Influence of epigenetics on periodontitis and peri‐implantitis pathogenesis

Larsson, Lena; Kavanagh, Nolan M.; Nguyen, Trang Van; Castilho, Rogerio M.; Berglundh, Tord; Giannobile, William V.

doi:10.1111/prd.12453

Cited by 39 publications

(27 citation statements)

References 127 publications

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“…The immune response to bacterial challenges is not only influenced by genetic factors but also by environmental factors 10 . Epigenetics involves the study of gene function independent of changes to the DNA sequence and its associated proteins, and represents a critical link between genetic and environmental factors.…”

Section: Introductionmentioning

confidence: 99%

“…The immune response to bacterial challenges is not only influenced by genetic factors but also by environmental factors. 10 Epigenetics involves the study of gene function independent of changes to the DNA sequence and its associated proteins, and represents a critical link between genetic and environmental factors. Epigenetic modifications have been shown to contribute to the progression of several diseases, including chronic inflammatory diseases like periodontitis and peri‐implantitis.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors for periodontitis & peri‐implantitis

Darby

2022

Periodontology 2000

102

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Risk is part of all health professions and generally indicates the chance of getting some form of illness. For dental practitioners this includes periodontitis or peri‐implantitis, the focus of this issue. Many risk factors are involved in the development of disease and most likely interact or overlap. Most patients will probably have multiple risk factors, some of which will be the same for both periodontitis and peri‐implantitis. The most recent classification of periodontal disease recognises the importance of risk factors and contemporary dental practice requires that clinicians be aware of and manage them. Broadly speaking risk factors can be patient, environment or practitioner related. Patient risk factors would include socio‐economic status, smoking, substance use disorders, diabetes, diet and dietary supplements, mental health disorders, old age, poor home dental care or understanding of the need for good home care and use of medications. Environmental modification of the host response through gene function is an emerging risk factor. Lastly, practitioner‐related factors in implant dentistry are now known to affect risk. These would include the use of digital technology, but patient related factors such implant location and the body’s reaction to an implant itself add to the risk of developing disease. This edition of Periodontology provides an uptodate review of many of these risk factors and their impact summarising current knowledge.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Risk factors for periodontitis & peri‐implantitis

Darby

2022

Periodontology 2000

102

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“…It does not modify the DNA sequence, but can regulate how genes are expressed, including DNA methylation, histone modification, chromatin remodeling, non-coding RNA editing and other gene regulation methods. The dysregulation of any link will affect the abnormality of chromatin structure and gene expression, which will lead to the occurrence of diseases ( 24 , 25 ). In recent years, studies have found that epigenetic modification plays an important role in the occurrence and development of cardiovascular diseases, and many epigenetic changes are reversible, which provides an optimistic prospect for disease treatment ( 26 , 27 ).…”

Section: Epigenetic Modification and Endothelial-mesenchymal Transitionmentioning

confidence: 99%

Histone modification of endothelial-mesenchymal transition in cardiovascular diseases

Qiu

Zhong³

et al. 2022

Front. Cardiovasc. Med.

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Endothelial-mesenchymal transition (EndMT) is a differentiation process in which endothelial cells lose their own characteristics and acquire mesenchymal-like characteristics, which contributes to the formation and development of atherosclerotic plaques. Until now, there is still a lack of effective measures to treat atherosclerosis (AS), so there is an urgent need to understand the underlying mechanisms of AS. In addition, although various studies have shown that EndMT is involved in the pathological stages of cardiovascular diseases, such as myocardial fibrosis, myocardial hypertrophy, and hypertension, the specific molecular mechanisms driving EndMT are still in the exploratory stage. In this review, we review the role of histone modifications (methylation, demethylation and acetylation, deacetylation) on EndMT in cardiovascular disease, aiming to target histone-modifying enzymes to guide cardiovascular disease therapy.

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“…Periodontitis is a multifactorial disease which is born from an alteration of the balance between host, environment, and immune system [ 1 ]. The progression of the lesion is certainly mediated by the attack of bacteria that colonise the tooth surface, the gingival margin, and the subgingival environment in a susceptible host [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy Ozone Therapy in Reducing Periodontal Disease

2023

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The aim of this study is to highlight the properties of ozone as an aid to non-surgical therapy compared to non-surgical therapy alone. This study included thirty Caucasian patients (eighteen women and twelve men) aged between 35 and 65, recruited at the Oral Hygiene and Prevention Center of the Dental Clinic of the Vita-Salute San Raffaele University, at the San Raffaele hospital in Milan. The periodontal probing was recorded with a PC-PUNC 15 manual probe (Hu Friedy) at time 0; the scaling and root planing session was performed at T1 with or without the aid of ozone therapy, and then, the patients were re-evaluated at one month (T2), three months (T3), and six months (T4). The results obtained show that there are not statistically significant differences in terms of reduction in clinical periodontal indices such as plaque, bleeding, and pocket depth between the two groups. Therefore, treatment with ozoral gel would not seem to improve non-surgical periodontal therapy alone. However, clinical periodontal indices significantly improved in patients treated with non-surgical therapy and ozone gel. From this point of view, ozone gel can be used as an aid to non-surgical therapy due to its excellent characteristics, in particular, its powerful virucidal action.

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Influence of epigenetics on periodontitis and peri‐implantitis pathogenesis

Cited by 39 publications

References 127 publications

Risk factors for periodontitis & peri‐implantitis

Risk factors for periodontitis & peri‐implantitis

Histone modification of endothelial-mesenchymal transition in cardiovascular diseases

Efficacy Ozone Therapy in Reducing Periodontal Disease

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