Influence of Extracellular Vesicles of the Follicular Fluid on Morphofunctional Characteristics of Human Sperm

Sysoeva, A. P.; Makarova, N. P.; Silachev, Denis N.; Lobanova, N. N.; Shevtsova, Yu. A.; Брагина, Е. Е.; Kalinina, Kalinina E.A.; Сухих, Г. Т.

doi:10.1007/s10517-021-05372-4

Cited by 3 publications

(1 citation statement)

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“…When spermatozoa penetrate the cumulus, they fuse, and this step is aided by the ovum’s secretion of EVs. Furthermore, after follicular fluid enters the fallopian tube following ovulation, FF-EVs may promote sperm motility and fertilization ( Sysoeva et al, 2021 ). Surprisingly, oocytes and cumulus cells can take up SP-EVs, and rabbit SP-EVs can promote cumulus expansion and affect mRNA expression of cumulus cells and oocytes, including PTGS2 and NTRK, which are involved in oocyte development and maturation ( Abumaghaid et al, 2022 ).…”

Section: The Role Of Evs In Gametes Fertilizationmentioning

confidence: 99%

Messenger roles of extracellular vesicles during fertilization of gametes, development and implantation: Recent advances

Fan

Wang

et al. 2023

Front. Cell Dev. Biol.

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Extracellular vesicles (EVs) have become a research hotspot in recent years because they act as messengers between cells in the physiological and pathological processes of the human body. It can be produced by the follicle, prostate, embryo, uterus, and oviduct in the reproductive field and exists in the extracellular environment as follicular fluid, semen, uterine cavity fluid, and oviduct fluid. Because extracellular vesicles are more stable at transmitting information, it allows all cells involved in the physiological processes of embryo formation, development, and implantation to communicate with one another. Extracellular vesicles carried miRNAs and proteins as mail, and when the messenger delivers the mail to the recipient cell, the recipient cell undergoes a series of changes. Current research begins with intercepting and decoding the information carried by extracellular vesicles. This information may help us gain a better understanding of the secrets of reproduction, as well as assist reproductive technology as an emerging marker and treatment.

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Section: The Role Of Evs In Gametes Fertilizationmentioning

confidence: 99%