Influence of “Metisevit Plus” feed additive on morphological and biochemical parameters of bull blood under conditions of lead-cadmium loading

Slobodian, S. О.; Gutyj, B. V.; Shalovylo, S. H.; Golovach, P. I.; Pavliv, Oleksandra; Kalyn, B. M.; Kurtyak, B.M.; Hachak, Yuriy; Martyshuk, T. V.; Demus, N. V.; Шнайдер, В. Л.

doi:10.32718/nvlvet10609

Cited by 7 publications

(8 citation statements)

References 19 publications

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“…Надремонтний молодняк великої рогатої худоби в сучасних умовах ведення галузі скотарства при зменшенні потужності сільськогосподарських підприємств доцільно забезпечувати комфортними умовами утримання, годівлі та оцінкою витрат на виробництво яловичини енергоносіїв (Medved, 2012;Hryshchuk et al, 2021Hryshchuk et al, , 2022Slobodian et al, 2022;Smychok et al, 2023).…”

Section: вступunclassified

Modern methods of using industrial crossing, keeping conditions and obtaining additional energy carriers from purebred and crossbred animals

Zhelavskyi,

Marynenko,

Butkalyuk

2024

SMLNUVMBA

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This topic covers a wide range of aspects, including improving the genetic potential of animals through industrial crossbreeding, ensuring optimal housing conditions, and developing technologies for efficient use of the energy generated by these animals. Modern methods of industrial crossbreeding are determined by strategic plans to improve the genetic pool of animals to obtain more productive and disease-resistant offspring. Using advanced genetic technologies and modern breeding methods enhances product quality and ensures resistance to adverse factors. Considering the physiological needs of different breeds, providing appropriate nutrition and maintenance following current standards helps maintain high productivity and ensure the harmonious development of animals. In obtaining additional energy carriers, the latest technologies for using livestock waste in biogas, compost, and other energy resources are being studied. This contributes not only to the improvement of the environmental sustainability of farms but also to the use of internal resources for additional energy production. Summing up, modern approaches to the use of industrial crossing, housing conditions, and obtaining other energy carriers help solve complex tasks in animal husbandry, providing an optimal balance between productivity, efficiency, and environmental sustainability. It was established that the dynamics of live weight gains were more incredible in ½ Charolais steers when kept on deep litter, and on average up to 15 months, the average daily gains amounted to 947.9 g per day, and in purebreds under box keeping – 815.9 g; the absolute gains in live weight of purebred bulls of the Ukrainian black-spotted dairy breed, when kept in boxes for up to 15 months, reached 367.1 kg, which is 16.18 % less than that of ½ Charolais bulls when kept on deep bedding, with a probable difference of Р < 0.001. Innovative approaches to the use of the effect of heterosis and the conditions of keeping overrepair bulls in the production of beef have positive results, where ½ Charolais crossbreeds in conditions of keeping on deep bedding reach 453.9 kg by the age of 15 months, and their purebred counterparts – 406.7 kg, with a probable difference of P < 0.001. The results of the economic efficiency of the use of industrial crossbreeding, keeping conditions of purebred and crossbred bulls, show additional profits per head of 1,468.8 UAH ½ Charolais (maintenance on deep litter) and an increase in the level of profitability by 34.40 % compared to purebred Ukrainian black and white bulls dairy breed (maintenance boxing).

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Section: вступunclassified

Modern methods of using industrial crossing, keeping conditions and obtaining additional energy carriers from purebred and crossbred animals

Zhelavskyi,

Marynenko,

Butkalyuk

2024

SMLNUVMBA

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“…Імуностимулювальну дію розторопші плямистої проявляють флаволігнани об'єднані під загальною назвою -"Силімарин" (Gutyj et al, 2022. Це суміш трьох ізомерів: силібіліну, силікристину та силідіаніну (Slobodian et al, 2021(Slobodian et al, , 2022. Біологічна дія флаволігнанів на організм тварин і птиці досить різноманітна, і особливо важлива, гепатопротекторна і імуностимулювальна (Martyshuk et al, 2023).…”

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Definition of Acute Toxicity and Cumulative Properties of the Drug “Lipointersil”

