Influence of drying conditions of zirconium molybdate gel on performance of 99mTc gel generator

Davarpanah, Mohammad Reza; Nosrati, S. Attar; Fazlali, M.; Boudani, M. Kazemi; Khoshhosn, H. A.; Maragheh, Mohammad Ghannadi

doi:10.1016/j.apradiso.2009.06.011

Cited by 21 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The 99m Tc-elution performance of the gel is assessed based on the following important factors: the 99m Tc elution efficiency, the 99 Mo breakthrough in the 99m Tc eluate, the gel synthesis conditions such as the molar ratios of zirconium to molybdenum, the drying conditions i.e. time, temperature, and atmosphere of the gel [40][41][42][43][44]. Variation of the photon energy could cause the formation of other radionuclides as impurities from the isotopes of zirconium and thus the shielding would have to be designed accordingly.…”

Section: Resultsmentioning

confidence: 99%

Preparation of 99Mo from the 100Mo(γ, n) reaction and chemical separation of 99mTc

Gopalakrishna¹,

Naik

Suryanarayana

et al. 2015

J Radioanal Nucl Chem

View full text Add to dashboard Cite

The radionuclide 99 Mo has been prepared by 100 Mo(c, n) reaction using two types of natural molybdenum compound (molybdenum trioxide and zirconium molybdate gel) with the bremsstrahlung end-point energies of 10 and 15 MeV. After the equilibrium, 99m Tc was separated as NaTcO 4 from the irradiated samples using two different chemical procedures to examine the chemical yield. The separated Na[ 99m Tc]TcO 4 from the ZrMo gel has the 99Mo breakthrough of \10 -4 %, radiochemical purity[99 % as well as chemical impurities of Al, Mo and Zr \ 10 ppm. The estimation of 99 Mo and 99m Tc was done by using off-line c-ray spectrometric technique. The chemical yield of the separated 99m Tc from the dissolved molybdenum trioxide is 70.7-75.2 %, whereas in the undissolved zirconium molybdate gel, it is 19.1-43 %. The second method is preferable because it is user friendly in hospital radiopharmacy throughout the shelf-life.Keywords Medical isotope 99 Mo-9m Tc Á 100 Mo(c,n) reaction Á Molybdenum trioxide Á Zirconium molybdate gel Á Off-line c-ray spectrometric technique Á Chemical yield

show abstract

Section: Resultsmentioning

confidence: 99%

Preparation of 99Mo from the 100Mo(γ, n) reaction and chemical separation of 99mTc

Gopalakrishna¹,

Naik

Suryanarayana

et al. 2015

J Radioanal Nucl Chem

View full text Add to dashboard Cite

show abstract

“…There was a weight loss of 13.9% in the temperature range from 40 to 311 ∘ C due to the loss of physical adsorbed and lattice water. An exothermic peak was observed at 62 ∘ C followed by an endothermic one at 78 ∘ C. A shallow broad endothermic peak was observed at 244 ∘ C. The presence of lattice water with a suitable amount in the gel material facilitates the eluent diffusion [43]. There was only a small weight loss of 1.3%, in the temperature range of 338-600 ∘ C, may be due to loss of the structural water by slow diffusion from gel interior [44][45][46][47].…”

Section: Appearance Granular Colormentioning

confidence: 93%

Preparation and performance of ⁹⁹Mo/^99mTc chromatographic column generator based on zirconium molybdosilicate

et al. 2015

View full text Add to dashboard Cite

Zirconium molybdosilicate (ZrMoSi) gel prepared using 99 Mo radiotracer via peroxo route was used as a base material for 99 Mo/ 99m Tc column generator. The 99m Tc elution yield and 99 Mo breakthrough in the eluate were studied as a function of the pH-value of gel precipitation, gel drying temperature and Zr : Mo : Si molar ratio. Precipitation pH-value of 2, drying temperature of 100 ∘ C and Zr : Mo : Si molar ratio of 0.5 : 0.5 : 1 were found to be the optimum conditions achieving 99m Tc elution yield of 82% and 99 Mo breakthrough of 1.0 × 10 −3 %.The gel prepared with the optimum conditions was characterized by BET surface area and pore size analyzer, IR spectroscopy, thermal analysis (TGA and DTA), XRD, XRF and FESEM. Technetium-99m eluted from the optimum ZrMoSi 99 Mo/ 99m Tc generator was found to have a high radiochemical purity (98% as 99m TcO − 4 ) and chemical purity meeting criteria of clinical grade.

show abstract

“…through the gel material during elution. 22 In the range of 200-800°C, there was another weight loss of 4.1% due to decomposition of the gel material to cerium, molybdenum and tellurium oxides, in addition to subsequent sublimation of molybdenum oxide. 21,23 The thermal gravimetric behavior of CeTeMo gel resembles to a great extent that of cerium(IV) molybdate (CeMo) gel.…”

Section: 18-21mentioning

confidence: 99%

Preparation and characterization of cerium(IV) tellurium molybdate gel and its application as a bed for chromatographic <sup>99</sup>Mo/<sup>99m</sup>Tc generator

El-Amir

Mostafa

Ramadan

2014

Journal of Nuclear and Radiochemical Sciences

View full text Add to dashboard Cite

Cerium(IV) tellurium molybdate was prepared as a new gel bed for chromatographic 99 Mo/ 99m Tc generator. The gel material prepared with the optimum conditions was characterized with IR spectroscopy, thermal analysis, XRD, EDX and FESEM. The highest precipitation yield of 99 Mo within the formed gel was found to be 97.6 % at a Ce:Te:Mo molar ratio of 1:0.2:1. The prepared 99 Mo/ 99m Tc chromatographic column based on Ce(IV) tellurium molybdate gel bed showed a good performance. The 99m Tc elution yield was 77.8±3.0 % with a radionuclidic purity of ≥ 99.99 %, radiochemical purity of 96.5±1.3 % (as 99m TcO 4-) and pH-value in the range of 5-7. Molybdenum and cerium levels in 99m Tc eluates did not exceed 1 and 0.3 ppm, respectively, while no tellurium was detected.

show abstract

Influence of drying conditions of zirconium molybdate gel on performance of 99mTc gel generator

Cited by 21 publications

References 14 publications

Preparation of 99Mo from the 100Mo(γ, n) reaction and chemical separation of 99mTc

Preparation of 99Mo from the 100Mo(γ, n) reaction and chemical separation of 99mTc

Preparation and performance of ⁹⁹Mo/^99mTc chromatographic column generator based on zirconium molybdosilicate

Preparation and characterization of cerium(IV) tellurium molybdate gel and its application as a bed for chromatographic <sup>99</sup>Mo/<sup>99m</sup>Tc generator

Contact Info

Product

Resources

About

Influence of drying conditions of zirconium molybdate gel on performance of 99mTc gel generator

Cited by 21 publications

References 14 publications

Preparation of 99Mo from the 100Mo(γ, n) reaction and chemical separation of 99mTc

Preparation of 99Mo from the 100Mo(γ, n) reaction and chemical separation of 99mTc

Preparation and performance of 99Mo/99mTc chromatographic column generator based on zirconium molybdosilicate

Preparation and characterization of cerium(IV) tellurium molybdate gel and its application as a bed for chromatographic <sup>99</sup>Mo/<sup>99m</sup>Tc generator

Contact Info

Product

Resources

About

Preparation and performance of ⁹⁹Mo/^99mTc chromatographic column generator based on zirconium molybdosilicate