Influence of environmental factors in the<i>in vitro</i>dehydration of hydrogel and silicone hydrogel contact lenses

Martín-Montañéz, Vicente; López-Miguel, Alberto; Arroyo, Cristina Arroyo-del; Mateo, María Eugenia Rodríguez; González-Meijóme, José Manuel; Calonge, Margarita; González-García, María J.

doi:10.1002/jbm.b.33057

Cited by 21 publications

(16 citation statements)

References 17 publications

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“…Under this highly constricted condition, and taking into account that the water confined does not interact, or interact quite weakly with the surface, water diffusion is slower in hydrophobic channels than in bulk water, at least when lens is exposed to low HR% environments. This might be relevant in the behaviour of hydrogel and silicone hydrogel contact lenses as they are subjected to dehydration at the ocular surface, and particularly when the environmental conditions change …”

Section: Discussionmentioning

confidence: 99%

“…A recent work published by Martín–Montañez et al showed that among diverse conventional hydrogel and silicone hydrogel lenses, Comfilcon A was the lens with faster evaporation rates after exposure to extreme environmental conditions of low RH and high temperature. However, a comparison between Si‐Hy lenses demonstrates that water flux and transmissibility values decrease when the EWC decreases.…”

Section: Discussionmentioning

confidence: 99%

“…This might be relevant in the behaviour of hydrogel and silicone hydrogel contact lenses as they are subjected to dehydration at the ocular surface, [48][49][50][51] and particularly when the environmental conditions change. 52,53 A recent work published by Mart ın-Montañez et al 52 showed that among diverse conventional hydrogel and silicone hydrogel lenses, Comfilcon A was the lens with faster evaporation rates after exposure to extreme environmental conditions of low RH and high temperature. However, a comparison between Si-Hy lenses demonstrates that water flux and transmissibility values decrease when the EWC decreases.…”

Section: P5mentioning

confidence: 99%

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Oxygen, water, and sodium chloride transport in soft contact lenses materials

Gavara

Compañ

2016

J Biomed Mater Res

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Oxygen permeability, diffusion coefficient of the sodium ions and water flux and permeability in different conventional hydrogel (Hy) and silicone-hydrogel (Si-Hy) contact lenses have been measured experimentally. The results showed that oxygen permeability and transmissibility requirements of the lens have been addressed through the use of siloxane containing hydrogels. In general, oxygen and sodium chloride permeability values increased with the water content of the lens but there was a percolation phenomenon from a given value of water uptake mainly in the Si-Hy lenses which appeared to be related with the differences between free water and bound water contents. The increase of ion permeability with water content did not follow a unique trend indicating a possible dependence of the chemical structure of the polymer and character ionic and non-ionic of the lens. Indeed, the salt permeability values for silicone hydrogel contact lenses were one order of magnitude below those of conventional hydrogel contact lenses, which can be explained by a diffusion of sodium ions occurring only through the hydrophilic channels. The increase of the ionic permeability in Si-Hy materials may be due to the confinement of ions in nanoscale water channels involving possible decreased degrees of freedom for diffusion of both water and ions. In general, ionic lenses presented values of ionic permeability and diffusivity higher than most non-ionic lenses. The tortuosity of the ionic lenses is lower than the non-ionic Si-Hy lenses. Frequency 55 and PureVision exhibited the highest water permeability and flux values and, these parameters were greater for ionic Si-Hy lenses than for ionic conventional hydrogel lenses. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2218-2231, 2017.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: P5mentioning

confidence: 99%

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Oxygen, water, and sodium chloride transport in soft contact lenses materials

Gavara

Compañ

2016

J Biomed Mater Res

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“…It is well known that conventional hydrogels have always incorporated higher water content in order to achieve higher oxygen permeability. However, high water content contact lenses tended to dehydrate to a higher degree, thereby causing certain physiological disorders . Therefore, in order to avoid physiological complications, manufacturers designed thicker contact lenses, which led to a reduction of oxygen transmission and an increase in potential mechanical complications.…”

mentioning

confidence: 99%

Impact of contact lens material and design on the ocular surface

Ruiz-Alcocer

Monsálvez-Romín

García‐Lázaro

et al. 2018

Clinical and Experimental Optometry

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“…The silicon‐based polymer polydimethylsiloxane (PDMS) has received significant attention because of its several appealing properties such as good optical transparency, high gas permeability, nontoxicity, biocompatibility, and heat resistance. Due to these advantages, PDMS‐based elastomers have been widely used as biocompatible devices (eg, contact lenses), micro fluidic devices, and drug delivery carriers . However, the hydrophobic nature of the surface confines its wide use in some applications, particularly for biocompatible devices, because some hydrophobic molecules, proteins, and cells are easily absorbed to the surface.…”

Section: Inroductionmentioning

confidence: 99%

Reverse hydrophobic PDMS surface to hydrophilic by 1‐step hydrolysis reaction

Zhang

Kalulu

Wang

et al. 2018

Polymers for Advanced Techs

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Hydrophilic modification on the surface of polymer polydimethylsiloxane (PDMS) material is a key step for its application in biomaterial, bioengineering, and so on. In this article, a novel and effective method was proposed to reverse hydrophobic surface to hydrophilic by 1‐step hydrolysis of Si―O bond to produce hydrophilic hydroxyl group. The hydrophilizing reagent 2‐(trimethylsiloxy) ethyl methacrylate (TMSEMA) was used during the copolymerization of polydimethylsiloxane prepolymer (DMS U21). The prepared PDMS film was subjected to 1‐step surface hydrophilic reversal treatment using KOH solution to produce hydroxyl groups on the surface. The contact angle, attenuated total reflection Fourier transform infrared spectra, and equilibrium water content (EWC) measurements were conducted on PDMS films. The results showed that TMSEMA content had no obvious impact on the contact angle and EWC value of untreated PDMS. After reversal treatment, the contact angle decreased from 94° to 15°, and the EWC value increases to 10% when the TMSEMA content was 15 wt%. The spectrum proved that the reverse reaction produced hydroxyl and carboxylate on the surface. The hydrophilic stability, surface morphology, and protein adsorption properties of PDMS film were also investigated. This study can provide new ideas and further reference for improving the hydrophilicity of PDMS surface.

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Influence of environmental factors in thein vitrodehydration of hydrogel and silicone hydrogel contact lenses

Abstract: Lower RH seems to increase CL dehydration being further accelerated with the AF presence. The dehydration pattern is material dependent, thus current marketed CLs behave differently under several controlled environmental conditions. Future in vivo studies should confirm these outcomes.

Cited by 21 publications

References 17 publications

Oxygen, water, and sodium chloride transport in soft contact lenses materials

Oxygen, water, and sodium chloride transport in soft contact lenses materials

Impact of contact lens material and design on the ocular surface

Reverse hydrophobic PDMS surface to hydrophilic by 1‐step hydrolysis reaction

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