Influence of dydrogesterone on the activity of the nonpregnant human uterus

RETRACTED: Oral dydrogesterone treatment during early pregnancy to prevent recurrent pregnancy loss and its role in modulation of cytokine production: a double-blind, randomized, parallel, placebo-controlled trial

“…Treatment with dydrogesterone before the stress reduced the number of miscarriages, restored PIBF levels, and decreased uterine levels of Th1 cytokines (24). Progestogens also reduce the synthesis of prostaglandins directly, thereby relaxing uterine smooth musculature and preventing inappropriate uterine contractions that may result in miscarriage (25,26).…”

Assessment of changes in endometrial and subendometrial volume and vascularity during the normal menstrual cycle using three‐dimensional power Doppler ultrasound

“…However, the results of studies examining uterine/endometrial contractility during the normal menstrual cycle are conflicting. Only one of four studies10–13 (that of Eskes et al 10) reported a change in uterine contractility around the time of ovulation with high‐frequency low‐intensity contractions and high basal pressure. Whether uterine contractility has anything to do with the changes in endometrial vascularization that we observed remains uncertain.…”

Uterine contractility and embryo implantation

“…The limitation of IUP recording lies in its invasive nature that restricts the number and duration of recordings [14,15,[18][19][20][21][22][23][24][25][26].…”

“…All authors have reported an increase in uterine contraction frequency at or near the time of ovulation [20,45,[47][48][49]. Estradiol being the primary utero-stimulant, it is an increase in estradiol levels occurring in the late follicular phase that has been seen as the triggering factor for the pre-ovulatory increase in uterine contractility.…”