Influence of High Permeability Synthetic Membranes on Gas Exchange and Lung Function during Hemodialysis

Fawcett, S.; Hoenich, Nicholas A.; Woffindin, C.; Ward, M. K.

doi:10.1159/000410770

Cited by 8 publications

(1 citation statement)

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“…Up to now it has been quite difficult to understand whether or not dialysis leukope nia and complement activation have any rel evance with regard to the clinical problems encountered in the dialysis population (chronic pulmonary abnormalities) [41], in fectious susceptibility [24], etc. Perhaps fu ture studies will indicate markers of mem brane and dialysis biocompatibility more re lated to dialysis intolerance and to specific clinical problems.…”

Section: Studies On the Absorption O F Complement Components By Dialysismentioning

confidence: 99%

Leukocytes, Eosinophils and Complement Function during Hemodialysis with Polysulphone and Polymethylmethacrylate Membranes: Comparison with Cuprophan and Polyacrylonitrile

et al. 1988

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The biocompatibility of the two new dialysis membranes, polysulphone (PS) and polymethylmethacrylate (PMMA), was evaluated versus cuprophan (CUP) and polyacrylonitrile (PAN) by studying the in vivo effects of the four different membranes on leukocyte counts, eosinophil levels and complement function both in the presence and absence of dialysis fluid. Complement function was also examined in vitro by studying the generation of chemotactic factors, whole complement activity and C3d serum conversion. Passive absorption of complement fractions by membranes has completed in vitro studies. PS, PMMA and PAN showed a higher biocompatibility than CUP, even if slight differences can be observed: PS showed a PAN-like biocompatibility pattern with a relatively high absorption of complement factors by the membrane and without complement activation. On the other hand, PMMA showed a CUP-like pattern and caused complement activation, even though to a lower intensity than CUP. PMMA biocompatibility appears to stand in-between CUP and the other two synthetic membranes PS and PAN. Our results confirm the important role played by membrane-induced complement activation on hemodialysis leukopenia. Dialysis fluid does not have a significant influence on membrane biocompatibility, but represents the major factor in determining intradialytic eosinopenia. Eosinophils seem to represent a more important marker of dialysis than of membrane biocompatibility.

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Section: Studies On the Absorption O F Complement Components By Dialysismentioning

confidence: 99%