Influence of hydroxypropyl-β-cyclodextrin on the photostability and antiradical activity of Trolox

Carlotti, Maria Eugenia; Sapino, Simona; Marino, Silvia; Ugazio, Elena; Trotta, Francesco; Vione, Davide; Chirio, Daniela; Cavalli, Roberta

doi:10.1007/s10847-008-9420-x

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…Recently, there are some reports that HP-bCyD and methyl-b-CyD improved photo stability and antiradical activity of Trolox, a derivative of VE, through the formation of complexation. [26][27][28] Therefore, it is possible that the photo stability of VE in the tablets containing HP-b-CyD prepared by a molding method may be increased. Hereafter, further investigation for chemical and photo stability of VE in the tablets should be required.…”

Section: Effects Of Ve Content On Appearance Hardness and Disintegramentioning

confidence: 99%

Potential Use of 2-Hydroxypropyl-.BETA.-cyclodextrin for Preparation of Orally Disintegrating Tablets Containing dl-.ALPHA.-Tocopheryl Acetate, an Oily Drug

Motoyama

Nagatomo

Elazim

et al. 2009

CHEMICAL & PHARMACEUTICAL BULLETIN

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Section: Effects Of Ve Content On Appearance Hardness and Disintegramentioning

confidence: 99%

Potential Use of 2-Hydroxypropyl-.BETA.-cyclodextrin for Preparation of Orally Disintegrating Tablets Containing dl-.ALPHA.-Tocopheryl Acetate, an Oily Drug

Motoyama

Nagatomo

Elazim

et al. 2009

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…According to previous literature, the potential oxidative effect of 9d was evaluated toward the oxidation of linoleic acid, a carboxylic acid with two double bonds as a model lipid substrate. The lipoperoxidation of linoleic acid, incorporated in dipalmitoylphosphatidylcholine (DPPC) liposomes was determined using the TBA assay [20, 21]. DPPC liposomes were prepared with the thin film evaporation method and used to mimic a phospholipid bilayer, and to dissolve linoleic acid.…”

Section: Methodsmentioning

confidence: 99%

Novel broad spectrum virucidal molecules against enveloped viruses

et al. 2018

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Viral infections are an important cause of death worldwide. Unfortunately, there is still a lack of antiviral drugs or vaccines for a large number of viruses, and this represents a remarkable challenge particularly for emerging and re-emerging viruses. For this reason, the identification of broad spectrum antiviral compounds provides a valuable opportunity for developing efficient antiviral therapies. Here we report on a class of rhodanine and thiobarbituric derivatives displaying a broad spectrum antiviral activity against seven different enveloped viruses including an HSV-2 acyclovir resistant strain with favorable selectivity indexes. Due to their selective action on enveloped viruses and to their lipid oxidation ability, we hypothesize a mechanism on the viral envelope that affects the fluidity of the lipid bilayer, thus compromising the efficiency of virus-cell fusion and preventing viral entry.

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“…However, the advent of new functional substances, and the expectations of users, have lead to the introduction of more complex vehicles, which not only stabilize and release the active molecule at the target site, but also give the preparation an acceptable and pleasant feel, thus combining efficacy and aesthetics. Examples of this approach involve solid lipid nanoparticles [85,86], nanosponges [87], cyclodextrins [88][89][90], and more recently mesoporous silica nanoparticles [91]. Ordered mesoporous silica is a new development in nanotechnology: this material is now being produced on an industrial scale in a growing number of commercial products, its fabrication being simple, cost-effective, and controllable.…”

Section: ) Squalene-derived Nanoparticlesmentioning

confidence: 99%

Recent studies on the delivery of hydrophilic drugs in nanoparticulate systems

Berlier

Battaglia

Brusa

et al. 2016

Journal of Drug Delivery Science and Technology

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This review discusses some approaches developed by the Turin University Pharmaceutical Technology group to enhance the entrapment efficiency of mainly hydrophilic molecules within nanoparticulate systems, and to optimize their delivery. Many attempts have been made to increase, either passively or actively, the delivery of hydrophilic drugs. One approach consists of their association to liposomes, in some cases by developing lipophilic prodrugs of anticancer hydrophilic molecules, and encapsulating them in liposomes; in some cases these are then further conjugated with suitable vectors, to increase targeting efficiency. The transformation of hydrophilic drugs into lipophilic prodrugs can also overcome problems of poor entrapment efficiency, and the frequentlyobserved rapid release from polymer nanocarriers, for example nanospheres or nanocapsules obtained from various PEGylated poly(alkylcyanoacrylate) copolymers. Strategies have also been developed to enhance hydrophilic drug entrapment in solid lipid nanoparticles (SLN). Of these, hydrophobic ion pairing (HIP) was designed to enable various antitumor drugs to be entrapped in SLN produced by the coacervation method. The w/o/w emulsion solvent dilution technique may also be employed to entrap peptide drugs, such as insulin, directly in the inner aqueous phase. Another strategy entails covalent linkage of antitumoral and antiviral drugs to a squalenoyl-derived chain; this produces bioconjugates that spontaneously self-assemble in an aqueous medium as stable nanoparticles. Another development comprises mesoporous silica nanoparticles with immobilized hydrophilic antioxidants, for topical applications. Ordered mesoporous silica (MCM-41) nanoparticles were complexed with hydrophilic antioxidants (Trolox ® or rutin) employing different inclusion procedures, varying solvent and pretreatment of the silica matrix; on exposure to UV illumination, mesoporous silica significantly improved stability over time. Finally, polymer-shelled and perfluoropentane-cored nanobubbles have been designed as versatile multifunctional carriers for the delivery of gases, drugs and genes; the size range is below 500 nm, with shell thickness in the 30-50 nm range.(lectins), or macromolecular conjugates to tumor tissues. Further, collaboration with several European research groups lead to the development of particulate delivery systems (liposomes, polymer nanoparticles) and, more recently, to the squalenoylation platform. Colloidal systems, such as liposomes, nanoparticles, and microemulsions, have mainly been reported in the literature for use as carriers of hydrophobic drugs. Delivery of hydrophilic molecules is a challenging goal, which requires multidisciplinary approaches. This review essentially focused on the various strategies that may be employed to deliver hydrophilic active substances. Many drugs are hydrophilic, and many of these are low-molecular weight molecules (less than 500 Da). According to the United States Pharmacopeia (USP), hydrophilic drugs are classified in the range ve...

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Influence of hydroxypropyl-β-cyclodextrin on the photostability and antiradical activity of Trolox

Cited by 8 publications

References 15 publications

Potential Use of 2-Hydroxypropyl-.BETA.-cyclodextrin for Preparation of Orally Disintegrating Tablets Containing dl-.ALPHA.-Tocopheryl Acetate, an Oily Drug

Potential Use of 2-Hydroxypropyl-.BETA.-cyclodextrin for Preparation of Orally Disintegrating Tablets Containing dl-.ALPHA.-Tocopheryl Acetate, an Oily Drug

Novel broad spectrum virucidal molecules against enveloped viruses

Recent studies on the delivery of hydrophilic drugs in nanoparticulate systems

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