Influence of heavy metals and mineral dusts on superoxide anion release by alveolar macrophages

Gercken, Günther; Labedzka, Maria; Geertz, R.; Gulyas, Holger

doi:10.1016/0021-8502(88)90119-x

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…Contrary to the commonly-observed response by arsenic-exposed HBE and HPF cells, AM cells typically exhibit a dose-dependent reduction in ROS production in the presence of arsenic [128,185,[205][206][207][208]. Soluble trivalent arsenic was notably more potent at inhibiting ROS production than the corresponding pentavalent form, with superoxide inhibition occurring at respective concentrations of 0.1 and 1 µg/mL [208].…”

Section: Arsenic-induced Suppression Of Alveolar Macrophage (Am) Funccontrasting

confidence: 48%

“…In contrast, the slightly soluble trivalent and pentavalent forms showed similar patterns in ROS production with inhibition occurring at a concentration of 10 µg/mL arsenic [128,207]. Gercken et al [205] postulated that the depression of O 2 − (superoxide anion) production by arsenic-exposed AM may be linked with high concentrations of arsenic on the particle surface. Both the studies by Lantz et al [128,208] observed that a 24 h period of arsenic exposure was required to suppress ROS production.…”

Section: Arsenic-induced Suppression Of Alveolar Macrophage (Am) Funcmentioning

confidence: 90%

“…Both the studies by Lantz et al [128,208] observed that a 24 h period of arsenic exposure was required to suppress ROS production. Suppression of ROS production, or a reduction in AM function as demonstrated by others [128,185,205,207,208], may therefore inhibit phagocytosis: an important clearance mechanism of foreign particles, such as dust and bacteria, from the lung. Suboptimal phagocytosis by AM cells has been associated with a decreased ability to clear dead or dying cells from the respiratory system thereby leading to pathological inflammation [209] as well as an increased susceptibility to pulmonary infection such as pneumonia, in respiratory health-compromised individuals [210].…”

Section: Arsenic-induced Suppression Of Alveolar Macrophage (Am) Funcmentioning

confidence: 96%

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Health Effects Associated with Inhalation of Airborne Arsenic Arising from Mining Operations

et al. 2014

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Arsenic in dust and aerosol generated by mining, mineral processing and metallurgical extraction industries, is a serious threat to human populations throughout the world. Major sources of contamination include smelting operations, coal combustion, hard rock mining, as well as their associated waste products, including fly ash, mine wastes and tailings. The number of uncontained arsenic-rich mine waste sites throughout the world is of growing concern, as is the number of people at risk of exposure. Inhalation exposures to arsenic-bearing dusts and aerosol, in both occupational and environmental settings, have been definitively linked to increased systemic uptake, as well as carcinogenic and non-carcinogenic health outcomes. It is therefore becoming increasingly important to identify human populations and sensitive sub-populations at risk of exposure, and to better understand the modes of action for pulmonary arsenic toxicity and carcinogenesis. In this paper we explore the contribution of smelting, coal combustion, hard rock mining and their associated waste products to atmospheric arsenic. We also report on the current understanding of the health effects of inhaled arsenic, citing results from various toxicological, biomedical and epidemiological studies. This review is particularly aimed at OPEN ACCESSGeosciences 2014, 4 129 those researchers engaged in the distinct, but complementary areas of arsenic research within the multidisciplinary field of medical geology.Arsenic is the 20th most abundant element in the earth's crust and may be released into the atmosphere as a result of natural processes and anthropogenic activities [1]. Environmental arsenic is released via chemical and physical weathering processes, biological activity and volcanic emissions, while anthropogenic sources include mining, metal smelting and burning of coal. Annual global arsenic emissions are estimated to be 24,000 t [2], with around 60% originating from copper smelting and coal combustion alone [3]. In some urban and highly industrialized areas, less than 2% of the atmospheric arsenic inputs originate from natural sources [3].Emissions of arsenic-bearing particulate matter (PM) are of particular concern for human populations living in proximity to an emission source. Arsenic and inorganic arsenic compounds are classified as Group 1 carcinogens and are associated with cancers of the lung, bladder, kidney, skin, liver and prostate [2]. It should be noted that within the general population, inhalation is only considered a minor exposure pathway for inorganic arsenic compounds, and ingestion is considered the primary exposure pathway [2]. However, populations living in the vicinity of an arsenic emission source have an increased risk of additional exposure through inhalation of arsenic-contaminated particulates [4][5][6][7][8][9].Despite their substantial contribution to global atmospheric arsenic species, mining operations play an understudied role in the generation of contaminated dust and aerosols [10]. To identify some of the emerging ...

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Section: Arsenic-induced Suppression Of Alveolar Macrophage (Am) Funccontrasting

confidence: 48%

Section: Arsenic-induced Suppression Of Alveolar Macrophage (Am) Funcmentioning

confidence: 90%

Section: Arsenic-induced Suppression Of Alveolar Macrophage (Am) Funcmentioning

confidence: 96%

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Health Effects Associated with Inhalation of Airborne Arsenic Arising from Mining Operations

et al. 2014

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Alveolar Macrophage Damage by Dusts in Vitro is Correlated with Arsenic, Lead and Antimony Contents

Gulyas

Labedzka

Geertz

et al. 1990

Environmental Hygiene II

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Zymosan-induced chemiluminescence of alveolar macrophages: Depression by inorganic dust constituents

Labedzka

Gulyas

Gercken

1991

Arch. Environ. Contam. Toxicol.

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A method has been developed which allows the incubation of alveolar macrophages as weakly affixed monolayers in siliconized glass dishes. Without vigorous mechanical agitation and without using proteolytic enzymes, these cells were subsequently transferred to cuvettes where the zymosan-stimulated chemiluminescence of the suspended cells was measured. In vitro incubations of activated rabbit alveolar macrophage monolayers with airborne dusts from four West German sites (1 to 200 micrograms/10(6) cells), fly ash fractions of a special waste incinerator at Hamburg (50 to 1,000 micrograms/10(6) cells), and quartz dust DQ 12 (5 to 200 micrograms/10(6) cells) resulted in a dose- dependent depression of the zymosan-stimulated chemiluminescence. The depression of chemiluminescence was correlated with particle numbers, estimated dust surface, and antimony and lead masses of the dusts to which the cells were exposed. Cytotoxicity was better correlated with these parameters than with dust mass.

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Influence of heavy metals and mineral dusts on superoxide anion release by alveolar macrophages

Cited by 6 publications

References 5 publications

Health Effects Associated with Inhalation of Airborne Arsenic Arising from Mining Operations

Health Effects Associated with Inhalation of Airborne Arsenic Arising from Mining Operations

Alveolar Macrophage Damage by Dusts in Vitro is Correlated with Arsenic, Lead and Antimony Contents

Zymosan-induced chemiluminescence of alveolar macrophages: Depression by inorganic dust constituents

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