Influence of Homogenization Technique and Blend Ratio on Chitosan/Alginate Polyelectrolyte Complex Properties

Castel, M.; Conzatti, Guillaume; Torrisani, Jérôme; Rouilly, Antoine; Cavalié, Sandrine; Carrère, Nicolas; Tourrette, Audrey

doi:10.1007/s40846-017-0304-7

Cited by 13 publications

(18 citation statements)

References 53 publications

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“…Chitin and chitosan can be combined with poly (vinyl alcohol), alginate, collagen, cellulose acetate, among others to improve their mechanical properties [ 83 , 84 , 85 , 86 ]. Because chitosan is soluble in aqueous acid solutions, it can take different shapes, such as particles, films, sponges, membranes, gels, fibers, including others [ 87 ].…”

Section: Chitin and Chitosan Blend With Other Polymersmentioning

confidence: 99%

Seafood Waste as Attractive Source of Chitin and Chitosan Production and Their Applications

Santos

Marques

Maia

et al. 2020

IJMS

285

123

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Chitosan is a cationic polymer obtained by deacetylation of chitin, found abundantly in crustacean, insect, arthropod exoskeletons, and molluscs. The process of obtaining chitin by the chemical extraction method comprises the steps of deproteinization, demineralization, and discoloration. To obtain chitosan, the deacetylation of chitin is necessary. These polymers can also be extracted through the biological extraction method involving the use of microorganisms. Chitosan has biodegradable and biocompatible properties, being applied in the pharmaceutical, cosmetic, food, biomedical, chemical, and textile industries. Chitosan and its derivatives may be used in the form of gels, beads, membranes, films, and sponges, depending on their application. Polymer blending can also be performed to improve the mechanical properties of the bioproduct. This review aims to provide the latest information on existing methods for chitin and chitosan recovery from marine waste as well as their applications.

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Section: Chitin and Chitosan Blend With Other Polymersmentioning

confidence: 99%

Seafood Waste as Attractive Source of Chitin and Chitosan Production and Their Applications

Santos

Marques

Maia

et al. 2020

IJMS

285

123

View full text Add to dashboard Cite

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“…In addition, swelling ratio of hydrogel films in RAS therapy is an important parameter for mucoadhesive phenomena. Swollen polymers increase surface contact and mechanical entanglement for hydrogen bonding interactions between the polymer and mucous networks [37,38]. In this study, HFs were weighed and soaked in PBS pH 7.4 for two days.…”

Section: Swelling Abilitymentioning

confidence: 99%

α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis

et al. 2019

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Featured Application: This study highlights a novel application of α-mangostin hydrogel film based chitosan-alginate. α-mangostin has been known as an agent for oral cavity therapy. However, α-mangostin is difficult to be delivered directly to the site. This novel application of hydrogel film-based chitosan-alginate have the potential as carriers of α-mangostin for recurrent aphthous stomatitis therapy.Abstract: Many antiseptic drugs, local anaesthetics, and corticosteroids have been used for effective therapy of recurrent aphthous stomatitis (RAS). However, these drugs have harmful side effects. α-mangostin (α-M), a main compound of mangosteen (Garcinia mangostana L.) peel, has been known as a wound healing agent. In addition, hydrogel film as dressings designed to separate mucosal lesions from the oral environment, and improve the effectiveness of RAS therapy. The purpose of this study was to develop α-M hydrogel film based chitosan-alginate (ChAlg/α-M HF) for RAS. The in silico study by Discovery studio visualizer and AutoDock confirmed that hydrogen bonding between Ch, Alg, and α-M occurred. The results of physicochemical characterizations by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) indicated that the ChAlg/α-M HF had a lower crystalline form compared to pure α-M. In addition, ChAlg/α-M HF significantly improved the swelling ratio and tensile strength compared to that of ChAlg HF. Moreover, the existence of Alg increased the degradability of Ch, and closely related to the release of α-M from ChAlg HF. The in vitro release study confirmed that the release of α-M from ChAlg/α-M HF was the Fickian diffusion model. Finally, the mucoadhesive study revealed that ChAlg/α-M HF had a good mucoadhesive property. These results suggest that hydrogel film-based chitosan-alginate have the potential as carriers of α-M for RAS therapy.

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“…The protocol for the elaboration of PEC films was derived from a previous study [21,26]. The sodium alginate was dissolved in water with a concentration of 1.5% w/v and mechanically stirred overnight (500 rpm).…”

Section: Biomaterials Elaboration 221 Alginate/chitosan Pec Film Ementioning

confidence: 99%

Thermosensitive PNIPAM grafted alginate/chitosan PEC

Conzatti

Ayadi

Cavalié

et al. 2019

Applied Surface Science

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Smart biomaterial functionality such as controlled adhesion properties is crucial to limit strip-<>ff injuries. Among functional polymers, poly•N(isopropylacrylamide) (PNIPAM) allows surface properties to be changed depending on the temperature, with a transition of its properties that occurs around 32 •c, called the lower critical solution temperature (LCST). This transition is expected to modify surface interactions. Alginate and chitosan are bio compatible polymers commonly combined as polyelectrolyte complex (PEC) and are suitable for wound dressing applications. As a complex system, however, it is not so trivial to achieve an efficient functionalization. Herein, we elaborated a procedure to functional ize the surface of alginate/chitosan PECs without al tering their intrinsic properties. Fil R revealed that acidic treatment led to a partial decomplexation of the PECs. Therefore, while the N• Hydroxysuccinimide/N•(3-Dim eth ylaminopropyl}-N '-eth ylcarbodümide (N HS/EDC) cou pling usually requires an intermediate pH, we showed that a preliminary acidifi cation seemed to increase the surface grafting effi. ciency. Water contact angle increased fr om 51° to n•, showing that PNIPAM enhanced the surface hydro phobicity. The l.CST transition modified the interaction forces between PNIPAM and mode! surfaces: it revealed an unexpected thermosensitive behaviour as hydrophobie transition favoured interactions with hydrophilic surfaces. It was presumably due to PNIP AM/PEC substrate interactions. Finally, the surface modification did not affect the release properties of the PEC biomaterial.

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Influence of Homogenization Technique and Blend Ratio on Chitosan/Alginate Polyelectrolyte Complex Properties

Cited by 13 publications

References 53 publications

Seafood Waste as Attractive Source of Chitin and Chitosan Production and Their Applications

Seafood Waste as Attractive Source of Chitin and Chitosan Production and Their Applications

α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis

Thermosensitive PNIPAM grafted alginate/chitosan PEC

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