Influence of Microorganisms on Intestinal Absorption: Oleic Acid 131I and Triolein 131I Absorption by Germfree and Conventionalized Rats

Tennant, Bud C.; Reina-Guerra, M; Harrold, D; Goldman, Marvin

doi:10.1093/jn/97.1.65

Cited by 16 publications

(3 citation statements)

References 13 publications

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“…Studies on germ-free and conventional rats and chicks have shown that the intestinal microflora also interferes with absorption of fats Eyssen & De Somer, 1967). Lipolysis, however, does not seem to be significantly affected by the gut microflora Tennant, Reina-Guerra, Harrold & Goldman, 1969).…”

Section: Fatty Acidsmentioning

confidence: 82%

Role of the gut microflora in metabolism of lipids and sterols

Eyssen

1973

Proc. Nutr. Soc.

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Section: Fatty Acidsmentioning

confidence: 82%

Role of the gut microflora in metabolism of lipids and sterols

Eyssen

1973

Proc. Nutr. Soc.

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“…The influence of intestinal bacteria on the absorption and metabolism offoreign compounds germ-free animals decreases the rate of absorption of water; absorption of foodstuffs is also affected but the changes appear to be species linked (Cole, 1967;Geever, Kan, and Levenson, 1968;Gordon, 1969;Tennant, Reina-Guerra, Harrold, and Goldman, 1969;Wiech, 1969). Products of bacterial metabolism are also absorbed from the intestine.…”

Section: The Effect Of Bacteria On Mucosal Structure and Functionsmentioning

confidence: 99%

The influence of intestinal bacteria on the absorption and metabolism of foreign compounds

Williams¹,

Hill²,

Drašar³

1971

Journal of Clinical Pathology

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“…The rate of disappearance of ['4C]choleragen from closed loops of intestine in germfree rats was determined to ascertain if the intestinal microflora in conventional rats can alter choleragen and hence change its rate of disappearance. Fisher germfree rats were bred and raised using germfree equipment and germfree methods described previously (17). The protocol used in the germfree rats was the same as that used for conventional rats.…”

mentioning

confidence: 99%

Comparison of the rate of absorption and proteolysis of [14C]choleragen and [14C]bovine serum albumin in the rat jejunum

Strombeck¹,

Harrold²

1975

Infect Immun

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['4C]choleragen was used to study the rate of disappearance of choleragen enterotoxin from the jejunum of rats. [14C]bovine serum albumin (BSA) was studied in a similar manner. Almost one-third of the labeled toxin had disappeared from the intestine after 6 h. Its rate of disappearance was the same in germfree rats as in conventional rats. The rate of proteolysis of ['4C]choleragen and ['4C]BSA by intestinal mucosal lysosomal enzymes was also studied. Neither was significantly degraded by neutral proteases; however, heat-inactivated toxin was. They were all degraded by acid proteases; however, the rate of BSA proteolysis was only one-third of that of toxin. Soybean trypsin inhibitor had no effect on the in vivo disappearance of toxin nor on the acid proteases. It did inhibit the neutral protease digestion of heat-treated toxin. Apirotinin and protamine inhibited disappearance in loops of gut but had no effect to inhibit degradation rates. Gangliosides inhibited both rates of disappearance and proteolysis of toxin. These agents had some different effects on disappearance rates and proteolysis of BSA. The data indicate that cholera enterotoxin is absorbed by intestinal mucosal cells and is degraded by acid proteases in the cells.

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Influence of Microorganisms on Intestinal Absorption: Oleic Acid 131I and Triolein 131I Absorption by Germfree and Conventionalized Rats

Cited by 16 publications

References 13 publications

Role of the gut microflora in metabolism of lipids and sterols

Role of the gut microflora in metabolism of lipids and sterols

The influence of intestinal bacteria on the absorption and metabolism of foreign compounds

Comparison of the rate of absorption and proteolysis of [14C]choleragen and [14C]bovine serum albumin in the rat jejunum

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