Influence of Heat-Treated Bovine Bone-Derived Hydroxyapatite on Physical Properties andin vitroDegradation Behavior of Poly (Lactic Acid) Composites

Abstract

In this work, nano-size HA was produced from bovine bone. At various heat treatment temperatures, poorly crystalline, partially crystalline and crystalline forms of HA were obtained. PLA composites were prepared by incorporating various forms and contents of HA into PLA matrix. The characteristics of the obtained HA powders affected properties of PLA composites including mechanical properties, morphologies, PLA molecular weight, in vitro bioactivity and in vitro degradation behaviors of the composites. In the case of in vitro bioactivity study, all composites illustrated the induction of bone-like calcium phosphate compounds on their surfaces, especially the PLA/a-HA composites.

Nano-Hydroxyapatite from White Seabass Scales as a Bio-Filler in Polylactic Acid Biocomposite: Preparation and Characterization

“…This assumption supplemented that the strength of PLA/1DP-n could occur from the chemical bonding of −COO and Ca 2+ . However, both samples have mechanical properties which correspond to the tensile strength of human skeletal bones (ranging from 40 – 200 MPa) and the critical mechanical modulus of bone replacement material in non-load bearing sites (ranging from 10 – 1500 MPa) [ 46 ].…”

“…The tensile strength of PLA/nHAp composite films increases with increasing 1DP-nHAp content up to 5 phr as well as the result of Young’s modulus. It indicated good dispersion of nHAp into PLA matrix and strong interfacial actions between the PLA and nHAp [ 46 ]. Therefore, the optimum content of nHAp is 5phr.…”

Clinical and radiographic evaluation of the efficacy of platelet-rich plasma combined with hydroxyapatite bone graft substitutes in the treatment of intra-bony defects in maxillofacial region

“…Recently, bovine bone derived hydroxyapatite has been produced and used as an alternative to synthetic HA with the advantages of being more compatible with human bone, abundant availability, low cost and reducing the volume of biological waste [7][8][9]. However, hydroxyapatite cement when used for secondary craniofacial reconstruction resulted with high infection rates leading to discontinuation of its use.…”

Initial observations of dynamically heated bone

“…In biomedical research, heating bone specimens is essential for producing sterilised hydroxyapatite bioceramics which are frequently employed for medical applications such as allograft and xenograft replacement . Consequently, many researchers have investigated the effect of heat treatment on bone across a wide temperature range (60 – 900 °C) . At higher temperatures (>700 °C), microstructural changes to the mineral may modify the bio‐performance of these materials, potentially to the detriment of the patient.…”