Influence of Dorzolamide on Corneal Endothelium

Comparative Study of Central Corneal Thickness Using Fourier-Domain Optical Coherence Tomography Versus Ultrasound Pachymetry in Primary Open-Angle Glaucoma

“…20,21 Wu et al 22 demonstrated that betaxolol, brimonidine, dorzolamide, dipivefrin, latanoprost, and unoprostone induced cytotoxicity in bovine corneal endothelial cultured cells. Otherwise in the study of Inoue et al, 23 topical application of dorzolamide altered the endothelial function by reducing the endothelial pumping function, thereby increasing the corneal stroma water content. Furthermore, it has been suggested that prostaglandin analogs may alter the extracellular matrix of the corneal stroma via the upregulation of matrix metalloproteinases.…”

Effect of Dorzolamide Hydrochloride on Central Corneal Thickness in Humans With Cornea Guttata

“…11,12,15 Kaminski et al 13 reported minor increases in CCT after 1 day of dorzolamide treatment that were not statistically significant. In contrast, studies showed small but statistically significant changes in long-term 17,21 and short-term 18 use of dorzolamide. All these studies, apart from our previous study, used optical slitlamp pachymetry or conventional ultrasound pachymetry for CCT measurements.…”

“…[10][11][12][13][14][15] In 1999, Konowal et al 16 performed a retrospective study with 9 eyes of 9 patients who developed irreversible corneal decompensation during dorzolamide therapy. In 2003, Inoue et al 17 detected a statistically significant increase in central corneal thickness (CCT) after long-term use of dorzolamide. However, the CCT measuring methods in these studies did not provide the highest precision because they used optical slitlamp pachymetry or conventional ultrasound pachymetry.…”

Short-Term Effect of Topical Dorzolamide Hydrochloride on Intrastromal Corneal Pressure in Rabbit Corneas In Vivo

“…This finding is consistent with the reported cases of dorzolamide-induced corneal edema in susceptible patients [5][6][7] and with the finding that inhibiting carbonic anhydrase in the corneal endothelium causes a 50% decrease in the endothelial fluid transport 15,16 and corneal swelling. 16 Other ways of evaluating endothelial function, such as measuring the CCT, also have shown that these drugs seem to increase the CCT values when administered topically, [9][10][11]17 suggesting that the water content in treated corneas probably increases because of the decreased endothelial function induced by these drugs. Nevertheless, because the amount of increase in corneal thickness was small, the number of eyes needed to be analyzed to reach statistical significance was relatively large.…”

“…Some investigators have reported that there was a slight but significant increase in CCT in eyes treated with dorzolamide. [9][10][11] Another way to measure the endothelial function in vivo is to measure the intrastromal corneal pressure (ICP), formerly known as corneal imbibition pressure, which has a negative value under physiologic conditions. [12][13][14] The amount of negative pressure in the corneal stroma is likely to correlate with the endothelial function.…”