Influence of electromagnetic field (1800 MHz) on lipid peroxidation in brain, blood, liver and kidney in rats

Bodera, Paweł; Stankiewicz, Wanda; Antkowiak, Bożena; Paluch, Małgorzata; Kieliszek, J.; Sobiech, J.; Niemcewicz, Marcin

doi:10.13075/ijomeh.1896.00255

Cited by 20 publications

(11 citation statements)

References 19 publications

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“…Also, the results of previous studies on the effects of EHF EMI on lipid peroxidation are still contradictory (Sharov et al, 1983;Logani, Ziskin, 1996;Bodera et al, 2015). Due to this issue, the present study was aimed to investigate the effects of 42.2 and 50.3 GHz MMW frequencies on the lipid peroxidation in different organs of whole body exposure rats.…”

Section: Introductionmentioning

confidence: 90%

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Effect of whole body extremely high frequency electromagnetic irradiation exposure on lipid peroxidation in rats

Poghosyan¹,

Mikaelyan²,

Nerkararyan³

et al. 2017

biologija

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Background. Electromagnetic irradiation with extremely high frequencies (EHF EMI) and low intensity affects living organisms of a different level of organization, but the mechanism(s) of its influence is still not understood well. This study was undertaken to examine the effects of EHF EMI on tissue lipid peroxidation (LPO) of whole body exposure rats.Material and methods. Male Wistar rats were selected for this study. The animals were divided into two groups: sham exposed and experimental. The rats were exposed to the EMI of 42.2 and 50.3 GHz frequencies (power density 0.06 mW/cm 2 ) for 20 min/ day, for five days. The content of malondialdehyde (MDA) as the final product of the LPO was estimated in brain, liver, heart, and skeletal muscle of rats.Results. Treatment with EMI induced oxidative stress in different organs of the rats, which was indicated by the changes of MDA level depending on the EMI frequency used and exposure duration. The MDA rate shows significant increase in brain (P < 0.001) depending on the treatment duration for both EMI frequencies used. The slightly elevated levels of MDA in the liver were observed among rats in 50.3 GHz frequency EMI-exposed group. Concerning the skeletal muscle and especially the cardiac tissue, the MDA values remained at the same levels in experimental and control groups and did not differ significantly.Conclusions. The EHF EMI applied in the multiple mode significantly enhanced the lipid peroxidation level in the brain and slightly increased the same parameter in liver. The obtained data indicate possible health implications of such exposures, which may cause damage in brain.

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Section: Introductionmentioning

confidence: 90%

“…There are numerous animal studies that have shown various examples of how microwave (SHF EMI) induce ROS and changes in antioxidant enzymes activity in blood, brain, kidneys and other organs (Kesari et al, 2011;Kesari et al, 2012;Bodera et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Effect of whole body extremely high frequency electromagnetic irradiation exposure on lipid peroxidation in rats

Poghosyan¹,

Mikaelyan²,

Nerkararyan³

et al. 2017

biologija

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“…As, Türedi et al, [16] who observed that continuous exposure to 900-MHz of EMR for 1 h / day on postnatal G3b G4a days 22-59, caused an increase in oxidative stress and various pathological changes in bladders and kidneys of male rats. Also, Bodera et al, [17] revealed that exposure to 1800 MHz of EMR caused elevation of MDA levels in blood, brain, and kidney of the experimental rats. Furthermore, other studies detected marked increases in the inflammatory oxidative stress markers after exposure to EMR at 2450MHz exposures on different organs and tissues like heart [18], laryngeotracheal mucosal tissues [19], liver and kidney [20] by increasing MDA, total oxidant status, GSH-PX levels and decreasing TAS levels.…”

Section: (Figure3)mentioning

confidence: 97%

EFFECT OF EXPOSURE TO ELECTROMAGNETIC RADIATION ON SEX STEROIDS AND SYSTEMIC & LOCAL UTERINE REDOX STATUS DURING EARLY AND LATE PREGNANCY IN RATS

Mahmoud

Diab

Mahmoud

et al. 2019

Zagazig University Medical Journal

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Background: pregnant women are at high risk of exposure to environmental EMR because of their higher oxygen consumption and amniotic fluid-induced ROS, which is associated with adverse pregnancy outcomes. The present study was designed to demonstrate the effects of EMR exposure at 900, 1800, and 2450 MHz on the female sex hormones (estrogen, progesterone) and systemic and local uterine redox status during early and late stages of pregnancy in adult albino rats. Methods: The present study was carried out on 88 weaned albino female rats were divided into four equal groups: control group: rats were not exposed to EMR, group2: rats were exposed to 900 MHz EMR, group3: rats were exposed to 1800 MHz EMR (emitted from mobile phones), and group 4: rats were exposed to 2450 MHz EMR (emitted from Wi-Fi). After induction of pregnancy each group was subdivided into two equal groups: early pregnant and late pregnant subgroups. At the end of each experimental period samples were collected for estimation of serum estradiol & progesterone and plasma and local oxidative stress markers. Results: The present study showed that EMR exerted a significant frequency and duration dependent reduction in serum estrogen, progesterone, plasma TAS, vitamin C and uterine GSH which was accompanied by significant increase in plasma and uterine MDA. Conclusions: Exposure to EMR induced progressive reduction in sex steroid hormones, and imbalance in oxidative/antioxidative stress parameters in pregnant rats. These effects were dependent on the frequency and the duration of the EMR.

