Influence of gonadal hormones on protein-lipid relationships in human plasma

Hormones, Cholesterol, and Coronary Atherosclerosis

“…The rise in serum cholesterol is greater than that of phospholipid, and the cholesterol:phospholipid ratio is increased. 8 An increase of lowdensity (beta) lipoproteins, both in spontaneous and in induced myxedema, is largely in the Sf 0-12 moiety but is found also in fractions Sf 12- 49 As nloted above, the phospholipid changes are muore marked thain the cholesterol changes. As with most agents, the cholesterol fall is greatest in those instances in which initial values are highest.…”

Effect of Hormonal Environment on Sterol Concentrations of Rat Aorta and Plasma

“…Sex differences in aorta and plasma sterols were observed in the oil-controls which represented normal titers for each sex and which could be contrasted with all treatment groups. Differences between sterols in males and females have been reported for several species (9, 21), including humans (18), and higher sterol titers in males have been cited as evidence for a greater incidence of atherosclerosis due to androgen action. Find ings of higher cholesterol levels in the aorta and lower plasma cholesterol in male rats are consistent with previously reported results (9,14,15) indicating preatherosclerotic conditions in the male, possibly due to a higher rate of choles terol filtration from plasma into the aorta.…”

Effect of Prolonged Use of Estrogens on Circulating Lipids in Patients with Idiopathic Hyperlipemia or Idiopathic Hypercholesteremia

“…', [10][11][12][13][14][15][16] Patients with idiopathic hyperlipemia or idiopathic hypercholesteremia provide a unique material for the study of disturbances in circulating lipids per se and in relation to lipid deposition in the tissues that often accompanies these disorders. 17 …”