Influence of Early Postoperative Feeding in Gastrointestinal Anastomotic Fistula Formation and Healing Time in Rabbits

Abstract

Objectives To determine whether early postoperative feeding attenuates the inhibitory effects of intestinal anastomosis in rabbits. Methods After undergoing gastrointestinal anastomosis, 48 rabbits were randomly divided into experimental and control groups. The rabbits in the experimental group were fed a liquid diet beginning 24 h postoperatively, while the control rabbits received only total parenteral nutrition after the operation. Exploratory laparotomies were performed on four rabbits in each group 3, 5, 7, 10, and 15 days postoperatively, and the healing rate of the anastomosis, anastomotic bursting pressure, anastomotic breaking strength, and hydroxyproline content at the anastomosis were determined. Results The anastomoses healed in 91.6% (22/24) of the control group and 95.8% (23/24) of the experimental group. The anastomotic bursting pressure decreased remarkably in both groups 3 days postoperatively, reaching the lowest value. The anastomotic breaking strength did not differ between the two groups 3 days postoperatively, when both reached their lowest points, and both groups increased markedly and peaked 10 days postoperatively. The hydroxyproline content of the anastomosis was slightly lower in the experimental group 3 days postoperatively, although both groups peaked 7 days postoperatively. Conclusions Early postoperative feeding does not increase the anastomosis healing time or rate of gastrointestinal anastomosis leakage.

Early versus late oral feeding following total (pharyngo)laryngectomy: Systematic review and meta‐analysis

“…9 Based on observations of how mucosal tissue heals within the first 48 h and the success of Enhanced Recovery After Surgery protocols in gastrointestinal surgery involving bowel anastomosis, it is reasonable to hypothesize that early oral feeding may also be a feasible option following laryngectomy. 10,11 Indeed, a number of studies over the last two decades have reported comparable outcomes between early and late oral feeding regimes. [12][13][14][15][16][17] A previous systematic review examining the relationship between PCF and time of oral feeding in eight studies (four randomized controlled trials (RCTs) and four cohort studies) concluded that there were no differences in PCF rates between those fed before the fifth day and those fed after the seventh day.…”

“…Based on observations of how mucosal tissue heals within the first 48 h and the success of Enhanced Recovery After Surgery protocols in gastrointestinal surgery involving bowel anastomosis, it is reasonable to hypothesize that early oral feeding may also be a feasible option following laryngectomy 10,11 . Indeed, a number of studies over the last two decades have reported comparable outcomes between early and late oral feeding regimes 12‐17 …”

Early oral feeding after gastrointestinal anastomosis

“…The presence of flatus and BM are used to represent the end of POI and the ability of the postsurgical GI patient to tolerate oral food [8,10,20,24] . The postoperative LOS used as one of the evaluation indices of EOF [21] . In our study, early oral intake is associated with a shorter postoperative LOS and bowel function recovery quicker in the EOF group.…”

Innovative approach: utilizing silver nanoparticles sheet for improved rabbit cecal anastomosis healing

“…The 3 cm before and after the cecum anastomotic line was fixed to a tensile test machine (an AG-X Plus Desktop 10 kN, Pneumatic Grip, Shimadzu, Japan) at a rate of 60 mm/min until rupture occurred. The weight necessary to break the anastomotic tissue was recorded as the tissue tensile strength ( 33 ).…”