Influence of Ketamine on Catecholamine Secretion in the Perfused Rat Adrenal Medulla

Ko, Young-Yeob; Jeong, Yong‐Hoon; Lim, Dong-Yoon

doi:10.4196/kjpp.2008.12.3.101

Cited by 6 publications

(4 citation statements)

References 57 publications

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“…Alternatively, the anaesthesia and surgical procedure may have uncontrolled consequences on the basal release. Although ketamine does not modify basal catecholamine secretion 45 , a direct measurement of plasma catecholamines, in a freely moving mouse submitted or not to various stress paradigms, will be necessary to definitely answer this question. Although a direct cell-cell communication through gap junctions has been described in many endocrine/neuroendocrine tissues [46][47][48][49] , including the adrenal medulla 6,7,11 , its contribution to hormone secretion in vivo has been unambiguously established so far only for insulin 50,51 and renin 49,52 .…”

Section: Discussionmentioning

confidence: 99%

Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo

et al. 2013

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“…Thiopental administered at subanesthetic and anesthetic doses leads to oxidative stress in the brain striatum, likely because of the suppressed production of adrenaline, which causes systemic hypotension and associated high-risk complications [ 18 ]. Published studies have shown that, unlike ketamine, thiopental suppresses release of catecholamines [ 36 ] and decreases the amount of adrenaline in rats even at subanesthetic doses [ 16 ]. Furthermore, it was reported that hyperalgesia occurred in the animals receiving thiopental alone, while analgesia was observed in the animals receiving thiopental combined with adrenaline.…”

Section: Discussionmentioning

confidence: 99%

The effects of ketamine and thiopental used alone or in combination on the brain, heart, and bronchial tissues of rats

Ahıskalıoğlu¹,

Aydin²,

Ahıskalıoğlu³

et al. 2018

aoms

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IntroductionWe compared the side effects of ketamine and thiopental used alone and of a ketamine/thiopental combination dose on the brain,heart, and bronchial tissues of rats.Material and methodsThree groups received intraperitoneal injections of 30 mg/kg ketamine (K-30); 15 mg/kg thiopental (T-15); or of both in combination (KTSA). These doses were doubled in another set of study groups (K-60, T-30, and KTA groups, respectively). Optimal anesthesia duration was examined in all groups.ResultsAnesthesia did not occur with 30 mg/kg ketamine or 15 mg/kg thiopental. However, when used alone ketamine and thiopental led to oxidative stress in the striatum, heart, and bronchial tissues. Conversely, combined administration of anesthetics and subanesthetic doses were found not to create oxidative stress in any of these areas. The highest level of adrenaline in blood samples collected from the tail veins was measured in the KTA-60, and the lowest amount in the T-30. Creatine kinase activity was highest in the KTA-60 group (p < 0.001). When we compared for all 5 groups to untreated control group; the creatine kinase-MB activities were significiantly different in K-30, T-15 and T-30 (p < 0.001).ConclusionsThe studied doses of ketamine led to oxidative stress by increasing the amount of adrenaline. Thiopental increased oxidative stress with decreases in adrenaline. A longer anesthetic effect with minimal adverse events may be achieved by ketamine and thiopental in combination.

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“…This reveals that the amount of blood ADR should not fall below a certain level for TPS to be able to establish analgesic activity. TPS has also been reported to suppress catecholamine production in the literature [ 14 ]. Previous studies have also evaluated an increase rise in pain threshold as an analgesic activity and have reported that ADR induces significant analgesic activity [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

The relation between the effect of a subhypnotic dose of thiopental on claw pain threshold in rats and adrenalin, noradrenalin and dopamine levels

et al. 2015

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Thiopental sodium (TPS) needs to be applied together with adrenalin in order to establish its analgesic effect in general anesthesia. We aimed to investigate the effect of TPS on the claw pain threshold in rats and evaluated its relationship with endogenous adrenalin (ADR), noradrenalin (NDR), and dopamine (DOP) levels. Intact and adrenalectomized rats were used in the experiment. Intact animals were divided into the following groups: 15 mg/kg TPS (TS), 0.3 mg/kg ADR+15 mg/kg TPS (ATS) and 0.3 mg/kg ADR alone (ADR). Adrenalectomized animals were divided into the following groups: 15 mg/kg TPS (A-TS), 0.3 mg/kg ADR+15 mg/kg TPS (A-ATS) and 0.3 mg/kg ADR alone (A-ADR). Claw pain threshold and blood ADR, NDR, and DOP levels were measured. The TS group’s claw pain threshold was found low. However, the claw pain thresholds of the ATS and ADR groups increased significantly. In the A-TS group, the pain threshold decreased compared with normal, and in the A-ATS and A-ADR groups, the pain threshold increased. TPS reduced the blood ADR levels in intact rats; however, no significant changes were observed in the NDR and DOP levels. #TPS provides hyperalgesia by reducing the production of ADR in rats. The present study shows that to achieve analgesic activity, TPS needs to be applied together with ADR.

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Influence of Ketamine on Catecholamine Secretion in the Perfused Rat Adrenal Medulla

Cited by 6 publications

References 57 publications

Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo

Gap junction signalling is a stress-regulated component of adrenal neuroendocrine stimulus-secretion coupling in vivo

The effects of ketamine and thiopental used alone or in combination on the brain, heart, and bronchial tissues of rats

The relation between the effect of a subhypnotic dose of thiopental on claw pain threshold in rats and adrenalin, noradrenalin and dopamine levels

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