Influence of doxazosin on biosynthesis of S100A6 and atrial natriuretic factor peptides in the heart of spontaneously hypertensive rats

Kasacka, Irena; Piotrowska, Żaneta; Filipek, Anna; Majewski, Mariusz

doi:10.1177/1535370215611972

Cited by 7 publications

(7 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are many reports showing that S100A6 level increases under stress conditions such as ischemia [ 123 ], mechanical force [ 124 ], irradiation [ 24 ], oxidative stress [ 125 ], hypertension [ 126 ] or kainic acid treatment [ 127 ]. All these conditions may lead to cell apoptosis and inflammation followed, depending on the extent of tissue damage, by regeneration [ 128 ].…”

Section: Structural Aspects Of S100a6—ligand Interactionsmentioning

confidence: 99%

S100A6 Protein—Expression and Function in Norm and Pathology

Leśniak

Filipek

2023

IJMS

Self Cite

View full text Add to dashboard Cite

S100A6, also known as calcyclin, is a calcium-binding protein belonging to the S100 protein family. It was first identified and purified more than 30 years ago. Initial structural studies, focused mostly on the mode and affinity of Ca2+ binding and resolution of the resultant conformational changes, were soon complemented by research on its expression, localization and identification of binding partners. With time, the use of biophysical methods helped to resolve the structure and versatility of S100A6 complexes with some of its ligands. Meanwhile, it became clear that S100A6 expression was altered in various pathological states and correlated with the stage/progression of many diseases, including cancers, indicative of its important, and possibly causative, role in some of these diseases. This, in turn, prompted researchers to look for the mechanism of S100A6 action and to identify the intermediary signaling pathways and effectors. After all these years, our knowledge on various aspects of S100A6 biology is robust but still incomplete. The list of S100A6 ligands is growing all the time, as is our understanding of the physiological importance of these interactions. The present review summarizes available data concerning S100A6 expression/localization, interaction with intracellular and extracellular targets, involvement in Ca2+-dependent cellular processes and association with various pathologies.

show abstract

Section: Structural Aspects Of S100a6—ligand Interactionsmentioning

confidence: 99%

S100A6 Protein—Expression and Function in Norm and Pathology

Leśniak

Filipek

2023

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…CASP1 [185], FOXP3 [186], SOCS1 [187], GATA6 [188], IRF7 [189], POSTN (periostin) [190], CYP19A1 [191], CD36 [192], LYN (LYN proto-oncogene, Src family tyrosine kinase) [193], CD4 [194], LEPR (leptin receptor) [195], AR (androgen receptor) [196], FOXO1 [197] and PON2 [198] are a potential biomarkers for the detection and prognosis of PCOS. Udjus et al [199] Benjafield et al [200], Shetty et al [58], Kassan et al [201], Wetzl et al [202], Le Hiress et al [203], Pal-Ghosh et al [204], Niu, [205], Fan et al [206], Deng et al [207], Chen et al [208], Sardo et al [209], Seidel et al [210], Zhu et al [211], Omura et al [212], Hu et al [213], Castoldi et al [214], Yoshida et al [215], Palao et al [216], Kušíková et al [217], Decharatchakul et al [218], Ahmed et al [219], Merklinger et al [220], Lei et al [146], Liu et al [221], Chen et al [222], Tan et al [223], Shi et al [224], Ikonnikova et al [225], Shimodaira et al [226], Pravenec et al [227], Zhang et al [228], Shah et al [229], Cicekliyurt and Dermenci [230], Ong et al [98], Nowzari et al [163], Kim et al [231], Bonafiglia et al [232], Selle et al [233],Yoo et al [234], Kasacka et al [235], Wang et al [236], Huang et al [237], Caceres et al [238], Lei et al [239], Lu et al [240], Cui et al [241], Xiao et al [242], Hiramatsu et al [243], Oliver et al [244], Grabowski et al [245], Zhu et al [246] and Li et al [247] demonstrated that the altered expression of CASP1, EDNRA (endothelin receptor type A), F2RL1, FOXP3, TIMP4, CD74, PLK1, TGFB1, GATA6, IRF7, IRF9, BGN (biglycan), C...…”

Section: Discussionmentioning

confidence: 99%

The Identification of Key Genes and Biological Pathways in Polycystic Ovary Syndrome and its Complications by Next Generation Squancing (NGS) and Bioinformatics Analysis

