Influence of drugs on vitamin D and calcium metabolism

Abstract

In the past, interactions between drugs and vitamin D have received only little or no attention in the health care practices. However, since more and more drugs are used for the treatment of patients, this topic is increasingly relevant. Several drugs can interfere with the vitamin D and bone metabolism. Drugs that activate the pregnane X receptor can disrupt vitamin D metabolism and vitamin D function. Beside this, the medication oriented supplementation of vitamin D can ameliorate the pharmacologic action of some drugs, such as bisphosphonates, cytostatics and statins.

Association between circulating 25-hydroxyvitamin D levels and medication use in patients scheduled for cardiac surgery

“…It has been assumed that several drugs may interfere with vitamin D metabolism and could therefore influence vitamin D status [12]. Evidence-based recommendations of CVD therapy include a variety of medications such as diuretics, beta-blockers, antiarrhythmics, calciumchannel blockers, statins and angiotensin-converting enzyme (ACE)-inhibitors or angiotensin receptor (AT) blockers [13,14].…”

Validation of a food frequency questionnaire to determine vitamin D intakes using the method of triads

“…Exclusion criteria for the study were: individuals with a diagnosed medical condition or on medication known to interfere with vitamin D metabolism, such as carbamazepine used to treat epilepsy (22) , and anyone who had been on a sun holiday after the preceding September. Participants were invited to attend two appointments for data collection.…”

Active Vitamin D (1,25 Dihydroxyvitamin D) Is Associated With Chronic Pain in Older Australian Men: The Concord Health and Ageing in Men Project

“…Statins.-Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors are commonly used medicines in older people and are known to interfere with the vitamin D metabolism (28). Therefore, it was important to include the use of statins in this analysis.…”