Influence of Lecithin on Mitochondrial DNA and Age‐Related Hearing Loss

Seidman, Michael D.; Khan, Mohammad Javed; Tang, Wenxue; Quirk, Wayne S.

doi:10.1067/mhn.2002.127627

Cited by 101 publications

(77 citation statements)

References 15 publications

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“…SOD1 deficiency in mice induces cochlear hair cell degeneration and loss of spiral ganglion cells and nerve fibers, with ARHI as a consequence [McFadden et al, 1999a[McFadden et al, , b, 2001. Lecithin, a polyunsaturated phosphatidylcholine responsible for SOD activation, has a protective effect and preserves the hearing abilities in ageing subjects [Seidman et al, 2002b].…”

Section: Do Mitochondrial Mutations and Reactive Oxygen Species Contrmentioning

confidence: 99%

The Complexity of Age-Related Hearing Impairment: Contributing Environmental and Genetic Factors

Eyken¹,

Camp²,

Laer³

2007

Audiol Neurotol

262

205

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Age-related hearing impairment (ARHI) is the most common sensory impairment seen in the elderly. It is a complex disorder, with both environmental as well as genetic factors contributing to the impairment. The involvement of several environmental factors has been partially elucidated. A first step towards the identification of the genetic factors has been made, which will result in the identification of susceptibility genes, and will provide possible targets for the future treatment and/or prevention of ARHI. This paper aims to give a broad overview of the scientific findings related to ARHI, focusing mainly on environmental and genetic data in humans and in animal models. In addition, methods for the identification of contributing genetic factors as well as possible future therapeutic strategies are discussed.

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Section: Do Mitochondrial Mutations and Reactive Oxygen Species Contrmentioning

confidence: 99%

The Complexity of Age-Related Hearing Impairment: Contributing Environmental and Genetic Factors

Eyken¹,

Camp²,

Laer³

2007

Audiol Neurotol

262

205

View full text Add to dashboard Cite

show abstract

“…In preclinical studies NTFactor has been used to reduce age-related functional damage. Using rodents Seidman et al (2002) found that NTFactor prevented hearing loss associated with aging and shifted the threshold hearing from 35-40 dB in control, aged rodents to 13-17 dB. They also found that NTFactor preserved cochlear mitochondrial function and prevented aging-related mitochondrial DNA deletions found in the cochlear.…”

Section: Molecular Replacement Of Oxidized Membrane Components and Itmentioning

confidence: 95%

“…They also found that NTFactor preserved cochlear mitochondrial function and prevented aging-related mitochondrial DNA deletions found in the cochlear. Thus NTFactor was successful in preventing age-associated hearing loss and reducing mitochondrial damage and DNA deletions in rodents (Seidman et al 2002). In clinical studies Lipid Replacement Therapy has been used to reduce fatigue and protect cellular and mitochondrial membranes from oxidative damage by ROS/RNS (reviewed in Nicolson, 2003;2010).…”

Section: Molecular Replacement Of Oxidized Membrane Components and Itmentioning

confidence: 99%

Nutritional Supplements for Cancer-Associated

Nicolson¹

2012

Topics in Cancer Survivorship

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“…Compelling evidence exists from experiments in the authors' laboratory demonstrating that aged rats supplemented with a diet rich in phosphatidylcholine have improved auditory sensitivity when compared with placebo-supplemented rats. Furthermore, study of the subjects' mitochondrial function reveals a statistically significant improvement in mitochondrial energy production in the treated groups compared with placebo (Seidman et al, [11]). …”

Section: Vitamin B 3 (Niacin)mentioning

confidence: 99%