Influence of moderate physical exercise on insulin-mediated and non—insulin-mediated glucose uptake in healthy subjects

Araújo‐Vilar, David; Osifo, Egbe; Kirk, M.; García-Estévez, D A; Cabezas-Cerrato, J; Hockaday, T. D. R.

doi:10.1016/s0026-0495(97)90303-6

Cited by 21 publications

(12 citation statements)

References 33 publications

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“…(2007) assessed insulin action during a euglycaemic‐hyperinsulinaemic clamp (EHC) with a steady‐state serum insulin concentration of approximately 275–290 mu/l. In contrast, similar to previous studies in man (Araújo‐Vilar et al . 1997; Arciero et al .…”

Section: Discussionsupporting

confidence: 93%

“…Pratt et al (2007) assessed insulin action during a euglycaemichyperinsulinaemic clamp (EHC) with a steady-state serum insulin concentration of approximately 275-290 mu/l. In contrast, similar to previous studies in man (Araújo-Vilar et al 1997;Arciero et al 1999), the present study employed a hyperglycaemic clamp at physiological hyperinsulinaemia (60-65 mu/l). In man, there is an approximately linear increase in glucose uptake from plasma as steady-state insulin concentration is increased from 20 mu/l to about 100 mu/l, reaching an asymptote at supraphysiological insulin concentrations (150-350 mu/l).…”

Section: Discussionmentioning

confidence: 99%

“…Hyperglycaemic clamps were performed during physiological hyperinsulinaemia (insulin concentration approximately 60–70 mu/l) and during somatostatin‐induced insulinopenia (<10 mu/l) to measure IMGU and NIMGU, respectively (Baron et al . 1988; Araújo‐Vilar et al . 1997).…”

Section: Introductionmentioning

confidence: 99%

“…The objective of the study reported here was to determine the effects of a single bout of moderate-intensity exercise on measures of IMGU and NIMGU in horses during hyperglycaemia. Hyperglycaemic clamps were performed during physiological hyperinsulinaemia (insulin concentration approximately 60-70 mu/l) and during somatostatin-induced insulinopenia (<10 mu/l) to measure IMGU and NIMGU, respectively (Baron et al 1988;Araújo-Vilar et al 1997). It was hypothesised that prior exercise would increase both IMGU and NIMGU under hyperglycaemic conditions.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of prior exercise on insulin‐mediated and noninsulin‐mediated glucose uptake in horses during a hyperglycaemic clamp

Geor¹,

Stewart-Hunt

McCutcheon

2010

Equine Veterinary Journal

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of prior exercise on insulin‐mediated and noninsulin‐mediated glucose uptake in horses during a hyperglycaemic clamp

Geor¹,

Stewart-Hunt

McCutcheon

2010

Equine Veterinary Journal

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“…As PCOS is often associated with obesity, concomitant insulin resistance, and hyperinsulinemia, weight reduction and lifestyle change are considered important in overweight women with PCOS with anovulatory infertility . Weight reduction reduces hyperinsulinemia and insulin resistance, and increased physical activity increases insulin sensitivity . This improves the hormonal imbalance in the ovary and reduces androgen dominance .…”

Section: Resultsmentioning

confidence: 99%

Ovulation induction in polycystic ovary syndrome

Tanbo

Mellembakken

Bjercke

et al. 2018

Acta Obstet Gynecol Scand

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The objective of this narrative review was to suggest a rational order of treatment choices in anovulatory women with polycystic ovary syndrome (PCOS), for whom a multitude of treatment options exist. In obese/overweight women with PCOS the importance of weight reduction should be stressed. Inositol, a dietary supplement with a documented effect on ovulation and without adverse effects in the doses recommended, may be suggested. Additional first-line medical alternatives include insulin sensitizers, selective estrogen receptor modulators, and aromatase inhibitors. Of these, the aromatase inhibitor letrozole and the combination of clomiphene citrate and metformin have the highest rates of ovulation and live birth. Second-line treatments are ovarian electrocautery and low-dose follicle-stimulating hormone stimulation. Controlled ovarian stimulation with in vitro fertilization, should be considered the last option as it carries a significant risk of ovarian hyperstimulation syndrome in patients with PCOS.

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Effect of long-term strength training on glucose metabolism. Implications for individual impact of high lean mass and high fat mass on relationship between BMI and insulin sensitivity

Gippini¹,

Mato²,

Pazos³

et al. 2002

J Endocrinol Invest

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The aim of this study was to examine the independent effect of high lean mass on glucose metabolism, as well as its consequences on the classic relationship between BMI and insulin sensitivity (SI) in 3 groups: 1) 8 strength-trained males with BMI >27 kg/m2 (athletes); 2) 10 sedentary males with BMI >27 kg/m2 (obese); and 3) 12 sedentary males with BMI 22-25 kg/m2 (control). Body composition was measured with impedance analysis. Iv glucose tolerance test was performed at 09:00 h after overnight fast. Estimation of insulin sensitivity and glucose effectiveness by Minimal Model Approach. Plasma glucose and insulin determination by glucose-oxidase and RIA respectively. BMI and lean mass (LM) were greater in athletes than in controls, but there were no differences in fat mass (FM), basal glucose (Gb), basal insulin (Ib), glucose tolerance (Kg), SI, glucose effectiveness (Sg), acute insulin response to glucose (AIRG) and leptin. Obese showed greater FM, leptin, lb and AIRG than athletes, while SI was lower; BMI, LM, Gb, Kg and Sg were similar. BMI, FM, LM, Ib, AIRG and leptin were lower in controls than in obese, while SI index was greater; Gb, Sg and Kg were similar. We found that: 1) Resistance exercise does not modify glucose effectiveness, but can improve insulin sensitivity through FM reduction (LM augmentation alone has no effect on glucose metabolism); and 2) High BMI causes insulin resistance only if it depends on adipose tissue hypertrophy.

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Influence of moderate physical exercise on insulin-mediated and non—insulin-mediated glucose uptake in healthy subjects

Cited by 21 publications

References 33 publications

Effects of prior exercise on insulin‐mediated and noninsulin‐mediated glucose uptake in horses during a hyperglycaemic clamp

Effects of prior exercise on insulin‐mediated and noninsulin‐mediated glucose uptake in horses during a hyperglycaemic clamp

Ovulation induction in polycystic ovary syndrome

Effect of long-term strength training on glucose metabolism. Implications for individual impact of high lean mass and high fat mass on relationship between BMI and insulin sensitivity

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