Vastrad¹,

Vastrad²

2023

Preprint

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is is associated with infertility, obesity, insulin resistance, hyperinsulinemia, type 2 diabetes mellitus, hypertension, cardiovascular problems, neurological and psychological problems and cancer. The specific mechanism of PCOS and its complications remains unclear. The aim of this study was to apply a bioinformatics approach to reveal related pathways or genes involved in the development of PCOS and its complications. The next generation squancing (NGS) datset GSE199225 was downloaded from the gene expression omnibus (GEO) database. Differentially expressed gene (DEG) analysis was performed using DESeq2. The g:Profiler was utilized to analyze the functional enrichment, gene ontology (GO) and REACTOME pathway of the differentially expressed genes. A protein-protein interaction (PPI) network was constructed and module analysis was performed using HiPPIE and cytoscape. The miRNA-hub gene regulatory network and TF-hub gene regulatory network were also constructed for research. The expression of the hub genes was validated using receiver operating characteristic (ROC) curve analysis. We have identified 957 DEGs in total, including 478 up regulated genes and 479 down regulated gene. GO and REACTOME illustrated that DEGs in PCOS were significantly enriched in regulation of molecular function, developmental process, interferon signaling and platelet activation, signaling and aggregation. Finally, through analyzing the PPI network, modules, miRNA-hub gene regulatory network and TF-hub gene regulatory network, we screened hub genes HSPA5, PLK1, RIN3, DBN1, CCDC85B, DISC1, AR, MTUS2, LYN and TCF4 by the Cytoscape software. This study uses a series of bioinformatics technologies to obtain hug genes and key pathways related to PCOS and its complications. These analysis results provide us with novel ideas for finding biomarkers and treatment methods for PCOS and its complications.

show abstract

“…S100A6 is a member of the S100 protein family ( 15 ). S100A6 has a number of biological functions, including participating in the degradation and ubiquitination of β-catenin, promoting apoptosis, interacting with extracellular matrix proteins, enhancing cell metabolism and skeleton depolymerization, participating in endocytosis and exocytosis, adjusting enzyme activity, inhibiting protein kinase C-mediated phosphorylation and participating in gene transcription ( 16 , 17 ). A number of studies have demonstrated that S100A6 is also associated with the occurrence and development of tumors and is upregulated in several tumors, including ovarian cancer, colorectal cancer, pancreatic cancer, liver cancer, malignant melanoma and osteosarcoma ( 18 , 19 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of differentially expressed proteins in the gastric mucosal atypical hyperplasia tissue microenvironment

Zhang

Liu

et al. 2018

Oncol Lett

View full text Add to dashboard Cite

In the present study, the interaction of proteins in the microenvironment of gastric mucosal atypical hyperplasia was analyzed. The stromata of normal gastric mucosa (NGM) and gastric mucosal atypical hyperplasia (GMAH) tissues were purified with laser capture microdissection (LCM). The differentially expressed GMAH proteins of the NGM and GMAH tissues were identified by quantitative proteomic techniques with isotope labeling. The cross-talk between differentially expressed proteins in NGM and GMAH tissues was then analyzed by bioinformatics. There were 165 differentially expressed proteins identified from the stromata of NGM and GMAH tissues. Among them, 99 proteins were upregulated and 66 were downregulated in GMAH tissue. The present study demonstrated that these proteins in gastric mucosal atypical hyperplasia were involved in cancer-associated signaling pathways, including the p53, mitogen-activated protein kinase (MAPK), cell cycle and apoptosis signaling pathways, and were involved in cellular growth, cellular proliferation, apoptosis and the humoral immune response. The results of the present study suggest that the 165 differentially expressed proteins, including S100 calcium-binding protein A6 (S100A6) and superoxide dismutase 3 (SOD3) in the microenvironment of gastric mucosal atypical hyperplasia, are involved in the p53, MAPK, cell cycle and apoptosis signaling pathways, and serve a function in the pathogenesis of gastric cancer.

show abstract

Influence of doxazosin on biosynthesis of S100A6 and atrial natriuretic factor peptides in the heart of spontaneously hypertensive rats

Cited by 7 publications

References 48 publications

S100A6 Protein—Expression and Function in Norm and Pathology

S100A6 Protein—Expression and Function in Norm and Pathology

The Identification of Key Genes and Biological Pathways in Polycystic Ovary Syndrome and its Complications by Next Generation Squancing (NGS) and Bioinformatics Analysis

Identification of differentially expressed proteins in the gastric mucosal atypical hyperplasia tissue microenvironment

Contact Info

Product

Resources

About