Influence of Disintegrant on Properties of Fast Disintegrating Tablet Containing Xylitol

Abstract

Disintegrants had influence on disintegration time and dissolution for fast disintegrating tablet (FDTs). Therefore, the purpose of this study was to evaluate the effect of disintegrant type on the characteristics of FDTs. In this research, the tablets were fabricated by direct compression with the compression force of 1.5 tons and using the different disintegrants components (chitin, chitosan, xylitol, microcrystalline celluloses, white bentonite and magnabite F). The physical properties of these tablets were determined. The xylitol tablets were rapidly disintegrated within 7+1 s, whereas that of the others was longer than 30 mins. The tablets containing the mixture of xylitol and other materials were subsequently fabricated since the hardness of the xylitol tablet was very poor. The disintegration time and wetting time of tablets containing 9:1 xylitol:Avicel PH101 was shorter than that of the others. The contact angle of tablets containing xylitol and Avicel PH101 at the ratio of 9:1 was lowest and surface free energy (SFE) of them was highest compared with the other formula. Moreover, scanning electron microscope (SEM) displayed that xylitol and tablets containing 9:1 xylitol:Avicel PH101 had no disordered arrangement, therefore it could promote the disintegrating property effectiently.