Influence of HTLV-2 infection on hepatitis C virus replication in HIV-positive patients

Toro, Carlos; Bassani, Sylvina; Ríos, Pilar; Jiménez, Victoria; Camino, Nuria; Soriano, Vincent

doi:10.1016/j.jcv.2004.08.013

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…23 Three studies of HCV/HTLV-1 coinfection, all of which were conducted in groups too small to demonstrate differences, have shown inconsistent results with respect to HCV clearance. 24–26 Studies in Japan have found that HCV/HTLV-1 coinfected patients have, on average, increased HCV viremia, 25 which is consistent with another study showing that coinfection had a multiplicative effect on the development of liver disease. 27 In a recent study of patients infected with HCV/HIV/HTLV-1/2 in Brazil, we found that those with triple infection had on average lower ALT levels than patients coinfected with HIV/HCV, suggesting lower hepatic inflammation in the former group.…”

Section: Introductionsupporting

confidence: 69%

Hepatitis C virus infection and spontaneous clearance in HTLV-1 and HIV co-infected patients in Salvador, Bahia, Brazil

Marchand

Bahia

Page

et al. 2015

The Brazilian Journal of Infectious Diseases

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Background While 20–40% of patients with hepatitis C virus (HCV) monoinfection will spontaneously clear the virus, less is known regarding clearance with coinfections. HCV, human immunodeficiency virus (HIV), and human T-cell lymphotrophic virus 1 and 2 (HTLV-1/2) coinfection occurs due to shared routes of transmission and is prevalent in Brazil. Objectives To compare the proportion of patients who have spontaneously cleared HCV in patients with HCV monoinfection to patients coinfected by HCV/HIV, or HCV/HIV/HTLV-1. Methods Using medical records from two clinics in Salvador, Brazil, including demographic data and serological markers of HCV, HIV and HTLV-I/II, cross-sectional data was obtained from 197 patients. Patients who were anti-HCV positive and HCV RNA negative, and who did not receive HCV treatment were defined as having cleared infection. Results Nineteen patients (9.5%) showed evidence of spontaneous HCV clearance; with clearance in 9 of 108 (8.3%) patients in the HCV monoinfected group, 5 of 68 (7.4%) patients with HCV/HIV, and 5 of 21 (23.8%) patients with HCV/HIV/HTLV. Demographic data were not associated with HCV clearance status. Patients coinfected with both HIV and HTLV-1 had increased odds (5.50; 95% CI 1.00, 30.17) of spontaneous clearance of HCV compared with patients who were HIV negative or of unknown HIV status. Conclusion Our study found that patients coinfected with HIV and HTLV-1 were more likely to spontaneously clear hepatitis C virus than patients with HIV/HCV or HCV alone. The effects of HTLV coinfection on the immune response of such patients may be associated with these findings.

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Section: Introductionsupporting

confidence: 69%

Hepatitis C virus infection and spontaneous clearance in HTLV-1 and HIV co-infected patients in Salvador, Bahia, Brazil

Marchand

Bahia

Page

et al. 2015

The Brazilian Journal of Infectious Diseases

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“…Finally, the decrease in the number of cells that support efficient HIV infection can be another mechanism of the suppression of HIV-1. In a simple way, these cells may be just killed or blocked in their cell cycle, as reported for MV infection (Moss et al, 2002(Moss et al, , 2009, or, in a more complex process, cells may diminish their activation as reported for HIV-1/HTLV-2-coinfection (Toro et al, 2005).…”

Section: Short Reviewmentioning

confidence: 95%

War and Peace between Microbes: HIV-1 Interactions with Coinfecting Viruses

Lisco

Vanpouille

Margolis

2009

Cell Host & Microbe

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HIV-1 disrupts the homeostatic equilibrium between the host and coinfecting microbes, facilitating reactivation of persistent viruses and invasion by new viruses. These viruses usually accelerate HIV disease but occasionally create conditions detrimental for HIV-1. Understanding these phenomena may lead to anti-HIV-1 strategies that specifically target interactions between HIV-1 and coinfecting viruses.

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“…Neurologic complications, such as peripheral neuropathy and myelopathy were more common in coinfected IDU than in IDU infected with only HIV [19]. Coinfection with HCV with HTLV-2 or HIV increases HCV RNA viral loads, but the clinical consequences of coinfection have not yet been well defined [20,21].…”

Section: Introductionmentioning

confidence: 99%

HTLV-2 infection in injection drug users in King County, Washington

Zunt

Tapia

Thiede

et al. 2006

Scandinavian Journal of Infectious Diseases

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Human T-cell lymphotropic virus type 2 (HTLV-2) is endemic in injection drug users (IDU), and native American populations in the Americas. Transmission is associated with high-risk injection and sexual practices. A cohort of 2561 IDU in King County, Washington completed 2 study visits over 1 y. HTLV-2 infection was detected in 190 (7.4%) of 2561 IDU, and 13 (7.8 cases per 1000 person-y) incident infections occurred during the study. Prevalent infection was associated with female gender, non-white race, longer duration as IDU, having a tattoo, combined injection of heroin and cocaine, and with serologic evidence of hepatitis B and C infection. Seroconversion was more common in women, and was associated with African American race, heterosexual identity and longer duration as IDU. In conclusion, increased risk of HTLV-2 infection was associated with non-white race, and injection drug of choice, suggesting injection networks may play an important role in transmission of HTLV-2. The high correlation of HTLV-2 infection with HCV infection suggests the major route of transmission in IDU is via injection practices. Additional studies are needed to examine the clinical manifestations of HTLV-2 infection, as well as the clinical and virological manifestations of HTLV-2/HCV coinfection.

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Influence of HTLV-2 infection on hepatitis C virus replication in HIV-positive patients

Cited by 5 publications

References 6 publications

Hepatitis C virus infection and spontaneous clearance in HTLV-1 and HIV co-infected patients in Salvador, Bahia, Brazil

Hepatitis C virus infection and spontaneous clearance in HTLV-1 and HIV co-infected patients in Salvador, Bahia, Brazil

War and Peace between Microbes: HIV-1 Interactions with Coinfecting Viruses

HTLV-2 infection in injection drug users in King County, Washington

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