Influence of low-dose anaesthetic agents on ventilatory control: where do we stand?

Dahan, A.; Teppema, Luc J.

doi:10.1093/bja/83.2.199

Cited by 17 publications

(12 citation statements)

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“…Since it is expected that the relationship of hemodynamic response to CO 2 and anesthesia is a mechanism that is species, age, and clinical condition dependent, it may be inaccurate to extrapolate from studies on animals. 97,98 Therefore, in our conclusions, we rely on the fact that all infants were anesthetized in the same manner. Our work is accurate for comparison to other studies with this limitation.…”

Section: Discussionmentioning

confidence: 99%

Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects

et al. 2010

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Abstract. We employ a hybrid diffuse correlation spectroscopy ͑DCS͒ and near-infrared spectroscopy ͑NIRS͒ monitor for neonates with congenital heart disease ͑n =33͒. The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow ͑rCBF DCS ͒; and oxygen metabolism ͑rCMRO 2 ͒. Concurrent measurements with arterial spin-labeled magnetic resonance imaging ͑rCBF ASL-MRI , n =12͒ cross-validate rCBF DCS against rCBF ASL-MRI , showing good agreement ͑R = 0.7, p = 0.01͒. The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population.

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Section: Discussionmentioning

confidence: 99%

Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects

et al. 2010

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“…Two previous studies examined the influence of propofol on the hypoxic ventilatory response. 20 Our study gives little information on the site of action of propofol with respect to its effects on normoxic resting ventilation and AHR. They observed an 80% depression of the ventilatory response in eight male volunteers.…”

Section: Influence Of Propofol On the Ventilatory Response To Acute Hmentioning

confidence: 85%

Propofol for Monitored Anesthesia Care

Nieuwenhuijs¹,

Sarton

Teppema

et al. 2000

Anesthesiology

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The depression of acute hypoxic response results from an effect of propofol at peripheral or central sites involved in respiratory control or secondary to the induction of sedation or hypnosis by propofol. The relative increase in hypoxic ventilatory decline is possibly related to propofol's action at the gamma-aminobutyric acid A (GABA(A)) receptor complex, causing increased GABAergic inhibition of ventilation during sustained (but not intermittent) hypoxia.

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“…Therefore, Dahan and Teppema proposed that monitoring of PCO 2 (e.g., using portable, easily applied transcutaneous devices) should become standard practice in recovery rooms and general wards [115]. …”

Section: Discussionmentioning

confidence: 99%

Volatile Anaesthetic Depression of the Carotid Body Chemoreflex-Mediated Ventilatory Response to Hypoxia: Directions for Future Research

Pandit

2014

Scientifica

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In assessing whether volatile anaesthetics directly depress the carotid body response to hypoxia it is necessary to combine in meta-analysis studies of when it is “functionally isolated” (e.g., recordings are made from its afferent nerve). Key articles were retrieved (full papers in English) and subjected to quantitative analysis to yield an aggregate estimate of effect. Results from articles that did not use such methodology were assessed separately from this quantitative approach, to see what could be learned also from a nonquantitative overview. Just 7 articles met the inclusion criteria for hypoxia and just 6 articles for hypercapnia. Within these articles, the anaesthetic (mean dose 0.75, standard deviation (SD) 0.40 minimum alveolar concentration, MAC) statistically significantly depressed carotid body hypoxic response by 24% (P = 0.041), but a similar dose (mean 0.81 (0.42) MAC) did not affect the hypercapnic response. The articles not included in the quantitative analysis (31 articles), assessed qualitatively, also indicated that anaesthetics depress carotid body function. This conclusion helps direct future research on the anaesthetic effects on putative cellular/molecular processes that underlie the transduction of hypoxia in the carotid body.

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Influence of low-dose anaesthetic agents on ventilatory control: where do we stand?

Cited by 17 publications

References 0 publications

Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects

Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects

Propofol for Monitored Anesthesia Care

Volatile Anaesthetic Depression of the Carotid Body Chemoreflex-Mediated Ventilatory Response to Hypoxia: Directions for Future Research

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