Influence of low-level laser therapy on inflammation, collagen fiber maturation, and tertiary dentin deposition in the pulp of bleached teeth

Terayama, Amanda Miyuki; Benetti, Francine; Lopes, Jair; Barbosa, Jéssica Galbiati; Silva, Isabela Joane Prado; Sivieri-Araújo, Gustavo; Briso, André Luiz Fraga; Cintra, Luciano Tavares Ângelo

doi:10.1007/s00784-020-03258-9

Cited by 15 publications

(27 citation statements)

References 57 publications

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“…After colour selection, the program automatically calculated the marked area of each collagen fibre type inside the pulp chamber. Greenish‐yellow fibres were classified as immature and thin, whilst yellowish‐red fibres were considered mature and thick (Benetti et al, 2020; Cintra et al, 2017; Terayama et al, 2020).…”

Section: Methodsmentioning

confidence: 99%

Influence of ethylenediaminetetraacetic acid irrigation on the regenerative endodontic procedure in an immature rat molar model

et al. 2022

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Aim: To analyse the influence of ethylenediaminetetraacetic acid (EDTA) on the repair process in immature rat molars after a regenerative endodontic procedure (REP). Methodology:The lower first molars of 12 4-week-old Wistar rats underwent pulpectomy in the mesial root and were divided into the following groups: sodium hypochlorite (NaOCl; n = 6) -the mesial canals were irrigated with 2.5% NaOCl for 5 min, and NaOCl-EDTA (n = 6) -the canals were irrigated with 2.5% NaOCl, followed by 17% EDTA for 5 min each. After evoking bleeding using a size 10 K-file, the cavities were sealed. Three molars on the untreated side were randomly used as control (control-15 d; n = 3), and three molars from the other three rats untreated were used as immediate control (n = 3). After 15 days (NaOCl, NaOCl-EDTA and control-15 d groups) or immediately (control-immediate), the animals were euthanized, and the teeth were subjected to histologic evaluation of tissue regeneration and presence of collagen fibres. Mann-Whitney U-test was used (p < .05). Results:The experimental groups had newly formed cementum-like tissue and increased root length and thickness. Half of the specimens in NaOCl-EDTA group showed apical foramen closure, whilst the NaOCl group had partial apical closure.The experimental groups showed inflammatory infiltrate extending mainly to the medium third of the root canal. These parameters were similar between experimental groups (p > .05). Newly formed connective tissue in the pulp space was significantly higher in the NaOCl-EDTA group than in NaOCl group (p < .05). Regarding the collagen fibres, the NaOCl-EDTA group had more collagen fibres in the root tip, but there was no significant difference compared to NaOCl group, and both groups showed greater amount of immature fibres in this area; in the centre of the apical third of root canal, there was equivalence between mature and immature fibres from both groups (p > .05).

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Section: Methodsmentioning

confidence: 99%

Influence of ethylenediaminetetraacetic acid irrigation on the regenerative endodontic procedure in an immature rat molar model

et al. 2022

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“…In another study by Ferreira et al [15], it was found that diode laser with a 670 nm wavelength and energy density of 4 J/cm 2 increased the expression of proteins such as collagen, fibronectin, and tenascin. These proteins are able to perform a crucial function in calcified tissue formation as well as the differentiation of fibroblasts and odontoblasts during dentinogenesis [42], [43].…”

Section: Discussionmentioning

confidence: 93%

“…Collagen which forms approximately 90% of the dentin organic composition is made by the odontoblasts before being secreted into pre-dentin as a network of collagen fibers which later act as a scaffold for mineral crystals [16]. Fibronectin and tenascin may also play a role in dentin mineralization and in the ability of fibroblast differentiation to form mineralized tissue [15], [17].…”

Section: Discussionmentioning

confidence: 99%

“…More than 1 study assessed the outcomes of using PBM in conjunction with direct pulp capping [12], [13] and its effect on regeneration potential of dental pulp complex [14]. PBM elevates the secretion of certain proteins that are of high value in the dentin bridge formation cycle in addition to another set of proteins that signal the initiation of dentinogenesis [15], [16], [17].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Mineral Trioxide Aggregate and Photobiomodulation on Pulp Capping of Dogs’ Teeth

