Influence of fasting and protein deprivation on food self-selection in the rat☆

Piquard, François; Schaefer, Adrien; Haberey, P

doi:10.1016/0031-9384(78)90304-9

Cited by 59 publications

(18 citation statements)

References 31 publications

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“…An energy deficit, produced by fasting, was compensated by an increase in fat intake; fasted rats eat more fat in order to take in as much energy as possible in a small volume of food. This increased fat intake was also observed by other investigators (4,5,14) who used different sources of fat. These facts, therefore , suggest that increased fat intake could be related to changes in metabolic status during and after fasting.…”

supporting

confidence: 72%

“…Fat may be involved in the long-term regulation of food intake (22). Various investigators have noted a relation between body weight and fat intake, and in particular, that an increased intake is related to a decrease in body weight (4,5,23). Da Costa and Clayton (24) observed that in rats undernourished for 90 days , the recovery of lost body weight was possible only with a high-fat diet.…”

mentioning

confidence: 99%

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Relation of body energetic status to dietary self-selection in Sprague-Dawley rats.

Matsuo

Shimakawa

Ikeda

et al. 1984

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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supporting

confidence: 72%

mentioning

confidence: 99%

Relation of body energetic status to dietary self-selection in Sprague-Dawley rats.

Matsuo

Shimakawa

Ikeda

et al. 1984

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…However, since our rats were neither starving nor ketotic (unpublished data). Furthermore, our results differed from those produced by brief caloric restriction (such as overnight food deprivation), which has been reported to increase intake of carbohydrate and fat (4,7,24).…”

Section: Discussioncontrasting

confidence: 84%

Protein appetite is increased after central leptin-induced fat depletion

Wiater

Hudson²,

Virgin³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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Leptin reduces body fat selectively, sparing body protein. Accordingly, during chronic leptin administration, food intake is suppressed, and body weight is reduced until body fat is depleted. Body weight then stabilizes at this fat-depleted nadir, while food intake returns to normal caloric levels, presumably in defense of energy and nutritional homeostasis. This model of leptin treatment offers the opportunity to examine controls of food intake that are independent of leptin's actions, and provides a window for examining the nature of feeding controls in a "fatless" animal. Here we evaluate macronutrient selection during this fat-depleted phase of leptin treatment. Adult, male Sprague-Dawley rats were maintained on standard pelleted rodent chow and given daily lateral ventricular injections of leptin or vehicle solution until body weight reached the nadir point and food intake returned to normal levels. Injections were then continued for 8 days, during which rats self-selected their daily diet from separate sources of carbohydrate, protein, and fat. Macronutrient choice differed profoundly in leptin and control rats. Leptin rats exhibited a dramatic increase in protein intake, whereas controls exhibited a strong carbohydrate preference. Fat intake did not differ between groups at any time during the 8-day test. Despite these dramatic differences in macronutrient selection, total daily caloric intake did not differ between groups except on day 2. Thus controls of food intake related to ongoing metabolic and nutritional requirements may supersede the negative feedback signals related to body fat stores.

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“…To the degree that fat preference is determined by orosensory factors, and that the fat-free cake simulates the sensory characteristics of the high-fat version, the two cakes should be equally preferred. Cake preference was measured under both nondeprived and food deprived conditions because prior work indicates that deprivation may enhance fat preference (3,14,26). The second part of the study compared the long-term effects of the fat-free and high-fat cakes on caloric intake and body weight gain.…”

Section: Introductionmentioning

confidence: 99%

Feeding Response of Rats to No‐Fat and High‐Fat Cakes

et al. 1993

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The nutritional effects of high-fat diets have been extensively studied in laboratory animals, but as yet few experiments have examined the feeding response of animals to newly developed fat substitutes. The present study used commercially available no-fat (0% fat, 92% carbohydrate) and high-fat (41% fat, 54% carbohydrate) cake to determine the effects of fat substitutes on food preference and caloric intake in rats. The first experiment showed that nondeprived rats found the high-fat and no-fat cakes equally palatable and highly preferred to lab chow. Food deprived rats, however, preferred the high-fat cake to the no-fat cake, which may be related to its higher caloric density. In the second experiment, rats fed high-fat cake, in addition to chow, for 30 days consumed more calories and gained more weight than did rats fed no-fat cake and chow. The no-fat cake group, however, overate a n d gained more weight than chow-only controls. The hyperphagic response to the no-fat cake can be attributed to its carbohydrate content, moisture, and high palatability. Thus, removing fat from the cake reduced, but did not eliminate, its obesity-promoting effect. Obviously, low-fat foods must be consumed in moderation if used for weight control. (OBESITY RESEARCH 1993;1:173-178)

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Influence of fasting and protein deprivation on food self-selection in the rat☆

Cited by 59 publications

References 31 publications

Relation of body energetic status to dietary self-selection in Sprague-Dawley rats.

Relation of body energetic status to dietary self-selection in Sprague-Dawley rats.

Protein appetite is increased after central leptin-induced fat depletion

Feeding Response of Rats to No‐Fat and High‐Fat Cakes

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