Influence of guided waves in bone on pulse‐inversion contrast‐enhanced ultrasound

Wang, Diya; Zhang, Xinyu; Sang, Yuchao; Qu, Zhen; Su, Qiang; Zhao, Jing; Wan, Mingxi

doi:10.1002/mp.13634

Cited by 4 publications

(3 citation statements)

References 40 publications

(120 reference statements)

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“…Variations in m values and gradients with the increase in NLCRs induced by an increase in pulse length and a decrease in frequency were more obvious than corresponding alterations induced by an increase in acoustic pressure. Herein, the frequency coincided with the EMB resonant frequency when it was decreased; in consequence, the second harmonic NLCRs were obviously enhanced and had the largest ranges of increase. The increase in NLCRs controlled by the frequency resulted in quasi‐linear increases of m values in both simulations and experimental validations.…”

Section: Discussionmentioning

confidence: 77%

Numerical and experimental investigation of impacts of nonlinear scattering encapsulated microbubbles on Nakagami distribution

et al. 2019

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Purpose The Nakagami statistical model and Nakagami shape parameter m have been widely used in linear tissue characterization and preliminarily characterized the envelope distributions of nonlinear encapsulated microbubbles (EMBs). However, the Nakagami distribution of nonlinear scattering EMBs lacked a systematical investigation. Thus, this study aimed to investigate the Nakagami distribution of EMBs and illustrate the impact of EMBs' nonlinearity on the Nakagami model. Method A group of simulated EMB phantoms and in vitro EMB dilutions with an increasing concentration distribution under various EMB nonlinearities, as regulated by acoustic parameters, were characterized by using the window‐modulated compounding Greenwood–Durand estimator. Results Raw envelope histograms of simulated and in vitro EMBs were well matched with the Nakagami distribution with a high correlation coefficient of 0.965 ± 0.021 (P < 0.005). The mean values and gradients of m parameters of simulated and in vitro EMBs were smaller than those of linear scatterers due to the stronger nonlinearity. These m values exhibited a quasi‐linear improvement with the increase in second harmonic nonlinear‐to‐linear component ratio regulated by pulse lengths and excitation frequencies at low‐ and high‐concentration conditions. Conclusions The Nakagami distribution was suitable for the EMBs characterization but the corresponding m parameter was affected by the EMBs' nonlinearity. These validations provided support and nonlinear impact assessment for the EMBs' characterization using the Nakagami statistical model in the future.

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Section: Discussionmentioning

confidence: 77%

Numerical and experimental investigation of impacts of nonlinear scattering encapsulated microbubbles on Nakagami distribution

et al. 2019

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“…Pulse inversion (PI) and amplitude modulation (AM) are the most commonly used schemes. PI consecutively emits two pulse sequences with the same frequency and amplitude but 180° phase reversal to increase MBs signals as well as counteract tissue signals by coherent summation [ 52 ]. AM realizes the same purpose using a series of pulses with different amplitudes [ 53 ].…”

Section: Mbs Used For Efficient Intravascular Contrastmentioning

confidence: 99%

Ultrasound contrast agents from microbubbles to biogenic gas vesicles

2022

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Microbubbles have been the earliest and most widely used ultrasound contrast agents by virtue of their unique features: such as non-toxicity, intravenous injectability, ability to cross the pulmonary capillary bed, and significant enhancement of echo signals for the duration of the examination, resulting in essential preclinical and clinical applications. The use of microbubbles functionalized with targeting ligands to bind to specific targets in the bloodstream has further enabled ultrasound molecular imaging. Nevertheless, it is very challenging to utilize targeted microbubbles for molecular imaging of extravascular targets due to their size. A series of acoustic nanomaterials have been developed for breaking free from this constraint. Especially, biogenic gas vesicles, gas-filled protein nanostructures from microorganisms, were engineered as the first biomolecular ultrasound contrast agents, opening the door for more direct visualization of cellular and molecular function by ultrasound imaging. The ordered protein shell structure and unique gas filling mechanism of biogenic gas vesicles endow them with excellent stability and attractive acoustic responses. What’s more, their genetic encodability enables them to act as acoustic reporter genes. This article reviews the upgrading progresses of ultrasound contrast agents from microbubbles to biogenic gas vesicles, and the opportunities and challenges for the commercial and clinical translation of the nascent field of biomolecular ultrasound.

