Influence of laser irradiation on endogenous hyaluronan in rabbit iris and aqueous humor

Koralewska-Makár, Anna; Johnsson, Cecilia; Bruun, Anitha; Stenevi, Ulf; Ehinger, Berndt

doi:10.1034/j.1600-0420.2001.790513.x

Cited by 2 publications

(3 citation statements)

References 34 publications

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“…The protracted increase of iris hyaluronan concentration in comparison with aqueous hyaluronan in response to iris trauma has been demonstrated already in our previous studies (Koralewska‐Makár et al. 1998, 2001).…”

Section: Discussionsupporting

confidence: 75%

“…1987; Unger 1990). Moreover, the concentration of hyaluronan in the iris increases after an iris trauma (peripheral iridectomy or laser irradiation), with maximum levels seen at day 2 (Koralewska‐Makár et al. 1998, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…The physiological role of endogenous hyaluronan appears to be associated with trauma and inflammation. In our previous studies, we were able to show a rapid increase of hyaluronan concentration in the iris after peripheral iridectomy and after laser irradiation (Koralewska‐Makár et al. 1998, 2001).…”

mentioning

confidence: 92%

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Effects of sympathetic denervation on the hyaluronan content of the anterior segment in the normal and traumatized rabbit eye

Koralewska-Makár

Johnsson

Bruun

et al. 2002

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To determine whether there is any involvement of sympathetic nerves in the regulation of ocular hyaluronan production in the normal and traumatized rabbit iris. Methods: Unilateral sympathetic denervation was performed by removing the right superior cervical ganglion. Hyaluronan concentrations in the iris and aqueous were measured with a radiometric assay at various time intervals after denervation. Peripheral iridectomy was also performed in both denervated and non-denervated eyes. Results: Hyaluronan concentrations in the iris tissue after denervation were observed to have increased after 1 day, reaching a peak of 129.6 ∫ 5.7 mg/g wet weight at day 3. Two weeks later, hyaluronan concentrations had fallen back to normal levels. Ocular trauma with peripheral iridectomy in denervated eyes caused an increase of hyaluronan content of up to 253.5 ∫ 30.5 mg/g wet weight, which was not significantly different from hyaluronan concentrations observed after the same trauma in non-denervated eyes. Conclusion: Cervical sympathetic denervation results in a moderate increase of the hyaluronan content in the rabbit iris and does not appear to influence the hyaluronan response of the iris to trauma.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%