Abdelgawad

Shalash

Zaazou

et al. 2022

Open Access Maced J Med Sci

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AIM: The present study assessed the effect of mineral trioxide aggregate (MTA) and photobiomodulation (PBM) on pulp capping of exposed pulp of dogs’ teeth. METHODS: Forty-eight teeth in three mongrel dogs were randomly divided into two major study groups; Group I where MTA was used as a pulp capping agent and Group II in which both MTA+PBM were used. The groups were equally subdivided according to the observation period following completion of pulp capping into Subgroup (A) 1 week, Subgroup (B) 2, and Subgroup (C) 16 weeks. The teeth were examined for histological inflammatory response as well as dentine bridge formation. RESULTS: With regard to inflammatory response at 1 week significantly, less intense inflammation was observed in MTA+PBM (Group II) compared to the MTA (Group I) for the same time period with no significant difference for between Group I and Group II for other time intervals. As for dentin bridge formation, PBM+MTA groups showed statistically significant thicker dentine bridge formation at 16 weeks than MTA alone group for the same time period with no significant difference for between Group I and Group II for other time intervals. CONCLUSIONS: Under the conditions of this study, PBM appeared to be a beneficial adjunct in dental pulp capping procedures in which MTA was the pulp capping material.

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“…First, LLLT may immediately change patients' self-perception by modulating neuronal physiology in terms of varying the axonal flow, cytoskeletal organisation, and adenosine triphosphate production in sensory nerves [68][69][70]. Second, the effect of LLLT on inflammation may play a role in the interim alleviation of DH since studies suggested there is a potential relationship between DH and micro-inflammation within dentine-pulp complexes [71][72][73][74]. The third theory is more explicable for persistent DH relief, as light irradiation may help increase blood vasculature in pulp tissues and stimulate the viability of odontoblasts; they both contribute to the deposition of secondary dentine and reduction of dentin permeation [75][76][77][78].…”

Section: Discussionmentioning

confidence: 99%

Effects of low-level light therapy on dentin hypersensitivity: a systematic review and meta-analysis

Shan

McGrath

et al. 2021

Clin Oral Invest

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Objective To investigate the treatment efficacy of low-level light therapy on dentin hypersensitivity. Materials and methods Following the PRISMA guideline, six electronic databases supplemented with bibliographies were searched till December 2020. Two reviewers performed the screenings independently with a reliability assessment. Studies fulfilling the pre-registered eligibility criteria were included for risk-of-bias assessment and data synthesis. Results Thirty-five articles ultimately informed this systematic review based on the eligibility criteria and underwent risk-of-bias assessment (ĸ = 0.86). Quantitative results were deduced by meta-analysis of 20 randomised controlled trials: LLLT showed favourable outcomes compared to placebos for immediate (SMD: 1.09, 95% CI: 0.47 to 1.70), interim (SMD: 1.32, 95% CI: 0.41 to 2.23), and persistent efficacies (SMD: 2.86, 95% CI: 1.98 to 3.74). However, substantial heterogeneity existed among included studies (I2: 64–95%). Regarding comparisons with other desensitising strategies, LLLT showed no significant benefits in DH alleviation over others except fluorides for interim efficacy (SMD: 0.31, 95% CI: 0.10 to 0.52) and persistent efficacy (SMD: 0.45, 95% CI: 0.03 to 0.86). Conclusions This systematic review shows that LLLT has positive immediate, interim, and persistent DH-treatment efficacies compared with placebo. No superior treatment effects of LLLT were observed except fluoride agent use. Further studies are warranted—RCTs with low risk of bias, consistent technical settings, comprehensive assessments, and long follow-up periods. Clinical relevance This systematic review bridges a critical research gap by analysing clinical evidence in the DH-alleviating efficacy of LLLT in comparison with placebo and other in-office desensitising strategies.

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Influence of low-level laser therapy on inflammation, collagen fiber maturation, and tertiary dentin deposition in the pulp of bleached teeth

Cited by 15 publications

References 57 publications

Influence of ethylenediaminetetraacetic acid irrigation on the regenerative endodontic procedure in an immature rat molar model

Influence of ethylenediaminetetraacetic acid irrigation on the regenerative endodontic procedure in an immature rat molar model

Efficacy of Mineral Trioxide Aggregate and Photobiomodulation on Pulp Capping of Dogs’ Teeth

Effects of low-level light therapy on dentin hypersensitivity: a systematic review and meta-analysis

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