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“…The effects of RF and VF processing on the axial and lateral resolutions of mand m log -coded MEUS were quantified using the −2 dB half-lengths of autocorrelation functions 10,[33][34][35] of data along six lines (center location of the kidney, center location AE8 mm) in axial and lateral directions that transect the image. The axial and lateral lines were divided into 10 segments with an overlap rate of 50%, and the axial and lateral half-widths were calculated as the average values of −2 dB half-lengths of the autocorrelation functions.…”

Section: E Data Analysismentioning

confidence: 99%

In vivo Nakagami‐m parametric imaging of microbubble‐enhanced ultrasound regulated by RF and VF processing techniques

et al. 2020

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Purpose Application of the Nakagami statistical model and associated m parameter has the potential to suppress artifacts from adjustable system parameters and operator selections typical in echo amplitude‐coded microbubble‐enhanced ultrasound (MEUS). However, the feasibility of applying m estimation and determination of the associated Nakagami distribution features for in vivo MEUS remain to be investigated. Sensitivity and discriminability of m‐coded MEUS are often limited since raw envelopes are regulated by complex radiofrequency (RF) and video‐frequency (VF) processing. This study aims to develop an improved imaging approach for the m parameter estimation which can overcome the above limitations in in vivo condition. Method The regulation effects of RF processing of pulse‐inversion (PI) harmonic detection techniques and VF processing of logarithmic compression in Nakagami distributions were investigated in MEUS. A window‐modulated compounding moment estimator was developed to estimate the MEUS m values. The sensitivity and discriminability of m‐coded MEUS were quantified with contrast‐to‐tissue ratio (CTR), contrast‐to‐noise ratio (CNR), and axial and lateral resolutions, which were validated through in vivo perfusion experiments on rabbit kidneys. Results Regulated by RF and VF processing, the distributions of MEUS obeyed the Nakagami statistical model. The Nakagami‐fitted correlation coefficient was 0.996 ± 0.003 (P < 0.05 in the t test and P < 0.001 in the Kolmogorov−Smirnov test). Among each of the m‐coded MEUS methods, the logarithmic m‐coded PI‐MEUS scheme effectively characterized the peripheral rim perfusion features and details within the renal cortex. The CTR and CNR in this region reached 7.9 ± 1.5 dB and 34.4 ± 1.7 dB, respectively, which were higher than those of standard amplitude‐coded MEUS; and the axial and lateral resolutions were 1.02 ± 0.02 and 0.91 ± 0.02 mm, respectively, which were slightly longer than those of amplitude‐coded MEUS. Conclusions The Nakagami statistical model could characterize MEUS even when the envelope distributions were regulated by RF and VF processing. The logarithmic m‐coded PI‐MEUS scheme significantly improved the sensitivity, discriminability, and robustness of m estimation in MEUS. The scheme provides an option to remove artifacts in echo amplitude‐coded MEUS and to distinctly characterize the inherent microvasculature enhanced by microbubbles, with potential to improve and expand the role of MEUS in diagnostic ultrasound.

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Influence of guided waves in bone on pulse‐inversion contrast‐enhanced ultrasound

Cited by 4 publications

References 40 publications

Numerical and experimental investigation of impacts of nonlinear scattering encapsulated microbubbles on Nakagami distribution

Numerical and experimental investigation of impacts of nonlinear scattering encapsulated microbubbles on Nakagami distribution

Ultrasound contrast agents from microbubbles to biogenic gas vesicles

In vivo Nakagami‐m parametric imaging of microbubble‐enhanced ultrasound regulated by RF and VF processing techniques

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