Influence of Methionine on Toxicity of Fluoride in the Liver of Rats

Błaszczyk, Iwona; Birkner, Ewa; Kasperczyk, Sławomir

doi:10.1007/s12011-010-8664-7

Cited by 20 publications

(7 citation statements)

References 31 publications

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“…Thus Pr supplement in the diet may not alter the serum AKP activity. As a sensitive index for liver pathological changes, SGPT activity was significantly increased in serum of rabbits treated with high F, which is coincident with results of previous investigation (Blaszczyk et al, 2011;Kanbur et al, 2009). Meanwhile, Pr or Ca supplementation significantly decreased the activity of SGPT, exerting a protective role.…”

Section: Discussionsupporting

confidence: 88%

“…differentially (Lu et al, 2010). In rat liver, enzymes of the antioxidative system, such as superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), were significantly inhibited after NaF exposure (Blaszczyk et al, 2011). Due to the importance of liver health for body metabolism, prevention and treatment of F-induced liver lesion have become a matter of major concern.…”

Section: Introductionmentioning

confidence: 99%

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Ameliorative effect of protein and calcium on fluoride-induced hepatotoxicity in rabbits

Liang¹,

Niu²,

Wang³

et al. 2012

Afr. J. Biotechnol.

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To investigate whether protein (Pr) or calcium (Ca) supplementation could ameliorate hepatic damage induced by excessive fluoride (F); thirty-two 30-day-old healthy New Zealand rabbits were randomly divided into four groups (female: male = 1:1). The four groups were maintained on distilled water and fed the following diets for 120 days: (1) a malnutrition control (MC) diet (8.58% Pr, 0.49% Ca); (2) the MC diet plus HiF (high fluoride in their diet, 200 mg F ion/kg from NaF); (3) a Ca deficient MC diet plus HiPr+HiF (0.46% Ca, 18.41% Pr, plus HiF); and (4) a Pr deficient MC diet plus HiCa+HiF (2.23% Ca, 8.35% Pr, plus HiF). Results show that in HiF group, the serum total Pr (TPr) and albumin (ALB) content significantly decreased, whereas both Pr and Ca rich diets significantly enhanced their levels. In liver, low superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, high malondialdehyde (MDA) content, and evident mitochondria lesions in HiF group indicated a significant oxidative stress, while Pr or Ca supplementation brought an ultrastructural repair and a recovery antioxidant defense in liver. The findings in the present work implied the ameliorative effects of Pr or Ca supplementation on F-induced hepatotoxicity in rabbits.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Ameliorative effect of protein and calcium on fluoride-induced hepatotoxicity in rabbits

Liang¹,

Niu²,

Wang³

et al. 2012

Afr. J. Biotechnol.

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“…Together, these results show that dietary methionine deficiency induced a general mitochondrial defect in the liver of rainbow trout. At first sight, these results might seem surprising in the light of the numerous previous studies having demonstrated the antioxidant properties of methionine in several species including rainbow trout 39 – 44 . However, we cannot rule out the possibility of an increase of ROS production in methionine deficient condition earlier in the feeding trial that would induce the observed mitochondrial defects and the associated decrease of the oxidative status at 6 weeks.…”

Section: Discussionmentioning

confidence: 69%

Dietary methionine deficiency affects oxidative status, mitochondrial integrity and mitophagy in the liver of rainbow trout (Oncorhynchus mykiss)

Séité

Mourier

Camougrand

et al. 2018

Sci Rep

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The low levels of methionine in vegetable raw materials represent a limit to their use in aquafeed. Methionine is considered as an important factor in the control of oxidative status. However, restriction of dietary methionine has been shown to reduce generation of mitochondrial oxygen radicals and thus oxidative damage in liver. Here, we aim to evaluate the effect of dietary methionine deficiency in hepatic oxidative status in rainbow trout and identify the underlying mechanisms. Fish were fed for 6 weeks diets containing two different methionine concentrations: deficient (MD, Methionine Deficient diet) or adequate (CTL, control diet). At the end of the experiment, fish fed the MD diet showed a significantly lower body weight and feed efficiency compared to fish fed the CTL diet. Growth reduction of the MD group was associated to a general mitochondrial defect and a concomitant decrease of the oxidative status in the liver. The obtained results also revealed a sharp increase of mitochondrial degradation through mitophagy in these conditions and emphasized the involvement of the PINK1/PARKIN axis in this event. Collectively, these results provide a broader understanding of the mechanisms at play in the reduction of oxidant status upon dietary methionine deficiency.

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“…These effects have been observed in several soft tissues and cells, such as brain [21–26], gastrocnemius muscle [26], kidney [21, 23–25, 27–29], liver [19, 21, 23–25, 28, 30–32], heart [21], nervous system [33], blood [5, 25, 28, 34, 35], and osteoblasts [36, 37]. …”

Section: Introductionmentioning

confidence: 99%

Effects of Single Exposure of Sodium Fluoride on Lipid Peroxidation and Antioxidant Enzymes in Salivary Glands of Rats

Yamaguti

Simões

Ganzerla

et al. 2013

Oxidative Medicine and Cellular Longevity

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Many studies suggest that fluoride exposure can inhibit the activity of various enzymes and can generate free radicals, which interfere with antioxidant defence mechanisms in living systems. To further the understanding of this issue, this present study examined the effects of low-dose fluoride treatment on the activity of enzymatic antioxidant superoxide dismutase (SOD) and catalase (CAT), as well as the levels of lipid peroxidation (LPO) in the parotid (PA) and submandibular (SM) salivary glands of rats. Rats were injected with a single dose of sodium fluoride (NaF) (15 mg F−/kg b.w.) then euthanized at various time intervals up to 24 hours (h) following exposure. NaF exposure did not cause significant differences in SOD or CAT activity or LPO levels in PA glands compared to control. Conversely, SM glands presented increased SOD activity after 3 h and decreased SOD activity after 1, 12, and 24 h, while LPO was increased after 6, 12, and 24 h of the NaF injection. There were no significant differences in the CAT activity in the groups studied. Our results demonstrated that NaF intoxication caused oxidative stress in salivary glands few hours after administration. These changes were more pronounced in SM than in PA gland.

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Influence of Methionine on Toxicity of Fluoride in the Liver of Rats

Cited by 20 publications

References 31 publications

Ameliorative effect of protein and calcium on fluoride-induced hepatotoxicity in rabbits

Ameliorative effect of protein and calcium on fluoride-induced hepatotoxicity in rabbits

Dietary methionine deficiency affects oxidative status, mitochondrial integrity and mitophagy in the liver of rainbow trout (Oncorhynchus mykiss)

Effects of Single Exposure of Sodium Fluoride on Lipid Peroxidation and Antioxidant Enzymes in Salivary Glands of Rats

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