Intermittent foot shock stress prolongs the telogen stage in the hair cycle of mice

Aoki, Eri; Shibasaki, Tamotsu; Kawana, Seiji

doi:10.1034/j.1600-0625.2002.120403.x

Cited by 37 publications

(40 citation statements)

References 42 publications

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“…Blockade of the neurokinin-1 receptor [2], for which SP has the highest affinity, as well as neutralization of NGF abrogate stress-induced neurogenic inflammation [4]. Interestingly, Aoki and Kawana [23], who employed a mouse model of intermittent foot shock stress, independently supported the existence of a stress-associated brain-skin connection by observing a retardation of hair follicle cycling in stressed mice.…”

Section: Introductionmentioning

confidence: 84%

Neuronal plasticity of the “brain–skin connection”: stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nerve growth factor-dependent pathways

et al. 2007

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Emerging research indicates that central-nervous stress perception is translated to peripheral tissues such as the skin not only via classical stress hormones but also via neurotrophins and neuropeptides. This can result in neurogenic inflammation, which is likely to contribute to the triggering and/aggravation of immunodermatoses. Although the existence of such a "brain-skin connection" is supported by steadily increasing experimental evidence, it remains unclear to which extent perceived stress affects the sensory "hardwiring" between skin and its afferent neurons in the corresponding dorsal root ganglia (DRG). In this paper, we provide experimental evidence in a murine model of stress (exposure of C57BL/6 mice to sound stress) that stress exposure, or intracutaneous injection of recombinant nerve growth factor (NGF) to mimic the skin's response to stress, up-regulate the percentage of substance P (SP) + or calcitonin gene-related peptide (CGRP) + sensory neurons in skin-innervating DRG. Further, we show that the number of SP + or CGRP + sensory nerve fibers in the dermis of stressed C57BL/6 mice is significantly increased. Finally, we document that neutralization of NGF activity abrogates

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Section: Introductionmentioning

confidence: 84%

Neuronal plasticity of the “brain–skin connection”: stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nerve growth factor-dependent pathways

et al. 2007

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“…Exposure to sonic stress inhibited the growth of hair shaftproducing (anagen) follicles by premature induction of hair follicle regression (catagen) and by upregulating intrafollicular keratinocyte apoptosis [7]. In a distinct, complementary rodent stress model, mice exposed to foot shock showed a significantly retarded spontaneous switch of telogen follicles into anagen [72].…”

Section: Stress-induced Hair Growth Inhibition In Mice: Leads and Lesmentioning

confidence: 98%

Neuroimmunoendocrine circuitry of the ‘brain-skin connection’

Paus¹,

Theoharides²,

Arck³

2006

Trends in Immunology

304

295

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“…Electrical foot shocks of 0.6-mA intensity of 1-s duration with 30-s inter-shock interval were delivered for 1 h (Aoki et al 2003). …”

Section: Induction Of Foot-shock-induced Acute Stressmentioning

confidence: 99%

Investigating the stress attenuating potential of furosemide in immobilization and electric foot-shock stress models in mice

Kaur

Bali

Singh

et al. 2015

Naunyn-Schmiedeberg's Arch Pharmacol

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The present study was designed to investigate the antistress effect of furosemide (sodium potassium chloride co-transporter inhibitor) in immobilization and foot-shock stress-induced behavioral alterations in the mice. Acute stress was induced in Swiss albino mice either by applying electric foot shocks of 0.6-mA intensity of 1-s duration with 30-s inter-shock interval for 1 h or immobilizing for 150 min. The acute stress-induced behavioral changes were assessed by using actophotometer, hole board, open-field, and social interaction tests. Biochemically, the corticosterone levels were estimated in the serum as a biomarker of hypothalamus-pituitary-adrenal (HPA) axis. Acute stress resulted in the development of behavioral alterations and elevation of the corticosterone levels. Intraperitoneal administration of furosemide (25 and 50 mg/kg) significantly attenuated immobilization and foot-shock stress-induced behavioral changes along with normalization of the corticosterone levels. It may be concluded that furosemide produces beneficial effects in reestablishing the behavioral and biochemical alterations in immobilization and foot-shock-induced acute stress in mice.

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Intermittent foot shock stress prolongs the telogen stage in the hair cycle of mice

Cited by 37 publications

References 42 publications

Neuronal plasticity of the “brain–skin connection”: stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nerve growth factor-dependent pathways

Neuronal plasticity of the “brain–skin connection”: stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nerve growth factor-dependent pathways

Neuroimmunoendocrine circuitry of the ‘brain-skin connection’

Investigating the stress attenuating potential of furosemide in immobilization and electric foot-shock stress models in mice

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