Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model

Sánchez-Fidalgo, Susana; Ibargüen, L. Sánchez de; Cárdeno, Ana; Lastra, Catalina Alarcón de la

doi:10.1007/s00394-011-0235-y

Cited by 117 publications

(114 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast, in a DSS-induced chronic colitis in mice, Sánchez-Fidalgo et al[13] reported that a diet containing 10% of EVOO enriched with a polyphenol extract reduced histopathological colitis scores and inflammatory markers. They also demonstrated that dietary EVOO and EVOO enriched with hydroxytyrosol reduced the severity of chronic colonic damage induced by an acute exposure to DSS [12]. Similarly, Takashima et al[30] reported that a 5% olive oil-rich diet attenuated inflammation in DSS-induced colitis in rats.…”

Section: Discussionmentioning

confidence: 98%

“…Although multiple sources of evidence support the anti-inflammatory effect of olive oil and its phenolic compounds [3], their beneficial effects in inflammatory bowel disease (IBD) have been almost exclusively studied in animal models of chemically induced colitis and involved the reduction of COX-2 and iNOS expression [12, 13]. However, such animal models do not accurately reflect the human disease pathogenesis [14].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary Extra-Virgin Olive Oil Polyphenols Do Not Attenuate Colon Inflammation in Transgenic HLAB-27 Rats but Exert Hypocholesterolemic Effects through the Modulation of HMGCR and PPAR-α Gene Expression in the Liver

Bigagli¹,

Toti²,

Lodovici³

et al. 2018

Lifestyle Genomics

View full text Add to dashboard Cite

Background: Human studies have demonstrated that olive oil phenolic compounds reduce inflammatory markers associated with chronic diseases. Objectives: To explore the anti-inflammatory effects of extra-virgin olive oil polyphenols in an experimental model of inflammatory bowel disease (IBD). Methods: HLA-B27 transgenic rats were fed an AIN-76 diet containing 10% corn oil (CO) or extra-virgin olive oil with high (EVOO) or low phenolic content (ROO) for 3 months. Wild-type rats (WT) were fed the CO diet. Results: CO-fed HLA-B27 animals developed intestinal inflammation characterized by diarrhea, increased myeloperoxidase activity, and mucosal injury. None of these parameters were influenced by EVOO. Gene expression profiling indicated that proinflammatory pathways were upregulated in the colon mucosa of CO-fed HLA-B27 rats compared to WT, and this was further confirmed by RT-PCR for the iNOS, TNFα, and IL1β genes. EVOO significantly reduced TNFα gene expression in the colon mucosa and decreased total cholesterol blood levels compared to CO HLA-B27 rats (89.43 ± 3.66 vs. 111.5 ± 8.10 mg/dL, p < 0.05). This latter effect with EVOO was associated with reduced HMGCR and increased PPAR-α hepatic gene expression, compared to ROO. Conclusion: These data indicate that olive oil polyphenols do not control colon inflammation in HLA-B27 transgenic rats but exert a positive effect on blood lipids by reducing total cholesterol levels. This preliminary result suggests the need to explore the efficacy of EVOO rich in polyphenols as a complementary strategy for managing hypercholesterolemia and to potentially limit statin-associated myotoxicity.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Dietary Extra-Virgin Olive Oil Polyphenols Do Not Attenuate Colon Inflammation in Transgenic HLAB-27 Rats but Exert Hypocholesterolemic Effects through the Modulation of HMGCR and PPAR-α Gene Expression in the Liver

Bigagli¹,

Toti²,

Lodovici³

et al. 2018

Lifestyle Genomics

View full text Add to dashboard Cite

show abstract

“…This preparation, called HT-20, significantly inhibited the acute inflammation and lowered tissue IL-1 and TNF levels. More recently, Sánchez-Fidalgo et al [131] reported that HTyr -enriched extra-VOO attenuated chronic dextran sulfate sodium (DSS)-induced colitis in mice and decreased COX-2, iNOS via downregulation of p38MAPK. Accordingly, Giner et al [125] found that oleuropein ameliorates acute DSS-colitis in mice while reducing TNF , IL-1 and IL-6 production, iNOS, COX-2 and MMP-9 expression, and NF-kB activation in colon tissue.…”

Section: In Vivo Htyr-mediated Anti-inflammatory Activity and Cancermentioning

confidence: 99%

Naturally Occurring Hydroxytyrosol: Synthesis and Anticancer Potential

Bernini¹,

Merendino²,

Romani³

et al. 2013

CMC

View full text Add to dashboard Cite

Several epidemiological and animal studies have suggested that polyphenols, a group of secondary plant metabolites occurring mainly in the plant kingdom, may have a protective effect against some chronic degenerative diseases such as cancer. Polyphenols are part of the human diet, being present in vegetal food and beverages. Among them, an olive biophenol named hydroxytyrosol [2-(3,4-dihydroxyphenyl)ethanol, HTyr] has recently received particular attention because of its antioxidant, antiproliferative, pro-apoptotic, and anti-inflammatory activities, which have the potential to specifically counteract all cancer hallmarks, thus representing the expectant biological activities underlying the anti-tumor properties of this polyphenol. After a description of the synthetic procedures to prepare pure HTyr, this review takes into consideration the chemopreventive and chemotherapeutic potential of HTyr as the result of its antioxidant, antiproliferative and anti-inflammatory activities. In particular, the review is focused on the current knowledge of the main cellular and molecular mechanisms used by HTyr to affect carcinogenesis, highlighting the specific oncogenic and inflammatory signaling pathways potentially targeted by HTyr.

show abstract

“…The level of MPO activity is directly related to the neutrophil concentration in the inflamed tissue Therefore, measuring MPO activity is considered as a quantitative and sensitive assay for acute intestinal inflammation (44). Many studies showed that herbs and their main components such as phenols and polyphenols decreased MPO level and improved inflammation in the colonic tissue of ulcerative colitis animals (45)(46)(47). In this study, a significant reduction was detected in neutrophil infiltration in colonic mucus and MPO activity of animal subjects with colitis treated with M. officinal.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Effect of Melillotus officinalis L. Aqueous Extracts on Healing of Acetic Acid-Induced Ulcerative Colitis in Male Rats

Tanideh¹,

Bahrani²,

Khoshnood-Mansoorkhani³

et al. 2016

Ann Colorectal Res

View full text Add to dashboard Cite

show abstract

Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model

Cited by 117 publications

References 40 publications

Dietary Extra-Virgin Olive Oil Polyphenols Do Not Attenuate Colon Inflammation in Transgenic HLAB-27 Rats but Exert Hypocholesterolemic Effects through the Modulation of HMGCR and PPAR-α Gene Expression in the Liver

Dietary Extra-Virgin Olive Oil Polyphenols Do Not Attenuate Colon Inflammation in Transgenic HLAB-27 Rats but Exert Hypocholesterolemic Effects through the Modulation of HMGCR and PPAR-α Gene Expression in the Liver

Naturally Occurring Hydroxytyrosol: Synthesis and Anticancer Potential

Evaluating the Effect of Melillotus officinalis L. Aqueous Extracts on Healing of Acetic Acid-Induced Ulcerative Colitis in Male Rats

Contact Info

Product

Resources

About