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“…Penelitian paparan gelombang elektromagnetik menggunakan frekuensi sebesar 1800 MHz selama 15 menit dalam 5 hari berturutturutdapat meningkatan kadar malondialdehid (MDA) pada darah, otak dan ginjal tikus wistar. 6 Paparan radiasi radio frekuensi terhadap eritosit manusia menunjukan terjadinya peningkatan lipid peroksidase setelah 1 dan 2 jam pemaparan. 7 Paparan medan magnet 50 Hz selama 15 menit dengan densitas 1,5 dan 12 mT menunjukan terjadinya penurunan pada kadar kolesterol dan trigliserida dalam plasma.…”

Section: Pendahuluanunclassified

PENGARUH LAMA PAPARAN RADIASI MEDAN ELEKTROMAGNETIK HANDPHONE TERHADAP KADAR MALONDIALDEHID DAN KADAR KOLESTEROL PADA TIKUS (Rattus norvegicus) STRAIN WISTAR ALBINO

Fitri¹,

Almasi‐Hashiani²,

Asri³

2018

JKA

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AbstrakPaparan radiasi gelombang elektromagnetik handphonedapat menimbulkan gangguan pada organ tubuh dengan meningkatkan kadar malondialdehid dan menurunkan kadar kolesterol. Penelitian ini bertujuan untuk membuktikan paparan gelombang elektromagnetik handphonedapat meningkatkan kadar malondialdehid dan menurunkan kadar kolesterol pada tikus (Rattus novergicus) jantan galur wistar albino. Penelitian ini merupakan eksperimental dengan desain penelitian Post Test Only Control Groupyang menggunakan 24 ekor tikus (Rattus novergicus) jantan, galur wistar albino, berumur 2-3 bulan, yang terbagi menjadi 4 (empat) kelompok masing-masing berjumlah 6 ekor tikus. Kelompok kontrol (K) tidak diberikan paparan radiasi handphone. Kelompok perlakuan (P1) diberi paparan radiasihandphone 30 menit/hari, kelompok perlakuan 2 (P2) dengan paparan radiasi 60 handphonemenit/hari dan kelompok perlakuan 3 (P3) dengan paparan radiasi handphone 90 menit/hari selam 51 hari. Setelah dilakukan perlakuan selama 51 hari,darah diambil dari retro orbitalis dan kadar malondialdehid diperiksa dengan metode Thiobarbituric Reactive substances (TBARs) dan kadar kolesterol di ukur dengan metode Cholesterol Oxidase-Peroksidase Aminoantipyrine Phenol (CHOD-PAP). Hasil penelitian menunjukkan bahwa rerata kadar malondialdehid kelompok K ialah 2,376 nmol/ml, kelompok P1 2,890 nmol/ml, kelompok P2 3,306 nmol/ml, kelompok P3 3,800 nmol/ml. Rerata kadar kolesterol kelompok kontrol (K) 77,816 mg/dl, kelompok perlakuan 1 (P1) 71,350 mg/dl, kelompok perlakuan 2 (P2) 71,173 mg/dl dan kelompok perlakuan 3 (P3) 70,916 mg/dl.Pada analisa data didapatkan kadar malondialdehid dan kadar kolesterol tikus p < 0,05 berarti ada perbedan bermakna antar kelompok kontrol dengan kelompok perlakuan. Kesimpulan penelitian ini ada pengaruh lama paparan radiasi handphone terhadap kadar malondiladehid dan kadar kolesterol tikus jantan Rattus novergicus galur Wistar Albino. Kata kunci: Radiasi elektromagnetik handphone, Malondialdehid, kolesterol AbstractExposure to mobile phone electromagnetic radiation can cause interference with organs by increasing malondialdehyde levels and lowering cholesterol levels. This study aims to prove the exposure of electromagnetic waves mobile phones can increase levels of malondialdehid and reduce cholesterol levels in rats (Rattus novergicus) males wistar albino strain. The research type was experimental with Post Test Only Control Group research design using 24 male rats (Rattus novergicus), wistar albino strain, 2-3 months old, divided into 4 (four) groups of 6 rats each. The control group (K) was not given exposure to cell phone radiation. The treatment group (P1) was exposed to mobile phone radiation 30 minutes / day, treatment group 2 (P2) with radiation exposure 60 minutes / day and treatment group 3 (P3) with cell phone radiation exposure 90 minutes / hr for 51 days. After 51 days of treatment, blood was taken from the retro orbitalis and the malondialdehid levels were examined by the method of Thiobarbituric Reactive substances (TBARs) and c...

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Influence of electromagnetic field (1800 MHz) on lipid peroxidation in brain, blood, liver and kidney in rats

Abstract: The electromagnetic field exposure (EMF), applied in the repeated manner together with opioid drug tramadol (TRAM), slightly enhanced lipid peroxidation level in brain, blood, and kidneys.

Cited by 20 publications

References 19 publications

Effect of whole body extremely high frequency electromagnetic irradiation exposure on lipid peroxidation in rats

Effect of whole body extremely high frequency electromagnetic irradiation exposure on lipid peroxidation in rats

EFFECT OF EXPOSURE TO ELECTROMAGNETIC RADIATION ON SEX STEROIDS AND SYSTEMIC & LOCAL UTERINE REDOX STATUS DURING EARLY AND LATE PREGNANCY IN RATS

PENGARUH LAMA PAPARAN RADIASI MEDAN ELEKTROMAGNETIK HANDPHONE TERHADAP KADAR MALONDIALDEHID DAN KADAR KOLESTEROL PADA TIKUS (Rattus norvegicus) STRAIN WISTAR ALBINO

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