Influence of indomethacin on endotoxin-induced changes in gastrointestinal myoelectrical activity and some haematological and clinical parameters in the conscious piglet

Abstract

The effect of indomethacin, administered intravenously at 5 mg/kg, on the changes in gastrointestinal myoelectrical activity, rectal body temperature, clinical appearance and some haematological parameters induced by intravenous bolus injection of endotoxin, at 10 micrograms/kg, was examined in conscious piglets with electrodes implanted in the antrum pylori, duodenum, jejunum and ileum. Indomethacin inhibited the endotoxin-induced febrile response and the accompanying clinical signs. However, it was without influence on the induced leukopenia and shift to the left. Indomethacin both delayed the onset of and shortened the endotoxin-induced increase in the duration of the antral inhibitory phase and the duodenal phase I activity. It therefore appears that prostanoids are probably not the main factors involved in the endotoxin-induced haematological and gastrointestinal myoelectrical activity changes in the piglet.

Dose‐response investigation of oral ketoprofen in pigs challenged with Escherichia coli endotoxin

“…Although the endotoxin dose was moderate, two pigs died spontaneously despite treatment with a low dose of ketoprofen. Higher endotoxin doses of 10 to 20 µg/kg have been used in pigs with no reports of mortality (De Saedeleer and others 1992, Myers and others 2010). The cause of the deaths remained uncertain.…”

Central tumour necrosis factor‐α mediates the early gastrointestinal motor disturbances induced by lipopolysaccharide in sheep

“…pretreatment with indomethacin reduces fever and GI hypomotility evoked by i.v. LPS 23 . As PGs act as local regulatory agents that modulate GI motility, these results could be because LPS‐induced GI alterations are mediated at least in part through the release of PGs at the peripheral level.…”

“…Lipopolysaccharide and cytokines have been reported to alter digestive motility through the release of prostaglandins (PGs). Peripheral administration of the cyclooxygenase inhibitor indomethacin and of other non‐steroidal anti‐inflammatory drugs (NSAIDs), reduces GI motor alterations evoked by LPS in rats, 8 piglets 23 and goats 24,25 and by IL‐1 α in goats, 26 and completely prevents the inhibition of gastric emptying evoked by intracisternal IL‐1 β in rats 18 . Although these studies do not establish whether PGs are released in the CNS or in the periphery, other results suggest a role for PGs in the CNS.…”

Role of prostaglandins in lipopolysaccharide effects on K+‐induced contractions in rabbit small intestine

“…Furthermore, indomethacin reverts the LPS effects on the ACh-induced contractions in rabbit intestine (Rebollar et al 2002). Similarly, peripheral administration of indomethacin reduces changes in gastrointestinal motor activity evoked by LPS in rats (Pons et al 1989) and piglets (De Saedeleer et al 1992).…”

“…Similarly, peripheral administration of indomethacin reduces changes in gastrointestinal motor activity evoked by LPS in rats (Pons et al. 1989) and piglets (De Saedeleer et al. 1992).…”