records, 8 observational studies with a sample size of 301 patients with MG and 454 HCs were included in the systematic review. Meta-analysis revealed lower values of expiration/inspiration ratio (g = −0.45, I2 = 74.7), baroreflex sensitivity (g = −0.56, 95%CI −0.80, −0.33; I2 = 0.3), percentage of adjacent NN intervals differing by more than 50 ms (g = −1.2, I2 = 82.8), square root of the mean of squared differences between successive beat intervals (g = −1.94, I2 = 95.1), mean of the standard deviations of all NN intervals (g = −0.83, 95%CI −1.37, −0.28; I2 = 55.5), and high frequency of HRV during tilt (g = −0.75, 95%CI −0.11, −0.39; I2 = 0). MG patients vs. HCs had higher systolic blood pressure (g = 0.39; I2 = 56.1), sympathovagal balance at rest/during tilt (LF/HF-RRIsupine, g = 0.44; I2 = 0; LF/HF-RRItilt, g = 0.86; I2 = 0; LF/HFtilt, g = 0.40; I2 = 0). As a group, MG patients have altered cardiac autonomic function, including decreased parasympathetic function, lower baroreflex sensitivity, and higher sympathovagal balance at rest and during orthostatic challenges.

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Section: Discussionmentioning

confidence: 99%

Altered Cardiac Autonomic Regulation in Individuals with Myasthenia Gravis—A Systematic Review and Meta-Analysis

Zawadka-Kunikowska,

Rzepiński,

Tafil-Klawe

et al. 2023

Neurology International

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“…The non-linear analysis was performed using the Symbolic Dynamics Analysis method, with four indices [42], measured by grouping the patterns with 3 symbols into four types of clusters; the rate of occurrence for each pattern was defined as %0 V (no variation) reflecting only sympathetic modulation, %1 V (one variation) reflecting global variability by sympathetic and parasympathetic modulation, %2 LV (two like variations), and %2 UV (two unlike variations), both of which exclusively reflect parasympathetic modulation (vagal) [43][44][45].…”

Section: Heart Rate Variability (Hrv)mentioning

confidence: 99%

“…Although HRV is commonly analyzed using linear models, interest in nonlinear methods (symbolic analysis) has increased in recent years [43]. This methodology differs from standard approaches because it considers the qualitative properties of a single heart rate series [61].…”

Section: Comparison Of Hrv Between Groups and Different Agesmentioning

confidence: 99%

Heart Rate Variability during Virtual Reality Activity in Individuals after Hospitalization for COVID-19: A Cross-Sectional Control Study

et al. 2023

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(1) Background: COVID-19 can lead to many complications, including cardiorespiratory complications and dysautonomia. This can be assessed by heart rate variability (HRV), which reflects the autonomic nervous system. There are different possibilities for physical rehabilitation after COVID, one of which that has been growing fast is the use of Virtual reality (VR) for rehabilitation. VR may represent an innovative and effective tool to minimize deficits that could lead to permanent disabilities in patients of outpatient rehabilitation services. The aim of this protocol is to establish whether practicing a task using a VR game with body movements influences physiological variables, such as heart rate, HRV, oxygen saturation, blood pressure, and perceptual variables during exercise in individuals post-hospitalization for COVID. (2) Methods: This cross-sectional study evaluated individuals divided into two groups, a post-hospitalization for COVID-19 group and a healthy control group. Subjects underwent one session of a VR task, and physiological variables, including HRV, were measured during rest, VR activity, and recovery. In addition, considering the influence of age in HRV and the impact of COVID-19, we divided participants by age. (3) Results: In all HRV indices and in both groups, an increase in sympathetic and a decrease in parasympathetic activity were found during VR. Additionally, the older post-COVID-19 group performed worse in non-linear indices, peripheral oxygen saturation, and rating of perceived exertion (RPE). (4) Conclusions: The VR game positively affects physiological variables and can therefore be utilized as a secure physical activity in both healthy individuals and individuals after hospitalization for COVID-19. COVID-19 affects the autonomic nervous system of older patients’ post-hospitalization, which may be partly due to a higher BMI and the reduced exercise capacity in this population, affecting their ability to perform exercise activities. Other important observations were the higher RPE in COVID-19 patients during and after exercise, which may reflect altered physiological and autonomic responses. Taken together with the high reporting of fatigue after COVID-19, this is an important finding, and considering that RPE is usually lower during VR exercise compared to non-VR strengthens the potential for the use of VR in COVID-19 patients.

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“…Although no cure exists for muscular dystrophy, current treatments aim to manage symptoms and improve quality of life. These treatments encompass physical therapy to maintain muscle strength and flexibility, medications to slow muscle degeneration, and sometimes surgery to correct deformities or relieve tight muscles (1)(2)(3)(4)(5)(6)(7). This patient education book offers a comprehensive overview of muscular dystrophy, covering its types, genetic factors, symptoms, diagnostic processes, and management and treatment options, all explained in simpler terms.…”

Section: Introductionmentioning

confidence: 99%

Muscular Dystrophy: Patient Education

2024

Muscular Dystrophy

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Muscular dystrophy is a group of inherited diseases that lead to muscle weakness and a gradual loss of muscle mass. This condition can make everyday activities like walking, climbing stairs, or holding objects challenging, as it can affect different muscles throughout the body. The main issue in muscular dystrophy is the insufficient production of dystrophin, a protein crucial for maintaining muscle tissue integrity and function. Without enough dystrophin, muscles progressively weaken over time. Muscular dystrophy can manifest at any age and varies widely in severity and progression, depending on the specific type. Although there is no cure for muscular dystrophy, various treatments and therapies are available to help manage symptoms and improve quality of life. These options include physical therapy, medications, nutritional support, and in some cases, surgery. This patient education book provides an extensive overview of muscular dystrophy, covering its types, genetics, symptoms, diagnosis, and management in simpler terms.

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Influence of Different Types of Corticosteroids on Heart Rate Variability of Individuals with Duchenne Muscular Dystrophy—A Pilot Cross Sectional Study

Cited by 6 publications

References 59 publications

Altered Cardiac Autonomic Regulation in Individuals with Myasthenia Gravis—A Systematic Review and Meta-Analysis

Altered Cardiac Autonomic Regulation in Individuals with Myasthenia Gravis—A Systematic Review and Meta-Analysis

Heart Rate Variability during Virtual Reality Activity in Individuals after Hospitalization for COVID-19: A Cross-Sectional Control Study

Muscular Dystrophy: Patient Education

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