Influence of glyceryl behenate, tripalmitin and stearic acid on the properties of clarithromycin incorporated solid lipid nanoparticles (SLNs): Formulation, characterization, antibacterial activity and cytotoxicity

Öztürk, A. Alper; Aygül, Abdurrahman; Şenel, Behiye

doi:10.1016/j.jddst.2019.101240

Cited by 46 publications

(32 citation statements)

References 27 publications

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“…Solid lipid-nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) represent the two main nanoparticles sub-types made up of lipids. SLNs are drug delivery systems in colloid form composed of high melting-stable lipids that were developed to beat the instability problems of liposomes [90]. Techniques for fabrication of SLNs include; solvent emulsification-diffusion, supercritical fluid, microemulsion-based, and film-ultrasound dispersion method [91].…”

Section: Lipid-based Nanoparticlesmentioning

confidence: 99%

Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

et al. 2020

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Based on the recent reports of World Health Organization, increased antibiotic resistance prevalence among bacteria represents the greatest challenge to human health. In addition, the poor solubility, stability, and side effects that lead to inefficiency of the current antibacterial therapy prompted the researchers to explore new innovative strategies to overcome such resilient microbes. Hence, novel antibiotic delivery systems are in high demand. Nanotechnology has attracted considerable interest due to their favored physicochemical properties, drug targeting efficiency, enhanced uptake, and biodistribution. The present review focuses on the recent applications of organic (liposomes, lipid-based nanoparticles, polymeric micelles, and polymeric nanoparticles), and inorganic (silver, silica, magnetic, zinc oxide (ZnO), cobalt, selenium, and cadmium) nanosystems in the domain of antibacterial delivery. We provide a concise description of the characteristics of each system that render it suitable as an antibacterial delivery agent. We also highlight the recent promising innovations used to overcome antibacterial resistance, including the use of lipid polymer nanoparticles, nonlamellar liquid crystalline nanoparticles, anti-microbial oligonucleotides, smart responsive materials, cationic peptides, and natural compounds. We further discuss the applications of antimicrobial photodynamic therapy, combination drug therapy, nano antibiotic strategy, and phage therapy, and their impact on evading antibacterial resistance. Finally, we report on the formulations that made their way towards clinical application.

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Section: Lipid-based Nanoparticlesmentioning

confidence: 99%

Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

et al. 2020

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“…When the results are examined in general and the spray-dried NP studies intended for oral administration are examined, the results seem appropriate for the intended purposes [3,6,19]. PDI value which defines PS distribution is in the range of 0.01 and 0.7 for monophasic systems; value higher than 0.7 is indicative of a very wide PS distribution and the value close to zero means narrow PS distribution [20]. When the PDI results are discussed in this literature information, it can be said that blank and CEF loaded NP formulations are monodisperse.…”

Section: Particle Size Polydispersity Index and Zeta Potentialmentioning

confidence: 99%

“…For this purpose the dialysis bag method was chosen to investigate CEF release from the NP formulation in PBS (pH 6.8). In the literature review, it was frequently encountered that the release properties of oral systems were evaluated in PBS (pH 6.8) [20,26,27,28]. In vitro release profile of pure CEF powder and NP formulations are shown in Figure 3.…”

Section: In Vitro Release and Release Kinetic Evaluationmentioning

confidence: 99%

“…Fitting in vitro release profiles to mathematical models which describes drug release as a function of time gives valuable data about the in vivo release behavior of optimal delivery system [30]. After obtaining the release profiles, data were transferred to the DDSolver program to determine the four most important and popular criteria: coefficient of determination (Rsqr, R 2 , or COD), adjusted coefficient of determination (Rsqr_adj or R 2 adjusted), Akaike Information Criterion (AIC), Model Selection Criterion (MSC) [20]. It has been shown in many studies that these criteria are used to select the correct release kinetics [20,31].…”

Section: In Vitro Release and Release Kinetic Evaluationmentioning

confidence: 99%

“…After obtaining the release profiles, data were transferred to the DDSolver program to determine the four most important and popular criteria: coefficient of determination (Rsqr, R 2 , or COD), adjusted coefficient of determination (Rsqr_adj or R 2 adjusted), Akaike Information Criterion (AIC), Model Selection Criterion (MSC) [20]. It has been shown in many studies that these criteria are used to select the correct release kinetics [20,31]. In most studies, R 2 has been reported to be the most important criterion for model selection [32,33,34,35].…”

Section: In Vitro Release and Release Kinetic Evaluationmentioning

confidence: 99%

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Design of cefaclor monohydrate containing nanoparticles with extended antibacterial effect by Nano-Spray dryer: A Nanoenglobing study

Öztürk¹,

Aygül²

2020

jrp

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Spray drying is an important method used in pharmaceutical product manufacturing for many years. The nano-spray dryer developed in recent years provides ultrafine powders at nanoscale and high product yields. In this study, which was aimed at prolonged release in oral use, nanoparticles-(NPs) were obtained by nanoenglobation of cefaclor monohydrate-(CEF) with Eudragit RS 100-(ERS) with the help of nano-spray drying method. The particle size (PS) of the blank formulation was 186 nm whereas PSs of CEF containing NPs were between 328 and 389 nm. The average PDI of all NP formulations were below 0.4 and all prepared NPs had a positive ZP value. The encapsulation efficiency values were a range of 78-84 %. In vitro release studies of NPs showed extended-release up to 24 hours after the first 3 hours of burst effect. The results showed that the release kinetics were fitted to the Korsmeyer-Peppas model. As a result, it was found that all pharmaceutical technology analysis results were affected by the solid concentration ratio in the feed dispersion. Antibacterial activity of NP formulations was determined by microdilution method. After minimum inhibitory concentration (MIC) determination, time-dependent activity for NP-2 was investigated by the time-kill method. MIC value for NP-2 was 4-fold lower than MIC value of CEF for Staphylococcus aureus and Escherichia coli. No growth was observed for both bacteria with NP-2 during 18 hours incubation in the time-kill method. As a result, prolonged antibiotic release and long-term antibacterial activity were obtained by NP-2, the optimum formulation of our study.

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Kinetic Modeling to Explain the Release of Medicine from Drug Delivery Systems

Askarizadeh,

Esfandiari,

Honarvar

et al. 2023

ChemBioEng Reviews

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Proper medication dissolution must be ensured when developing or manufacturing a new solid dosage form. Quantitative analyses performed in dissolution or release tests become simpler when applying mathematical formulae which represent dissolution outcomes as a function of several dosage form properties. Methodologies utilized to examine the kinetics of drug release from controlled‐release formulations are reviewed. The analysis of variance was conducted using statistical, model‐independent, and ‐dependent techniques for the dissolution profile comparison and fitting, respectively. Model equations, including zero‐ and first‐order, Hixson‐Crowell, Weibull, Higuchi, Korsmeyer‐Peppas, Baker‐Lonsdale, Hopfenberg, etc., were employed to match the experimental data. Additional release parameters were taken to illustrate the drug release patterns. Using correlation factors and the Akaike information criterion (AIC), the best‐fitting model was discovered, as were the transport phenomena affecting the behavior of the recognized formulations.

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Influence of glyceryl behenate, tripalmitin and stearic acid on the properties of clarithromycin incorporated solid lipid nanoparticles (SLNs): Formulation, characterization, antibacterial activity and cytotoxicity

Cited by 46 publications

References 27 publications

Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

Design of cefaclor monohydrate containing nanoparticles with extended antibacterial effect by Nano-Spray dryer: A Nanoenglobing study

Kinetic Modeling to Explain the Release of Medicine from Drug Delivery Systems

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