The radial installation deviation of the turbine runner will change the gap flow between the upper crown and the lower ring seal, which will affect the radial force of the runner and the hydraulic excitation characteristics of the top cover. This research focuses on the 1GW Francis turbine on the right bank of the Baihetan hydropower station. The pressure distribution along the circumference of the top cover was analyzed, and the effects of deviations on the specific generation of hydraulic excitation forces were studied. This research shows that the increase in radial deviation will slightly reduce the output and efficiency, and the radial force on the runner increases parabolically. When the radial deviation is 1.5 mm, the radial force is 5.9 times higher compared to the case without any deviation, and the radius of the fitting circle of the radial force behavior trajectory increases with the increase in radial deviation. In addition, the radial deviation has little effect on the internal flow of the runner and the pressure distribution in the upper crown chamber. The dominant frequency components at the upstream monitoring points include fn, 15 fn, 24 fn, and 30 fn. The dominant frequency components at the downstream monitoring points include the blade passing frequencies of 15 fn and 30 fn. However, with the increase in radial deviation, the fluctuation amplitudes exhibit an asymmetric distribution, the uniformity of the pressure distribution in the circumferential direction of the labyrinth seal area becomes significantly worse, and the waveform of the downstream monitoring points changes significantly and presents a non-uniform distribution in one rotation cycle.