Zymosan-induced chemiluminescence of alveolar macrophages: Depression by inorganic dust constituents

Labedzka, Maria; Gulyas, Holger; Gercken, G.

doi:10.1007/bf01055555

Cited by 10 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, oxolinic acid presents in lower concentrations for a longer period of time in seawater teleosts than freshwater teleosts [ 17 ]. Ishida [ 19 ] reported that oxolinic acid is excreted more slowly in freshwater trout than in seawater trout. Abedini et al .…”

Section: Discussionmentioning

confidence: 99%

Comparison of praziquantel pharmacokinetics and tissue distribution in fresh and brackish water cultured grass carp (ctenopharyngodon idellus) after oral administration of single bolus

et al. 2015

View full text Add to dashboard Cite

BackgroundPraziquantel (PZQ) is an effective pesticide against monogeneans. Its pharmacokinetics in fish may be affected by water environment and temperature. The present study was designed to compare the pharmacokinetics, tissue distribution, and elimination of PZQ in freshwater-acclimated grass carp and brackish water cultured grass carp. Plasma and tissue PZQ concentrations were determined after a single 10 mg/kg oral PZQ dose.ResultsThe datas of plasma and tissues drug concentration was calculated by the software SPSS 13.0. According to the One-Way ANOVA, the results showed that the salinity had a significant effect on the drug concentration of plasma (p < 0.01), muscle (p < 0.01), liver (p < 0.01) and kidney (p < 0.01) in the all sampling time points between the brackish water grass carps and the freshwater grass carps, wherein, PZQ plasma and tissue concentrations in the brackish water group were constantly lower than that in the freshwater group. The peak PZQ levels of plasma, muscle, liver, and kidneys in the brackish water group were 0.76 μg/ml, 0.51 μg/g, 2.7 μg/g, and 2.99 μg/g, respectively; and that in the freshwater group were 0.91 μg/ml, 0.62 μg/g, 3.87 μg/g, and 3.39 μg/g, respectively. The elimination half-lives (t1/2β) in plasma and all tissues of the freshwater group were significantly longer than that in the brackish water group. The elimination half-lives (t1/2β) of plasma, muscle, liver and kidneys in brackish water grass carps were 56.46, 36.17, 15.31, and 132.64 h, respectively; and that in the freshwater grass carps were 71.15, 44.88, 23.86, and 150.23 h, respectively.ConclusionThese findings indicate that water environment affects the tissue distribution and elimination of PZQ in grass carps, the elimination in brackish water grass carps is more rapid than that in fresh water grass carps and tissue concentrations of brackish water grass carps are lower than that in freshwater grass carps after orally administrating the same dosage at the same water temperature. We speculate that the main excretion pathway of the drug is through renal elimination, and the decreased kidney function in brackish water grass carps is likely responsible for the considerable difference in pharmacokinetics between the two groups of grass carps.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of praziquantel pharmacokinetics and tissue distribution in fresh and brackish water cultured grass carp (ctenopharyngodon idellus) after oral administration of single bolus

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Depending on the characteristics of the dust, fly ash fractions induced in vitro in rabbit macrophages depression of zymosan-stimulated chemilumiscence, (Labedzka et al, 1991) or hydrogen peroxide and superoxide anion release (Gulyas et al, 1990). Recent in vitro studies showed a stimulation of human and rat alveolar macrophages exposed to urban air particulates as measured by oxidant radical generation and cytokine production (Becker et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Pathological and Immunological Effects of Respirable Coal Fly Ash in Male Wistar Rats

Dormans

1999

Inhalation Toxicology

View full text Add to dashboard Cite

In this study the effects of inhalatory exposure to coal fly ash on lung pathology and the immune system in rats were examined. Rats were exposed to 0, 10, 30, or 100 mg/m(3) coal fly ash (6 h/day, 5 days/wk) for 4 wk, or to 0 and 100 mg/m(3) for 1 wk, and for 1 wk followed by a recovery in clean air of 3 wk. A concentration-related increase in lung weight was found starting from 30 mg/m(3) coal fly ash. After exposure to 100 mg/m(3), a time-related deposition of free particles in the lungs was observed as well as a time-related number of coal fly ash particles phagocytized in alveolar macrophages. Histological examination revealed increased cellularity in alveolar septa, consisting mainly of mononuclear cell infiltrate, proliferated type II cells, and a slight fibrotic reaction. After a recovery period of 3 wk the histological picture was identical to that after 1 wk of exposure, indicating no significant recovery. No toxicological significant changes were found in the hematological, clinical chemistry, or urine parameters. Effects both on nonspecific defense mechanisms and on specific immune responses were noted. With regard to the immune function in the draining lymph nodes of the lung, a significantly increased number of both T and B lymphocytes was observed. The ratio of both cell types was not changed in either of the groups. In serum of exposed rats a significant increase of up to 150% of the immunoglobulin A (IgA) content was found. The number and phagocytic capacity of macrophages were significantly increased, while the killing of Listeria bacteria per cell ex vivo/in vitro remained unchanged. Natural killer (NK) activity in pulmonary cell suspensions was slightly stimulated in rats exposed for 4 wk to 10 and 30 mg/m(3), whereas an exposure to 100 mg/m(3) resulted in a slight decrease; however, both changes were not significant. In conclusion, the alterations in lung histopathology and immunity, observed in a dose and exposure time relation at concentrations up to and including 100 mg/m(3) coal fly ash, may be considered an adverse response of the host to inhalation of particulate matter. Whether these observed alterations may effect the host resistance must be learned from infection studies.

show abstract

Ambient Air Particles: Effects on Cellular Oxidant Radical Generation in Relation to Particulate Elemental Chemistry

Prahalad

Soukup

Inmon

et al. 1999

Toxicology and Applied Pharmacology

157

View full text Add to dashboard Cite

Zymosan-induced chemiluminescence of alveolar macrophages: Depression by inorganic dust constituents

Cited by 10 publications

References 19 publications

Comparison of praziquantel pharmacokinetics and tissue distribution in fresh and brackish water cultured grass carp (ctenopharyngodon idellus) after oral administration of single bolus

Comparison of praziquantel pharmacokinetics and tissue distribution in fresh and brackish water cultured grass carp (ctenopharyngodon idellus) after oral administration of single bolus

Pathological and Immunological Effects of Respirable Coal Fly Ash in Male Wistar Rats

Ambient Air Particles: Effects on Cellular Oxidant Radical Generation in Relation to Particulate Elemental Chemistry

Contact Info

Product

Resources

About