Influence of group III/IV muscle afferents on small muscle mass exercise performance: a bioenergetics perspective

Broxterman, Ryan M.; Hureau, Thomas J.; Layec, Gwenael; Morgan, David; Bledsoe, Amber D.; Jessop, Jacob E.; Amann, Markus; Richardson, Russell S.

doi:10.1113/jp275817

Cited by 41 publications

(58 citation statements)

References 70 publications

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“…; Broxterman et al . ). Whether the reduced contractile economy with ageing is a result of inefficiencies in neural activation of the muscle, chemomechanical coupling of the myosin‐actin interaction (myofibrillar ATPase) and/or ion transport (Ca 2+ and/or Na + ‐K + ATPases) is unknown and worth further investigation.…”

Section: Discussionmentioning

confidence: 97%

“…However, surprisingly, we did not observe a greater age-related depletion in the [ATP] during the exercise suggesting that the old adults may have relied to a greater extent on the adenylate kinase reaction to maintain a stable [ATP]. Although the explanation remains unclear, the disproportionate increase in [P i ] relative to the decrease in [PCr] was also observed when the ATP cost of contraction was increased in young men by attenuating group III//IV afferent feedback via lumbar intrathecal fentanyl administration (Broxterman et al 2017;Broxterman et al 2018). Whether the reduced contractile economy with ageing is a result of inefficiencies in neural activation of the muscle, chemomechanical coupling of the myosin-actin interaction (myofibrillar ATPase) and/or ion transport (Ca 2+ and/or Na + -K + ATPases) is unknown and worth further investigation.…”

Section: Age-related Increases In Fatigability Are Explained By An Inmentioning

confidence: 99%

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Bioenergetic basis for the increased fatigability with ageing

Sundberg

Prost

Fitts

et al. 2019

The Journal of Physiology

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Key points The mechanisms for the age‐related increase in fatigability during dynamic exercise remain elusive. We tested whether age‐related impairments in muscle oxidative capacity would result in a greater accumulation of fatigue causing metabolites, inorganic phosphate (Pi), hydrogen (H+) and diprotonated phosphate (H2PO4−), in the muscle of old compared to young adults during a dynamic knee extension exercise. The age‐related increase in fatigability (reduction in mechanical power) of the knee extensors was closely associated with a greater accumulation of metabolites within the working muscle but could not be explained by age‐related differences in muscle oxidative capacity. These data suggest that the increased fatigability in old adults during dynamic exercise is primarily determined by age‐related impairments in skeletal muscle bioenergetics that result in a greater accumulation of metabolites. Abstract The present study aimed to determine whether the increased fatigability in old adults during dynamic exercise is associated with age‐related differences in skeletal muscle bioenergetics. Phosphorus nuclear magnetic resonance spectroscopy was used to quantify concentrations of high‐energy phosphates and pH in the knee extensors of seven young (22.7 ± 1.2 years; six women) and eight old adults (76.4 ± 6.0 years; seven women). Muscle oxidative capacity was measured from the phosphocreatine (PCr) recovery kinetics following a 24 s maximal voluntary isometric contraction. The fatiguing exercise consisted of 120 maximal velocity contractions (one contraction per 2 s) against a load equivalent to 20% of the maximal voluntary isometric contraction. The PCr recovery kinetics did not differ between young and old adults (0.023 ± 0.007 s−1 vs. 0.019 ± 0.004 s−1, respectively). Fatigability (reductions in mechanical power) of the knee extensors was ∼1.8‐fold greater with age and was accompanied by a greater decrease in pH (young = 6.73 ± 0.09, old = 6.61 ± 0.04) and increases in concentrations of inorganic phosphate, [Pi], (young = 22.7 ± 4.8 mm, old = 32.3 ± 3.6 mm) and diprotonated phosphate, [H2PO4−], (young = 11.7 ± 3.6 mm, old = 18.6 ± 2.1 mm) at the end of the exercise in old compared to young adults. The age‐related increase in power loss during the fatiguing exercise was strongly associated with intracellular pH (r = –0.837), [Pi] (r = 0.917) and [H2PO4−] (r = 0.930) at the end of the exercise. These data suggest that the age‐related increase in fatigability during dynamic exercise has a bioenergetic basis and is explained by an increased accumulation of metabolites within the muscle.

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Section: Discussionmentioning

confidence: 97%

Section: Age-related Increases In Fatigability Are Explained By An Inmentioning

confidence: 99%

Bioenergetic basis for the increased fatigability with ageing

Sundberg

Prost

Fitts

et al. 2019

The Journal of Physiology

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“…Moreover, both muscle activation, as estimated by electromyographic activity, and time under tension have been shown to be directly related to the perceived exertion response [19,22]. It appears that metabolite accumulation can affect afferent feedback in the central nervous system and thus decrease performance and contractile efficiency [24]. Moreover, this may in turn influence RPE.…”

Section: Introductionmentioning

confidence: 99%

Comparison of blood lactate and perceived exertion responses in two matched time-under-tension protocols

