We studied the relationship of the thermoregulation reactions activation degree with microclimatic
conditions at workplaces, the functional state of female workers and their reproductive health. The labor
of women workers in the polymer processing industry is accompanied by the combined effect of factors
complex of the working environment and the labor process. Leading ones are the heating microclimate
and physical activity. Hygienic assessment of the working conditions of the studied occupational groups
(women professions of pressers, casters, extruders, high-frequency installations serving workers, rollers,
calenders) showed that the resulting classes of working conditions correspond to hazard classes 3.2-3.3,
which can determine the risk of reproductive disorders. The heating microclimate in combination with
physical activity causes the thermoregulation system stress, which is manifested in an increase of skin
temperature, sweating. According to the results of the in-depth gynecological examination, an increase
of 1.3-2 times the frequency of gynecological morbidity was revealed. The main forms of gynecological
pathology among female workers in the polymer processing industry were: prolapse of the uterus and
vaginal walls, benign tumors, menstrual disorders and inflammatory diseases of the female pelvic
organs. The state of women reproductive system is considered as an integral assessment of the impact of
working conditions. A comparative analysis of objective hygienic data of working conditions and their
subjective assessments by female workers made it possible to identify with the help of multiple regression
analysis the relationship between risk factors and reproductive health, which allows us to improve and
substantiate preventive measures in the workplace. We presented a mathematical model that allows to
evaluate and predict the dependence of reproductive health disorders on the studied factors of working
conditions, and also use it to develop practical recommendations.