2022
DOI: 10.1155/2022/2754727
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Influence of Lower Extremity Deep Venous Thrombosis in Cerebral Infarction on Coagulation Index and Thromboelastogram and Its Risk Factors

Abstract: Cerebral infarction is a serious brain injury disease, which is mainly caused by the blockage of blood circulation in patients’ brains; thus, the patient’s brain appears ischemia and hypoxia state, and large-scale nerve cell death occurs immediately. The aim of this study was to explore the influence of lower extremity deep venous thrombosis (LEDVT) on coagulation indexes and thromboelastogram (TEG) after cerebral infarction. Altogether, 67 patients with cerebral infarction complicated with LEDVT in our hospit… Show more

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Cited by 7 publications
(5 citation statements)
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“…Thromboelastography (TEG) monitors the coagulation process from the whole dynamic process of platelet aggregation, coagulation, and fibrinolysis, which can dynamically reflect coagulation factors, fibrinogen, platelet function, and fibrinolysis, and is a sensitive test for overall evaluation of coagulation, which can provide strong evidence for the existence of the hypercoagulable state in thrombotic diseases [ 13 , 14 ]. The literature [ 15 ] reported that changes in TEG were sensitive predictors of the risk of progression to cerebral infarction in patients with cerebral ischemia and that several of its indicators were positively correlated with the occurrence of cerebral infarction. Based on the above research theories, it is hypothesized that thromboelastography can assess the risk of END by rapidly and comprehensively detecting the coagulation status of patients with ACI.…”
Section: Prefacementioning
confidence: 99%
“…Thromboelastography (TEG) monitors the coagulation process from the whole dynamic process of platelet aggregation, coagulation, and fibrinolysis, which can dynamically reflect coagulation factors, fibrinogen, platelet function, and fibrinolysis, and is a sensitive test for overall evaluation of coagulation, which can provide strong evidence for the existence of the hypercoagulable state in thrombotic diseases [ 13 , 14 ]. The literature [ 15 ] reported that changes in TEG were sensitive predictors of the risk of progression to cerebral infarction in patients with cerebral ischemia and that several of its indicators were positively correlated with the occurrence of cerebral infarction. Based on the above research theories, it is hypothesized that thromboelastography can assess the risk of END by rapidly and comprehensively detecting the coagulation status of patients with ACI.…”
Section: Prefacementioning
confidence: 99%
“…The study also pointed out that TEG can effectively and accurately evaluate the platelet aggregation rate of ACI patients and timely determine the reactivity of antiplatelet drugs in patients with cerebral infarction; to guide the clinical development of individualized antiplatelet therapy, timely use of highly responsive antithrombotic drugs to replace easily resistant drugs, and to improve the therapeutic effect of antithrombotic therapy in patients, it can reduce the drug dose to a certain extent, improve the fibrinolysis and coagulation function of the body, and minimize the high bleeding risk of combined drugs. [16,17] Jin et al [18] also pointed out that personalized treatment plans based on TEG monitoring can guide the clinical use of highly responsive antiplatelet drugs, regulate blood microcirculation in the ischemic area of the brain, inhibit cerebral thrombosis, reduce inflammation, improve endothelial function, and improve quality of life. In addition, TEG can dynamically monitor the changes in blood viscosity during the coagulation process of patients and analyze the entire coagulation fibrinolysis process in graphical form, providing more comprehensive and intuitive indicators, helping physicians comprehensively grasp coagulation function and monitor the patient's disease treatment status.…”
Section: Discussionmentioning
confidence: 99%
“…The lower extremity deep venous thrombosis (LEDVT) is diagnosed clinically based on venography, the gold standard. 9 Even though both techniques have a high diagnostic value, the latter is quite intrusive and expensive, while the former lacks the ability to diagnose intraperitoneal venous embolism. 10 In addition, ultrasound is not a routine and is only performed before discharge for patients with symptoms following major orthopedic surgery.…”
Section: Introductionmentioning
confidence: 99%