Vargas-Molina

Martín-Rivera

Bonilla³

et al. 2020

PLoS ONE

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The aim of this study was to compare the concentration of blood lactate [bLa-] and the subjective perception of exertion of trained men in a moderate repetition protocol (MRP) versus a high repetition protocol (HRP) equated for time under tension. Methods A sample of 40 healthy young men (aged, 23.2 ± 4.0 years; height, 177.3 ± 7.0 cm; BMI, 24.3 ± 2.2) performed two sessions of 8 sets of bicep curls with a one-week recovery interval between the trials. In the HRP protocol, 20 repetitions were performed with a cadence of 2 seconds of eccentric and 1 second of concentric, while in the MRP protocol 10 repetitions were performed with 4 seconds of eccentric and 2 seconds of concentric. Cadences were controlled by a metronome. At the beginning and end of each of the sessions, blood lactate was taken at 2, 15, and 30 minutes, and rating of perceived exertion (OMNI-RES) was assessed immediately after completion of each session. Results There were [bLa-] differences between protocols in the MRP 2 min, (5.2 ±1.4); 15 min, (3.2 ±1.2); 30 min, (1.9 ±0.6); p< 0.05, and the HRP 2 min, (6.1 ±1.6); 15 min, (3.7 ±1.1); 30 min, (2.2 ±0.6); p<0.01. OMNI-RES was higher in HRP, (8.8 ±0.7) than in MRP, (7.7 ±0.9). Additionally, a correlation was found between the RPE and [bLa-] values in the HRP protocol (rs = 0.35, p < 0.01).

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“…within the severe‐intensity domain) (Dekerle et al., ; Ferguson et al., ). Several lines of evidence indicate that CP/CT is aerobic in nature (Broxterman et al., ) and seems to represent a ‘critical threshold’ above which task failure is coincident with complete utilization of

W^{'}, {\overset{V}{true}}_{{normalO}_{2} \max}

attainment and similar muscle fatigue (i.e. decreased maximal voluntary force) (Burnley, Vanhatalo, & Jones, ; Jones, Wilkerson, DiMenna, Fulford, & Poole, ; Jones et al., ; Poole, Ward, Gardner, & Whipp, ).…”

Section: Introductionmentioning

confidence: 99%

“…reduced maximal voluntary contraction) and peripheral fatigue and the magnitude of W ′ during handgrip exercise performed with blood flow occlusion. More recently, studies have demonstrated that group III/IV muscle afferents constrain the intramuscular perturbations and muscle contraction efficiency during small muscle mass exercises performed using both submaximal (Broxtermann et al., ) and maximal (Broxterman et al., ) muscle contractions.…”

Section: Introductionmentioning

confidence: 99%

Effects of resistance training on impulse above end‐test torque and muscle fatigue

Bassan

Denadai

Lima

et al. 2019

Experimental Physiology

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New Findings What is the central question of this study?What role do neuromuscular fatigue mechanisms play in resistance training‐induced adaptations of the impulse above end‐test torque (IET) after the training period? What is the main finding and its importance?IET and global and peripheral fatigue were increased after a short period of resistance training. Thus, resistance training‐induced adaptations in neuromuscular fatigue seem to contribute to enhanced IET after the training period. Abstract Short‐term resistance training has a positive influence on the curvature constant of the power–duration relationship (W′). The physiological mechanism of W′ enhancement after resistance training is unclear. This study aimed to determine whether one‐leg maximal isometric resistance training influences (1) impulse above end‐test torque (IET; an analogue of W′) during a 5 min all‐out isometric test; and (2) exercise tolerance (limit of tolerance, Tlim) and neuromuscular fatigue during severe exercise (i.e. above end‐test torque; ET). Sixteen healthy active males participated in a 3‐week unilateral knee extensor resistance‐training programme, and 10 matched subjects participated as controls. The subjects were instructed to ramp up to 100% of maximal voluntary contraction (MVC) over 1 s, hold it for 3 s, and relax. Each repetition had a 2 s interval (10) and each set, a 2 min interval (3). MVC (18.6%) and muscle thickness (12.8%) were significantly improved after training. Significantly greater global (i.e. reduced MVC, 43.2 ± 13.5% vs. 58.9 ± 6.9%) and peripheral (51.7 ± 13.6% vs. 57.3 ± 15.3%) fatigue, IET (26%) and Tlim (92%) were obtained after resistance training. Moreover, both global (r = 0.57, P < 0.05) and peripheral fatigue (r = 0.55, P < 0.05) accrued during severe exercise were associated with IET. However, echo intensity, which reflects muscle quality, ET and central fatigue remained unchanged throughout the training period. No significant changes in the control group for any variable were observed. Resistance training‐induced adaptations in muscle size and neuromuscular fatigue seem to contribute to enhanced IET and Tlim after the training period.

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Influence of group III/IV muscle afferents on small muscle mass exercise performance: a bioenergetics perspective

Cited by 41 publications

References 70 publications

Bioenergetic basis for the increased fatigability with ageing

Bioenergetic basis for the increased fatigability with ageing

Comparison of blood lactate and perceived exertion responses in two matched time-under-tension protocols

Effects of resistance training on impulse above end‐test torque and muscle fatigue

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