Influence of
            <i>HLA</i>
            Class I and
            <i>HLA-KIR</i>
            Compound Genotypes on HIV-2 Infection and Markers of Disease Progression in a Manjako Community in West Africa

Yindom, L M; Leligdowicz, Aleksandra; Martin, Maureen P.; Gao, Xiaojiang; Ying, Qi; Zaman, Syed M A; Loeff, Maarten Schim van der; Tienen, Carla van; Jaye, Assan; Aveika, Akum; Worwui, Archibald; Diatta, Mathurin; Vincent, Tim; Whittle, Hilton; Rowland‐Jones, Sarah; Walton, Robert; Carrington, Mary

doi:10.1128/jvi.00116-10

Cited by 43 publications

(34 citation statements)

References 41 publications

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“…Interestingly, no HLA allele associated with control of infection has been found in HIV-2 infection. It was suggested by Yindom et al (56) that this might be because HIV-2 infection is easier to control compared with HIV-1 and therefore that less stringent requirements for control may not have led to the selection of "protective" epitopes that are restricted by specific HLA molecules during HIV-2 infection. In addition, unlike the partial control exerted by CD8 + T cells in HIV-1 infection (59), the robust CD8 + T cell control of HIV-2 could limit the emergence of escape variants and therefore abrogate the requirement for HLA class I molecules that possess sufficient flexibility to adapt to new variants.…”

Section: Discussionmentioning

confidence: 99%

Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2–Infected Controllers

Angin

Wong

Papagno

et al. 2016

The Journal of Immunology

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Compared with HIV-1, HIV-2 infection is characterized by a larger proportion of slow or nonprogressors. A better understanding of HIV-2 pathogenesis should open new therapeutic avenues to establish control of HIV-1 replication in infected patients. In this study, we studied the production of CD8+ T cells and their capacity for viral control in HIV-2 controllers from the French ANRS CO5 HIV-2 cohort. HIV-2 controllers display a robust capacity to support long-term renewal of the CD8+ T cell compartment by preserving immune resources, including hematopoietic progenitors and thymic activity, which could contribute to the long-term maintenance of the CD8+ T cell response and the avoidance of premature immune aging. Our data support the presence of HIV-2 Gag–specific CD8+ T cells that display an early memory differentiation phenotype and robust effector potential in HIV-2 controllers. Accordingly, to our knowledge, we show for the first time that HIV-2 controllers possess CD8+ T cells that show an unusually strong capacity to suppress HIV-2 infection in autologous CD4+ T cells ex vivo, an ability that likely depends on the preservation of host immune resources. This effective and durable antiviral response probably participates in a virtuous circle, during which controlled viral replication permits the preservation of potent immune functions, thus preventing HIV-2 disease progression.

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Section: Discussionmentioning

confidence: 99%

Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2–Infected Controllers

Angin

Wong

Papagno

et al. 2016

The Journal of Immunology

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“…No strong correlation with any KIR gene (including KIR3DS1 ) was observed, except for a trend for protective effect of KIR2DL2/KIR2DS2/C1 genotype (Yindom et al, 2010). …”

Section: Viral Infectionsmentioning

confidence: 99%

Killer Cell Immunoglobulin-Like Receptor Gene Associations with Autoimmune and Allergic Diseases, Recurrent Spontaneous Abortion, and Neoplasms

Kuśnierczyk¹

2013

Front. Immun.

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Killer cell immunoglobulin-like receptors (KIRs) are a family of cell surface inhibitory or activating receptors expressed on natural killer cells and some subpopulations of T lymphocytes. KIR genes are clustered in the 19q13.4 region and are characterized by both allelic (high numbers of variants) and haplotypic (different numbers of genes for inhibitory and activating receptors on individual chromosomes) polymorphism. This contributes to diverse susceptibility to diseases and other clinical situations. Associations of KIR genes, as well as of genes for their ligands, with selected diseases such as psoriasis vulgaris and atopic dermatitis, rheumatoid arthritis, recurrent spontaneous abortion, and non-small cell lung cancer are discussed in the context of NK and T cell functions.

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“…The importance of NK cells in HIV-1 infection is suggested by genetic associations between co-expression of KIR3DS1 or KIR3DL1 alleles encoding highly-expressed KIR3DL1 proteins and HLA-Bw480I, and slow HIV-1 disease progression [67, 68] (although similar associations are not observed in HIV-2 infection) [69]. KIR3DS1/HLA-Bw480I is associated with establishment of a low persisting viral load, indicating that it exerts protective effects during AHI [70].…”

Section: Activation and Subversion Of Systemic Innate Responses Durinmentioning

confidence: 99%

Innate immunity in acute HIV-1 infection

Borrow

2011

Current Opinion in HIV and AIDS

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Purpose of review Acute HIV-1 infection (AHI) is comprised of the eclipse phase, during which the transmitted virus struggles to avoid eradication and achieve amplification/spread; the expansion phase when virus disseminates and undergoes exponential replication associated with extensive CD4+ T cell destruction; and the containment phase when set-point levels of viremia and immune activation are established. The importance of interactions between HIV-1 and innate responses in determining events throughout AHI is increasingly recognised, and is reviewed here. Recent findings During the eclipse phase HIV-1 subverts dendritic cell functions to promote its replication at mucosal sites and employs multiple strategies to minimise control by type 1 interferons. Systemic virus dissemination is associated with widespread activation of innate responses, which fuels HIV-1 replication. To minimise the protective effects of innate responses HIV-1 resists control by natural killer cells and may impair innate regulation of adaptive responses. Innate responses remain chronically activated after HIV-1 containment, which is thought to drive HIV-1 pathogenesis. Summary Innate responses are pivotal determinants of events at all stages of AHI. Increased understanding of mechanisms involved in innate control of HIV-1 and pathways regulating innate activation during HIV-1 infection could facilitate development of novel approaches to combating this infection.

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Influence of HLA Class I and HLA-KIR Compound Genotypes on HIV-2 Infection and Markers of Disease Progression in a Manjako Community in West Africa

Cited by 43 publications

References 41 publications

Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2–Infected Controllers

Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2–Infected Controllers

Killer Cell Immunoglobulin-Like Receptor Gene Associations with Autoimmune and Allergic Diseases, Recurrent Spontaneous Abortion, and Neoplasms

Innate immunity in acute HIV-1 infection

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