Influence of maternal one carbon metabolites on placental programming and long term health

Nema, Juhi; Joshi, Nikita; Sundrani, Deepali; Joshi, Sadhana

doi:10.1016/j.placenta.2022.02.022

Placenta

2022

DOI: 10.1016/j.placenta.2022.02.022

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Influence of maternal one carbon metabolites on placental programming and long term health

Juhi Nema¹,

Nikita Joshi²,

Deepali Sundrani³

et al.

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Cited by 4 publications

References 110 publications

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Paternal programming of fetoplacental and offspring metabolic disorders

Capobianco,

Pirrone

2023

Placenta

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Paternal programming of fetoplacental and offspring metabolic disorders

Capobianco,

Pirrone

2023

Placenta

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Maternal Vitamin B12 in Pregnancy and Placental Development

Arcot,

Walker,

Gallagher

et al. 2024

Journal of Nutrition and Metabolism

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Vitamin B12, or cobalamin, is an essential nutrient required for diverse physiological functions secondary to its role as a critical cofactor for two mammalian enzymes, methionine synthase and methylmalonyl‐CoA mutase. While essential throughout all life stages, several pathways that require vitamin B12, including hematopoiesis, myelination, and DNA/histone methylation, are particularly critical during pregnancy and fetal development. This narrative review aims to describe vitamin B12 in pregnancy, with emphasis on the placenta’s role in ensuring adequate nutrition of the fetus and impacts of vitamin B12 deficiency on placental development and function. Our literature search included preclinical model systems and human cohorts and interventions. Our review identified evidence of B12 deficiency resulting in impaired placental development, greater placental inflammation, and modulation of placental docosahexaenoic acid concentration, collectively suggestive of vitamin B12 deficiency as a determinant of both maternal and fetal health outcomes. Heterogeneity in study design complicated generalization of findings. Future studies should consider selecting a B12 marker that is relatively stable across pregnancy, such as holotranscobalamin, while accounting for important confounders such as maternal folate.

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The Role of One-Carbon Metabolism and Methyl Donors in Medically Assisted Reproduction: A Narrative Review of the Literature

Sfakianoudis,

Zikopoulos,

Grigoriadis

et al. 2024

IJMS

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One-carbon (1-C) metabolic deficiency impairs homeostasis, driving disease development, including infertility. It is of importance to summarize the current evidence regarding the clinical utility of 1-C metabolism-related biomolecules and methyl donors, namely, folate, betaine, choline, vitamin B12, homocysteine (Hcy), and zinc, as potential biomarkers, dietary supplements, and culture media supplements in the context of medically assisted reproduction (MAR). A narrative review of the literature was conducted in the PubMed/Medline database. Diet, ageing, and the endocrine milieu of individuals affect both 1-C metabolism and fertility status. In vitro fertilization (IVF) techniques, and culture conditions in particular, have a direct impact on 1-C metabolic activity in gametes and embryos. Critical analysis indicated that zinc supplementation in cryopreservation media may be a promising approach to reducing oxidative damage, while female serum homocysteine levels may be employed as a possible biomarker for predicting IVF outcomes. Nonetheless, the level of evidence is low, and future studies are needed to verify these data. One-carbon metabolism-related processes, including redox defense and epigenetic regulation, may be compromised in IVF-derived embryos. The study of 1-C metabolism may lead the way towards improving MAR efficiency and safety and ensuring the lifelong health of MAR infants.

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Influence of maternal one carbon metabolites on placental programming and long term health

Cited by 4 publications

References 110 publications

Paternal programming of fetoplacental and offspring metabolic disorders

Paternal programming of fetoplacental and offspring metabolic disorders

Maternal Vitamin B12 in Pregnancy and Placental Development

The Role of One-Carbon Metabolism and Methyl Donors in Medically Assisted Reproduction: A Narrative Review of the Literature

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