Influence of flavonoids isolated from Satureja hortensis L. on hypercholesterolemic rabbits

Mchedlishvili, D.; Kuchukashvili, Zurab; Tabatadze, T; Davitaia, G

doi:10.4103/0253-7613.16577

Cited by 7 publications

(2 citation statements)

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“…The study of Momtaz and Abdollahi (2010) indicates that some Satureja species, including SKE, can be utilized as an enhancement in hyperlipidemic diabetic patients due to their lipid-lowering and antioxidant characteristics ( Vosough-Ghanbari et al, 2010 ). The flavonoids extracted from summer savory reduce cholesterol in rabbits and lead to a considerable decrease in serum cholesterol ( Mchedlishvili et al, 2005 ). Rats ingesting S. khuzestanica essential oils showed a considerable increase in total antioxidant capacity and a reduction in normal blood lipid peroxidation levels S. khuzestanica oil’s antioxidant properties may explain its triglyceride-lowering properties ( Abdollahi et al, 2003 ).…”

Section: An Overview Of the Biological Activities Of Summer Savory Ex...mentioning

confidence: 99%

A comprehensive review of summer savory (Satureja hortensis L.): promising ingredient for production of functional foods

Ejaz¹,

Waliat²,

Arshad³

et al. 2023

Front. Pharmacol.

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This review aims to measure the different aspects of summer savory including biological activity, medicinal properties, nutritional value, food application, prospective health benefits, and its use as an additive in broiler feed. Furthermore, toxicity related to this is also overviewed. Summer savory leaves are abundant in total phenolic compounds (rosmarinic acid and flavonoids) that have a powerful antioxidant impact. Rosmarinic (α-O-caffeoyl-3,4-dihydroxy-phenyl lactic) acid has been identified in summer savory as a main component. According to phytochemical investigations, tannins, volatile oils, sterols, acids, gums, pyrocatechol, phenolic compounds, mucilage, and pyrocatechol are the primary compounds of Satureja species. Summer savory extract shows considerable biological potential in antioxidant, cytotoxic, and antibacterial assays. Regarding antioxidant activity, summer savory extract displays an inhibitory effect on lipid peroxidation. Summer savory also has Fe (III) reductive and free radical scavenging properties and contains minerals and vitamins. Summer savory has important biological properties, including antimicrobial activity and antioxidant activity, and protective effects against Jurkat T Cells, Alzheimer’s disease, cancer, infection, cardiovascular diseases, diabetes, and cholesterol. The leaves and stems of this plant are employed in the food, feed, and pharmacological industries due to their antioxidant properties and substantial nutritional content. Conclusively, summer savory is widely considered beneficial for human health due to its versatile properties and medicinal use.

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Section: An Overview Of the Biological Activities Of Summer Savory Ex...mentioning

confidence: 99%

A comprehensive review of summer savory (Satureja hortensis L.): promising ingredient for production of functional foods

Ejaz¹,

Waliat²,

Arshad³

et al. 2023

Front. Pharmacol.

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“…Phenolic compounds exert multiple biological effects such as antioxidant, free radical scavenging and anti-inflammatory properties [ 15 ]. Due to accumulated compounds, S. hortensis L. possess antioxidant, antibacterial, antispasmodic, antidiarrheic, hypoglycemic, and anti-hypercholesterolemic effects [ 16 , 17 , 18 , 19 , 20 , 21 ]. However, environmental factors strongly influence the biosynthesis of polyphenols known as secondary metabolites of medicinal and aromatic plants, which means that the exact therapeutic activity of S. hortensis L. depends on the place of origin [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Chemical Composition, Radical Scavenging and Antitumor Activities of Satureja hortensis L. Herb Extracts

Bimbiraitė-Survilienė

Stankevičius

Šuštauskaitė

et al. 2021

Antioxidants

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Satureja hortensis L. is an annual herbaceous plant of the Lamiaceae Lindl. family. S. hortensis L., related to thyme and rosemary, is used as spice and traditional medicinal herb in Europe. Mainly due to the polyphenols contained in S. hortensis L., this plant exhibits multiple biological effects. However, therapeutic effects on cells, including skin tumors, have not yet been studied. Therefore, the aim of this study was to compare the composition and the resulting antioxidant as well as biological properties [on melanocytes and melanoma cells] of summer, savory growing in botanical garden of Vytautas Magnus University in middle Lithuania climatic conditions, collected during various phases of vegetation. It has been shown that the budding phase alcohol extract of this plant contains the largest amounts of polyphenols, including rutin and rosemary acid, which promote the radical scavenging activity and antioxidant properties. In contrast, the extract from the massive flowering phase already at a concentration of 12.5 µg/mL reduces the survival of melanoma cells to 60% with 90% melanocytes survival. In addition, extracts from beginning of flowering and end of flowering at a concentration of 25 µg/mL, containing significantly less rutin and rosmarinic acid, in combination with irradiation of cells with UVB, significantly increased the lipid peroxidation process, particularly in melanoma cells. These data indicate the possibility of using extracts from S. hortensis L. to modulate/differentiate the metabolism of normal and tumor skin cells.

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A Critical Overview on the Pharmacological and Clinical Aspects of Popular Satureja Species

Jafari

Ghavidel

Zarshenas

2016

Journal of Acupuncture and Meridian Studies

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Throughout the world, various parts of most Satureja species are traditionally used to treat patients with various diseases and complications. As for the presence of different classes of metabolites in Satureja and their numerous ethnomedical and ethnopharmacological applications, many species have been pharmacologically evaluated. The current work aimed to compile information from pharmacological studies on this savory for further investigations. The keyword Satureja was searched through Scopus and PubMed up to January 1, 2016. We found nearly 55 papers that dealt with the pharmacology of Satureja. We found that 13 species had been evaluated pharmacologically and that Satureja khuzestanica, Satureja bachtiarica, Satureja montana and Satureja hortensis appeared to be the most active, both clinically and phytopharmacologically. Regarding the content of rich essential oil, most evaluations were concerned with the antimicrobial properties. However, the antioxidant, antidiabetic and anticholesterolemic properties of the studied species were found to be good. In addition to the pharmacological activities that have been indentified for some species, opportunities still exist to assess the effectiveness of other well-known species. If different Satureja species are to have extensive ethnopharmacological applications, comprehensive assessments of the acute and chronic toxicities, as well as the teratogenicity, of those plants are needed.

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Influence of flavonoids isolated from Satureja hortensis L. on hypercholesterolemic rabbits

Cited by 7 publications

References 1 publication

A comprehensive review of summer savory (Satureja hortensis L.): promising ingredient for production of functional foods

A comprehensive review of summer savory (Satureja hortensis L.): promising ingredient for production of functional foods

Evaluation of Chemical Composition, Radical Scavenging and Antitumor Activities of Satureja hortensis L. Herb Extracts

A Critical Overview on the Pharmacological and Clinical Aspects of Popular Satureja Species

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