Lavryshyn,

Gutyj,

Verveha

et al. 2023

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The research aimed to determine the acute toxicity and cumulative properties of the liposomal drug “Lipointersil” based on interferon and spotted milk thistle. The acute toxicity of the “Lipointersil” drug was assessed in white rats, aged 2–3 months, with a body weight of 170–180 g through intragastric and intramuscular administration. After administration of the drug, the dose and the number of animals that died were recorded, and the median lethal dose (DL50) of the investigated drug was calculated using the method of H. Kerber. The cumulative properties were determined in white rats aged 2–3 months, weighing 170–185 g, using the subchronic toxicity test method by K. S. Lim et al., modified by K. K. Sydorov. Based on the conducted research, it was established that the “Lipointersil”drug, according to the State Standard of Ukraine 85.2-37-736:2011, belongs to class IV toxicity (slightly toxic substances). The LD50 for intragastric and intramuscular administration in white rats is 5166.66 and 5833.33 mg/kg of body weight, respectively. In determining of the cumulative properties of the “ Lipointersil ” drug, no deaths of experimental animals were observed during the study. Moreover, the animals remained active, fed well, and had dense, shiny fur. The coefficient of accumulation of the “Lipointersil” drug was more than 8.31 units, indicating its weakly pronounced cumulative properties. Prolonged daily administration for 24 days of “Lipointersil” had no significant impact on the functional state of the liver and kidneys. Under long-term (24 days) daily administration in increasing doses, the drug “Lipointersil” caused slight destruction of hepatocyte membranes, as indicated by the increased activity of alanine and aspartate aminotransferases and alkaline phosphatase.

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“…Передусім антропогенний вплив людини призводить до забруднення довкілля ксенобіотиками, які є стійкими до впливу факторів зовнішнього середовища і відповідно володіють високою персистентністю, тому можуть долати довгі харчові ланцюги та призводити до порушення біологічних процесів і мікробіоценозів у ґрунті та водоймах. Основні ланки циркулювання токсичних речовин -це атмосфера, ґрунт, водойми, рослини, тварини (Zaritska et al, 2012;Bashchenko et al, 2020;Lavryshyn et al, 2020;Piven et al, 2020;Slobodian et al, 2021;Butsiak et al, 2021;Slobodian et al, 2022).…”

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Monitoring of the content of heavy metals in sunflower seeds and its processing products in Ukraine for 2018–2021

Shuliak¹,

Chechet²,

Haidei³

et al. 2022

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The article presents the results of research conducted at the State Research Institute of Laboratory Diagnostics and Veterinary-Sanitary Examination from 2018 to 2021 regarding the content of trace elements and toxic elements in sunflower seeds and their products of domestic production. During the studied period, 62 samples of sunflower seeds, 345 samples of sunflower meal, 289 samples of sunflower cake, and 68 samples of halva were analyzed. The preparation of samples was carried out by acid decomposition in nitric acid using a laboratory microwave system with closed-type autoclaves. The content of Lead, Cadmium, and Arsenic was determined by the method of atomic absorption spectrometry with electrothermal atomization and background correction with the Zeiman effect. The content of copper and zinc was determined by atomic absorption spectrometry with flame atomization with deuterium background correction. Mercury content – by the direct method of atomic absorption spectrometry. In all studied samples, the content of copper varied between 1.21–42.9 mg/kg, the content of zinc 17.7–75.40 mg/kg, the content of lead 0.011–1.121 mg/kg, the content of arsenic 0.0035–0.004 mg/kg, Mercury 0.005–0.051 mg/kg. The results of studies of sunflower seeds and halva for cadmium content were in the range of 0.052–0.234 mg/kg and 0.080–0.271 mg/kg. According to the obtained results, it was established that cadmium content exceeded the maximum permissible level value in five sunflower seeds and in eighteen halva samples, which is 2.7 % and 20.2 % of the total amount of the studied material. During the study of the content of inorganic pollutants Lead, Arsenic, Zinc, and Copper in sunflower seeds and halva, no violations of the maximum permissible levels were found. Regarding the analysis of meal and sunflower cake for the content of Cadmium, Lead, Arsenic, Copper, and Zinc, no violations of the MDR were detected. The contamination of seeds and halva with cadmium exceeded the legally permissible levels by 1.1 to 2.1 times. These results confirm literature data on the ability of sunflowers to accumulate cadmium, particularly in seeds. The analysis of the work demonstrates the need for more thorough and systematic control of sunflower raw materials both at the growing stage and in the process of harvesting, drying, and processing at various stages of feed and final product production.

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Influence of “Metisevit Plus” feed additive on morphological and biochemical parameters of bull blood under conditions of lead-cadmium loading

Cited by 7 publications

References 19 publications

Modern methods of using industrial crossing, keeping conditions and obtaining additional energy carriers from purebred and crossbred animals

Modern methods of using industrial crossing, keeping conditions and obtaining additional energy carriers from purebred and crossbred animals

Definition of Acute Toxicity and Cumulative Properties of the Drug “Lipointersil”

Monitoring of the content of heavy metals in sunflower seeds and its processing products in Ukraine for 2018–2021

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