Influence of heterogeneous and anisotropic tissue conductivity on electric field distribution in deep brain stimulation

Åström, Maria; Lemaire, Jean‐Jacques; Wårdell, Karin

doi:10.1007/s11517-011-0842-z

Cited by 58 publications

(53 citation statements)

References 42 publications

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“…6b) would correspond to axon diameters between 3 and 4 µm. Multiple electric field isolevels have also been used to define and display the stimulation field [43,44]. Such multilevel presentations might be useful in order to visualize tentative activation of different axons.…”

Section: B Visualizationmentioning

confidence: 99%

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Relationship between Neural Activation and Electric Field Distribution during Deep Brain Stimulation

Åström

Diczfalusy

Martens³

et al. 2015

IEEE Trans. Biomed. Eng.

197

199

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1 Abstract-Models and simulations are commonly used to study deep brain stimulation (DBS). Simulated stimulation fields are often defined and visualized by electric field isolevels or volumes of tissue activated (VTA). The aim of the present study was to evaluate the relationship between stimulation field strength as defined by the electric potential, V, the electric field, E, and the divergence of the electric field , and neural activation. Axon cable models were developed and coupled to finite element DBS models in 3D. Field thresholds (VT, ET, and VT) were derived at the location of activation for various stimulation amplitudes (1 to 5 V), pulse widths (30 to 120 µs), and axon diameters (2.0 to 7.5 µm). Results showed that thresholds for VT and VT were highly dependent on the stimulation amplitude while ET, were approximately independent of the amplitude for large axons. The activation field strength thresholds presented in this study may be used in future studies to approximate the VTA during model-based investigations of DBS without the need of computational axon models.

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Section: B Visualizationmentioning

confidence: 99%

“…In addition, patient specific tissue models with axons positioned in a patient-specific manner in the vicinity of the DBS lead have been used extensively in the past [7,14,17,23]. Similar studies could be carried out to investigate the impact of tissue heterogeneity [13] and anisotropy [44] on the stimulation field thresholds.…”

Section: The Dbs Modelmentioning

confidence: 99%

Relationship between Neural Activation and Electric Field Distribution during Deep Brain Stimulation

Åström

Diczfalusy

Martens³

et al. 2015

IEEE Trans. Biomed. Eng.

197

199

View full text Add to dashboard Cite

show abstract

“…Our group has previously used the finite element method (FEM) to investigate the influence on the DBS fields from tissue types such as cystic cavities [18] and white matter heterogeneity and anisotropy [19]. Also, patient-specific models and simulations of DBS have been used to increase the understanding of the response to stimulation for a number of targets including the subthalamic nucleus [20][21][22][23] the globus pallidus internus [24][25][26][27], and the ventral intermedius nucleus of the thalamus for essential tremor [28].…”

Section: Introductionmentioning

confidence: 99%

“…Such patient-specific simulations should preferable take into account both, the tissue's heterogeneity (e.g. differences between grey and white matter) and the anisotropy of the white matter [19]. When studying the differences between lead designs and stimulation modes however, it is an advantage to reduce the number of parameters that can influence the outcome.…”

Section: Introductionmentioning

confidence: 99%

Influence on Deep Brain Stimulation from Lead Design, Operating Mode and Tissue Impedance Changes ? A Simulation Study

Alonso¹,

Hemm-Ode²,

Wårdell³

2015

Brain Disord Ther

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Background: Deep brain stimulation (DBS) systems in current mode and new lead designs are recently available. To switch between DBS-systems remains complicated as clinicians may lose their reference for programming. Simulations can help increase the understanding.Objective: To quantitatively investigate the electric field (EF) around two lead designs simulated to operate in voltage and current mode under two time points following implantation. Methods:The finite element method was used to model Lead 3389 (Medtronic) and 6148 (St Jude) with homogenous surrounding grey matter and a peri-electrode space (PES) of 250 µm. The PES-impedance mimicked the acute (extracellular fluid) and chronic (fibrous tissue) time-point. Simulations at different amplitudes of voltage and current (n=236) were performed using two different contacts. Equivalent current amplitudes were extracted by matching the shape and maximum EF of the 0.2 V/mm isolevel. Results:The maximum EF extension at 0.2 V/mm varied between 2-5 mm with a small difference between the leads. In voltage mode EF increased about 1 mm at acute compared to the chronic PES. Current mode presented the opposite relationship. Equivalent EFs for lead 3389 at 3 V were found for 7 mA (acute) and 2.2 mA (chronic). Conclusions:Simulations showed a major impact on the electric field extension between postoperative time points. This may explain the clinical decisions to reprogram the amplitude weeks after implantation. Neither the EF extension nor intensity is considerably influenced by the lead design. However, the EF distribution is affected by the larger contact of Lead 6148 generating an electric field below the tip.

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“…Tissue heterogeneity and anisotropic properties affect electric field distribution, as has been shown previously. [34] 3.2 Induced electric charges on the vesicle surface…”

Section: Electric Field Distribution Around a Vesiclementioning

confidence: 99%

Deformation but not migration and rotation – a model study on vesicle biomechanics in a uniform DC electric field

Curcuru

2016

JBEI

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Background: Biological cells migrate, deform and rotate in various types of electric fields, which have significant impact on the normal cellular physiology. To investigate electrically-induced deformation, researchers have used artificial giant vesicles that mimic the phospholipid bilayer cell membrane. Containing primarily the neutral molecule phosphatidylcholine, these vesicles deformed under evenly distributed, strong direct current (DC) electric fields. Interestingly, they did not migrate or rotate. A biophysical mechanism underlying the kinematic differences between the biological cells and the vesicles under electric stimulation has not been worked out. Methods: We modeled the vesicle as a leaky, dielectric sphere and computed the surface pressure, rotation torques and translation forces applied on the vesicle by a DC electric field. We compared these measurements with those in a biological cell that contains non-zero, intrinsic charges (carried by the functional groups on the membrane). Results: For both the vesicle and the cell, the electrically-induced charges interacted with the local electric field to generate radial pressure for deformation. However, due to the symmetrical distribution of both the charges and the electric field on the vesicle/cell surface, the electric field could not generate net translation force or rotational torques. For a biological cell, the intrinsic charges carried by the cell membrane could account for its migration and rotation in a DC electric field. Conclusion: Results from this work suggests an interesting control diagram of cellular kinematics and movements by the electric field: cell deformation and migration can be manipulated by directly targeting different charged groups on the membrane. Fate of the cell in an electric field depends not only on the delicately controlled field parameters, but also on the biological properties of the cell.

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Influence of heterogeneous and anisotropic tissue conductivity on electric field distribution in deep brain stimulation

Abstract: Influence of tissue on DBS3

Cited by 58 publications

References 42 publications

Relationship between Neural Activation and Electric Field Distribution during Deep Brain Stimulation

Relationship between Neural Activation and Electric Field Distribution during Deep Brain Stimulation

Influence on Deep Brain Stimulation from Lead Design, Operating Mode and Tissue Impedance Changes ? A Simulation Study

Deformation but not migration and rotation – a model study on vesicle biomechanics in a uniform DC electric field

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