SRAM based on SOI devices has been widely used in aerospace storage devices due to its good electrical characteristics and radiation resistance. However, with the development of semiconductor technology, the feature size of devices continues to shrink, and the irradiation effects of high-energy ions have become increasingly serious. Single event effect has become the biggest threat to the failure of the spacecraft. A mixed-simulation method was used to research the heavy ion irradiation effects on SOI SRAM. SRAM consists of two coupled inverters. Firstly, the voltage changes of the inverter and SRAM output nodes under heavy ion irradiation were compared and analyzed, then the influence of the device itself and heavy ion parameters on the single particle flipping effect of the SRAM is investigated, and finally the necessary conditions for the flipping of the stored information in the SRAM are discussed and derived. The results show that heavy ion incidence does not permanently change the final state of the inverter; devices in the off state in the SRAM will undergo information flipping only when they are irradiated by heavy ions, and the threshold voltage of the N-type MOSFET is lower than that of the P-type MOSFET; an increase in the penetration depth will accelerate the flipping speed of the SRAM, but when the LET is high, the influence of the penetration depth on the flipping speed decreases; the change of the stored information in the SRAM is the result of the combined effect of pulse width and pulse height.