Influence of Micro-RNA-423 Gene Variation on Risk and Characteristics of Breast Cancer

El-Ashry, Amira H.; Albeltagy, Ahmed Mamdouh Gaber; Ramez, Ahmed; Hendawy, Shimaa R.

doi:10.31557/apjcp.2022.23.11.3771

Cited by 3 publications

(1 citation statement)

References 26 publications

(26 reference statements)

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“…In breast cancer, studies reporting the association between rs6505162 and cancer risk have come to contradictory conclusions. Smith et al showed that the CC genotype was linked to a reduced risk of breast cancer in Caucasian women (odds ratio, OR = 0.50; p = 0.03) [42], and the A allele was reported as a risk factor in the pathogenesis of breast cancer among the Egyptian population (OR = 3.28, p = 0.002; OR = 2.11, p = 0.011; for AA and CA against CC patients, respectively) [43]. In contrast, the CC genotype of rs6506162 was reported to be associated with an increased risk of breast cancer in Iranian women (OR = 2.37; p = 0.0023) [44].…”

Section: Discussionmentioning

confidence: 99%

Genetic Regulation of Human isomiR Biogenesis

Jiang,

Reiter,

Dong

et al. 2023

Cancers

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MicroRNAs play a critical role in regulating gene expression post-transcriptionally. Variations in mature microRNA sequences, known as isomiRs, arise from imprecise cleavage and nucleotide substitution or addition. These isomiRs can target different mRNAs or compete with their canonical counterparts, thereby expanding the scope of miRNA post-transcriptional regulation. Our study investigated the relationship between cis-acting single-nucleotide polymorphisms (SNPs) in precursor miRNA regions and isomiR composition, represented by the ratio of a specific 5′-isomiR subtype to all isomiRs identified for a particular mature miRNA. Significant associations between 95 SNP–isomiR pairs were identified. Of note, rs6505162 was significantly associated with both the 5′-extension of hsa-miR-423-3p and the 5′-trimming of hsa-miR-423-5p. Comparison of breast cancer and normal samples revealed that the expression of both isomiRs was significantly higher in tumors than in normal tissues. This study sheds light on the genetic regulation of isomiR maturation and advances our understanding of post-transcriptional regulation by microRNAs.

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Section: Discussionmentioning

confidence: 99%

Genetic Regulation of Human isomiR Biogenesis

Jiang,

Reiter,

Dong

et al. 2023

Cancers

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Genetic regulation of human isomiR biogenesis

Jiang¹,

Reiter²,

Dong³

et al. 2023

Preprint

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MicroRNA plays a critical role in regulating gene expression post-transcriptionally. Variations in mature microRNA sequences, known as isomiRs, arise from imprecise cleavage and nucleotide substitution or addition. These isomiRs can target different mRNAs or compete with their canonical counterparts, thereby expanding the scope of miRNA post-transcriptional regulation. Our study investigated the relationship between cis-acting single nucleotide polymorphisms (SNPs) in precursor miRNA regions and isomiR composition, represented by the ratio of a specific 5’-isomiR subtype to all isomiRs identified for a particular mature miRNA. Significant associations between 95 SNP-isomiR pairs were identified. Of note, rs6505162 was significantly associated with both 5’-extension of hsa-miR-423-3p and 5’-trimming of hsa-miR-423-5p. Comparison of breast cancer and normal samples revealed that expression of both isomiRs was significantly higher in tumors than in normal tissues. This study sheds light on the genetic regulation of isomiR maturation and advances our understanding of post-transcriptional regulation by microRNA.

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Genetic Variation in Microrna-423 and Microrna 137 Genes among Patients with Breast Cancer

Madhloom

2024

JPDMHD

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Aim MicroRNAs (miRNAs) are a family of non-coding RNAs that have been suggested as novel markers or therapeutic targets for breast cancer. In current study, we aimed to investigate the prevalence of microRNA-423 rs6505162C/T and the VNTR length of the MIR 137 gene (rs58335419) with regards to breast cancer susceptibility in Iraqi women. Methods: In this study, 190 individuals took part, out of which 110 were breast cancer patients and 80 were healthy controls. The amplification refractory mutation system PCR method (ARMS-PCR) was used to determine the polymorphism in the microRNA-423 (rs6505162) gene. While the VNTR length of the MIR 137 gene (rs58335419) was identified using PCR. The Graph Pad Prism 9 software was used to conduct the statistical analysis. Results: the allele frequency of T in the microRNA-423 rs6505162 was significantly associated with breast cancer (odds ratio [95% confidence interval] 2.333 [1.519-3.600], Risk factor [95% confidence interval]) 1.400 [1.184-1.655], p < 0.0001). On the other hand, all the allele frequencies in the MIR 137 gene (rs58335419) were not found to be associated with breast cancer. Conclusion: Based on the results, the study suggests that microRNA-423 rs6505162C/T could be useful markers for diagnosing breast cancer, whereas the MIR 137 gene (rs58335419) is not useful for diagnosing breast cancer.

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Influence of Micro-RNA-423 Gene Variation on Risk and Characteristics of Breast Cancer

Cited by 3 publications

References 26 publications

Genetic Regulation of Human isomiR Biogenesis

Genetic Regulation of Human isomiR Biogenesis

Genetic regulation of human isomiR biogenesis

Genetic Variation in Microrna-423 and Microrna 137 Genes among Patients with Breast Cancer

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