Influence of Large Peritumoral Vessels on Outcome of Radiofrequency Ablation of Liver Tumors

Lu, David; Raman, Steven S.; Limanond, Piyaporn; Aziz, Donya; Economou, James S.; Busuttil, Ronald W.; Sayre, James

doi:10.1097/01.rvi.0000092666.72261.6b

Cited by 435 publications

(298 citation statements)

References 25 publications

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“…The efficacy of thermal ablation is diminished for tumors adjacent to large vessels, most likely because of the heat sink effect (23,24). Correspondingly, the cold sink effect in cryotherapy has been reported for lesions adjacent to blood vessels (25).…”

Section: Biological Effect Of Ire In Live Animalsmentioning

confidence: 99%

Irreversible electroporation: the evolution of a laboratory technique to be used in interventional oncology

Deipolyi

Golberg

Yarmush

et al. 2014

Diagn Interv Radiol

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Electroporation involves applying electric field pulses to cells, leading to the alteration or destruction of cell membranes. Irreversible electroporation (IRE) creates permanent defects in cell membranes and induces cell death. By directly targeting IRE to tumors, percutaneous nonthermal ablation is possible. The history of IRE, evolution of concepts, theory, biological applications, and clinical data regarding its safety and efficacy are discussed.

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Section: Biological Effect Of Ire In Live Animalsmentioning

confidence: 99%

Irreversible electroporation: the evolution of a laboratory technique to be used in interventional oncology

Deipolyi

Golberg

Yarmush

et al. 2014

Diagn Interv Radiol

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“…For lesions at the liver surface or those abutting the colon or stomach, 5% dextrose can be instilled in the plane between lesion and the bowel to prevent thermal injury to these structures. Major portal or hepatic vein branches adjacent to the lesion can be temporarily balloon occluded to prevent the heat sink effect and thereby optimizing the zone of ablation [44][45][46].…”

Section: Methodsmentioning

confidence: 99%

Interventional Radiological Treatment of Hepatocellular Carcinoma: An Update

2011

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Hepatocellular carcinoma is the commonest primary liver tumor and its incidence is on an increase. Transplantation and surgical resection are the gold standard curative treatment options but less than 20%patients are surgical candidates because of advanced liver disease and/ or co-morbidities.Various interventional radiological procedures have been developed and intensively investigated for treatment of inoperable HCC.This review summarizes the various interventional radiological treatments in HCC including patient selection, procedural considerations and response evaluation. Transarterial chemoembolization, radioembolization and radiofrequency ablation are mainly discussed.

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“…The use of central bile duct cooling during RFA of periductal HCC was effective in preventing thermal injury of bile duct (62). However, the presence of the 'heatsink effect' may affect the complete ablation of the tumor near the major vessels, and therefore increase the chance of local recurrence after RFA (63,64).…”

Section: Radiofrequency Ablation (Rfa)mentioning

confidence: 99%

Bridging and downstaging therapy in patients suffering from hepatocellular carcinoma waiting on the list of liver transplantation

She¹,

Cheung²

2016

Transl. Gastroenterol. Hepatol.

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Hepatocellular carcinoma (HCC) is a common primary malignancy worldwide especially in the patients with the background of chronic liver disease. Liver transplantation (LT) is the only curative treatment effective for both malignancy as well as the cirrhosis and portal hypertension. Unfortunately, living donor is not always possible and the deceased graft is scarce. Neoadjuvant therapies, therefore, have been developed as a downstaging treatment to try to downstage the tumor within the transplant criteria, or as a bridging therapy to control the tumor growth in patients while waiting in the transplant list. This paper reviewed the common modalities used as bridging and downstaging therapies for patients suffering from HCC before undergoing LT.

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Influence of Large Peritumoral Vessels on Outcome of Radiofrequency Ablation of Liver Tumors

Cited by 435 publications

References 25 publications

Irreversible electroporation: the evolution of a laboratory technique to be used in interventional oncology

Irreversible electroporation: the evolution of a laboratory technique to be used in interventional oncology

Interventional Radiological Treatment of Hepatocellular Carcinoma: An Update

Bridging and downstaging therapy in patients suffering from hepatocellular carcinoma waiting on the list of liver transplantation

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