2019
DOI: 10.15407/ubj91.05.025
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Influence of human HB-EGF secreted form on cells with different EGFR and ErbB4 quantity

Abstract: pivotal role in many cellular processes, but its effect differs from one cell type to another and remains not fully understood. the aim of this work was to investigate the dependence between the rate of hB-eGF mediated cell proliferation and activation of EGFR and ErbB4 receptors. Therefore, the effects of human recombinant sHB-EGF (rsHB-EGF) on the proliferation of cell lines with different EGFR and ErbB4 quantity and ratio, as well as activation of the marK-cascade p38 and erK1/2 (p42/44) kinases, were analy… Show more

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Cited by 3 publications
(3 citation statements)
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“…It contains EGF-like and heparin-binding domains allowing interactions with heparin and cell-surface heparin sulfate. [1] It can activate human epidermal growth factor receptors 1 and 4 resulting in a multitude of cell responses, including cellular proliferation, migration, adhesion, and differentiation. HB-EGF levels can increase in response to different forms of injuries as well as extracellular stimuli, such as lysophosphatidic acid, retinoic acid, and 17-estradiol [2].HB-EGF plays a critical role in tissue repair and regeneration.…”
mentioning
confidence: 99%
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“…It contains EGF-like and heparin-binding domains allowing interactions with heparin and cell-surface heparin sulfate. [1] It can activate human epidermal growth factor receptors 1 and 4 resulting in a multitude of cell responses, including cellular proliferation, migration, adhesion, and differentiation. HB-EGF levels can increase in response to different forms of injuries as well as extracellular stimuli, such as lysophosphatidic acid, retinoic acid, and 17-estradiol [2].HB-EGF plays a critical role in tissue repair and regeneration.…”
mentioning
confidence: 99%
“…HB-EGF levels can increase in response to different forms of injuries as well as extracellular stimuli, such as lysophosphatidic acid, retinoic acid, and 17-estradiol [2].HB-EGF plays a critical role in tissue repair and regeneration. It promotes cutaneous wound healing, hepatocyte proliferation after partial hepatectomy, intestinal anastomosis strength, alveolar regeneration after pneumonectomy, neurogenesis after ischemic injury, bladder wall thickening in response to urinary tract obstruction, and protects against ischemia/reperfusion injury in many cell types [1,3,4].Aim. To obtain bioactive recombinant human HB-EGF and investigate its proliferation capacity.…”
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confidence: 99%
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