Influence of High Population Density on Contact Dermatitis in Mice.

Okuda, Masahiro; Matsui, Miwako; Hamada, Kazuhiko; Aioi, Akihiro

doi:10.1097/01634989-200103000-00029

Cited by 4 publications

(4 citation statements)

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“…Several chronic cutaneous diseases, such as psoriasis, urticaria and atopic dermatitis, are known to be worsened by systemic stress. These clinical findings are in accordance with experimental results that stress disturbs cutaneous and stratum corneum functions (7, 8), increases inflammatory reactions (9, 10) and suppresses immunity (11–14). In addition, sonic stress, which is a kind of systemic stressor, increases the apoptosis of keratinocytes in murine hair follicles (15).…”

Section: Introductionsupporting

confidence: 90%

Intermittent foot shock stress prolongs the telogen stage in the hair cycle of mice

Aoki

Shibasaki

Kawana

2003

Experimental Dermatology

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Stress significantly influences skin diseases and cutaneous functions. Recently, interactions between stress and skin conditions have been studied in animal models using various systemic stressors. Here, we studied the effect of intermittent foot shock stress on the hair cycle of C57BL/6 mice. After a 2-week period of intermittent foot shock stress, we examined the changes in the depilation-synchronized hair cycle macroscopically and histologically and we also measured the plasma levels of corticosterone. We found that foot shock stress prolonged the telogen stage and delayed the subsequent anagen induction in the hair cycle. The distribution patterns of corticotrophin releasing factor or corticotrophin releasing factor receptor positive cells in the skin of stressed or of control mice were identical with those in the ordinal hair cycle. It is noteworthy that corticotrophin releasing factor positive keratinocytes were observed in the telogen follicles of the stressed mice but were negative in the telogen follicles of the non-stressed mice in this study. Plasma corticosterone levels were significantly higher in the stressed group than in the control group. These results suggest that increased levels of plasma corticosterone may be involved in the mechanism underlying the stress-induced delay of the hair cycle.

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Section: Introductionsupporting

confidence: 90%

Intermittent foot shock stress prolongs the telogen stage in the hair cycle of mice

Aoki

Shibasaki

Kawana

2003

Experimental Dermatology

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“…The skin, as the outermost layer of the body, is readily influenced by external stimuli and seems to have a local stress response system (4,5); that is not only affected by direct external stimuli, but also by systemic physical and psychological stress. Several chronic cutaneous diseases, such as atopic dermatitis, psoriasis and chronic idiopathic urticaria, are exacerbated by psychological stress, and these clinical findings are in accordance with experimental results, showing that stress disturbs cutaneous and stratum corneum functions (6,7), causes increased inflammatory reaction (8,9) and modulates immunity (10–12).…”

Section: Introductionsupporting

confidence: 76%

Foot shock stress prolongs the telogen stage of the spontaneous hair cycle in a non‐depilated mouse model

Katayama

Aoki

Suzuki

et al. 2007

Experimental Dermatology

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Background: There is an increasing evidence to indicate that stress can influence skin disease and cutaneous functions. Previous studies have shown that stress alters the murine hair cycle; however, these studies have been carried out by using mouse models in which the hair cycle is forcibly synchronized after depilation. Objective: To examine whether foot shock stress (FS) changes the spontaneous hair cycle in a non‐depilated animal model, and to evaluate the role of mast cells and substance P (SP) in the influence of stress on the hair cycle. Methods: Changes in the spontaneous hair cycle and the inhibitory effects of a specific SP NK1 receptor antagonist were examined in non‐depilated mice during 3–4 weeks of FS. Results: Foot shock stress prolonged the telogen stage of the hair cycle and delayed the induction of the subsequent anagen stage in the animal model. FS caused an increase in the ratio of de‐granulated mast cells in the skin, an increase in the number of TUNEL‐positive cells, and a decrease in the number of Ki67‐positive cells. The NK1 receptor antagonist, WIN 62577, inhibited these stress responses. Conclusion: Our results strongly support previous work, demonstrating that stress alters active hair‐cycling in vivo through the action of SP.

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“…It was already known that some chronic skin diseases, such as atopic dermatitis, chronic urticaria, psoriasis and alopecia areata, could be aggravated by psychological stress. It has been confirmed experimentally that stress inhibits function of the stratum corneum [3,4], enhances inflammatory responses [5,6], inhibits immune function [7][8][9][10] and disturbs the hair growth cycle [11,12].…”

Section: Introductionmentioning

confidence: 94%

Role of substance P in stress-derived degranulation of dermal mast cells in mice

Kawana

Zai-fu

Nagano

et al. 2006

Journal of Dermatological Science

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Influence of High Population Density on Contact Dermatitis in Mice.

Cited by 4 publications

References 0 publications

Intermittent foot shock stress prolongs the telogen stage in the hair cycle of mice

Intermittent foot shock stress prolongs the telogen stage in the hair cycle of mice

Foot shock stress prolongs the telogen stage of the spontaneous hair cycle in a non‐depilated mouse model

Role of substance P in stress-derived degranulation of dermal mast cells in mice

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