Influence of intraluminal brachytherapy dose on complications in the treatment of esophageal cancer

Kumar, M U; Swamy, Kumara; Supe, Sanjay S.; Anantha, N.

doi:10.1016/0360-3016(93)90525-z

Cited by 18 publications

(2 citation statements)

References 13 publications

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“…To date, the aging of population has been progressing and elderly patients with esophageal cancer are more likely to be treated with CRT or RT alone, instead of surgery, for comorbidities and treatment risks [29,30]. Salvage PDT is reported to be a safer and more effective treatment option than other minimally invasive treatments such as re-irradiation or endoluminal brachytherapy in elderly patients [31,32]. Finally, we hope that salvage PDT using talaporfin sodium will be recognized as a promising salvage treatment for esophageal cancer with local failure after CRT and function as a treatment of choice in the future.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy Using Talaporfin Sodium for Local Failure after Chemoradiotherapy or Radiotherapy for Esophageal Cancer: A Single Center Experience

Ishida

Osawa

Miyazu

et al. 2020

JCM

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A phase II study of second-generation photodynamic therapy (PDT) using talaporfin sodium has shown excellent treatment results for esophageal cancer with local failure after chemoradiotherapy (CRT) or radiotherapy (RT). However, only a few studies have reported this therapy in clinical practice. This study aimed to confirm the efficacy and safety of salvage PDT using talaporfin sodium for esophageal cancer in various clinical situations. Twelve patients with esophageal cancer with local failure after definitive CRT or RT who underwent PDT using talaporfin sodium were enrolled from April 2016 to January 2020. Overall, 10 patients (83.3%) achieved a local complete response. No skin phototoxicity was observed, but esophageal stricture occurred in five patients (41.7%). Esophageal stricture was improved with endoscopic balloon dilation in all patients, and subsequent analysis found no significant factors causing esophageal stricture after PDT. Two patients with synchronous tumors were successfully rescued by combination therapy with endoscopic submucosal dissection. Two patients with carcinoma in situ of larger than 1/2 circumference were rescued by repeated PDT. The 2-year overall survival was 80.0% (95% confidence interval 0.409–0.946). PDT using talaporfin sodium was an effective and safe salvage treatment for esophageal cancer with local failure after CRT or RT in various clinical situations.

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Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy Using Talaporfin Sodium for Local Failure after Chemoradiotherapy or Radiotherapy for Esophageal Cancer: A Single Center Experience

Ishida

Osawa

Miyazu

et al. 2020

JCM

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“…Использование БТ высокой мощности дозы в качестве буста после дистанционной ЛТ на пищевод и регионарные зоны с СОД 46-50 Гр было оценено в ряде клинических исследований (табл. 1) [8][9][10][11][12][13][14][15]. В исследованиях представлен значительный разброс в величинах РОД и СОД при проведении дистанционной ЛТ и БТ.…”

Section: рефератunclassified

Immediate Results of Concurrent Chemoradiotherapy with Inoperable Esophageal Squamous Cell Carcinoma

Гладилина

Shabanov²,

Zakhidova³

et al. 2021

jour

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Background: The incidence of esophageal cancer is increasing. In this connection, the search for the most effective methods of treating this disease continues. In most patients, esophageal cancer is diagnosed at III– IV stages of the disease. Currently, the standard of treatment for inoperable patients is chemo radiotherapy. Brachytherapy is one of the perspective methods of radiation therapy. Using of brachytherapy in the complex treatment of patients with esophageal cancer makes possible to increase the radiation dose without increasing the risk of complications after treatment.Methods: The study included 20 patients with inoperable esophageal cancer (most of them with III stages, 60 %). The age of the patients is from 51 to 89 years, ECOG performance status ½ (25 %/75 %), dysphagia score 1/2/3–4 (25 %,50 %, 25 %). All patients were diagnosed with esophageal squamous cell carcinoma. Most patients were with tumor in the middle third of the esophagus (70 %). The greatest length of the tumor was 10 cm. On the first stage of treatment patients underwent external-beam radiation therapy 46 Gy in 2 Gy fractions with simultaneous chemotherapy. After that, brachytherapy was performed (single dose of 5 Gy, 2 fractions with an interval of 6–7 days, 62,8 Gy (EQD2, α/β = 10 Gy).Results: Patients received therapy support for cardiovascular and lung diseases and nutritional support before, during and following chemoradiotherapy. There were no patients with hematological toxicity grade 3–4. Esophagitis grade 2 was noted in 40 % of patients, grade 1 in 60 % of patients. Esophagitis resolved on its own 2 weeks after completion of therapy. Complete tumor regression was observed in 10 % of patients, partial regression in 80 % of patients, stabilization of tumor process was observed in 10 % of patients. All patients have a poor QOL due to physical and psychological disorders. The general health situation and physical function after 3 months of treatment was improved compared to the prior to treatment period.

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Grundlagen und Technik der Brachytherapie

Fritz¹,

Roth²,

Pötter³

et al.

Strahlentherapie

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Influence of intraluminal brachytherapy dose on complications in the treatment of esophageal cancer

Cited by 18 publications

References 13 publications

Photodynamic Therapy Using Talaporfin Sodium for Local Failure after Chemoradiotherapy or Radiotherapy for Esophageal Cancer: A Single Center Experience

Photodynamic Therapy Using Talaporfin Sodium for Local Failure after Chemoradiotherapy or Radiotherapy for Esophageal Cancer: A Single Center Experience

Immediate Results of Concurrent Chemoradiotherapy with Inoperable Esophageal Squamous Cell Carcinoma

Grundlagen und Technik der Brachytherapie

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