Influence of Moxifloxacin on Hepatic Redox Status and Plasma Biomarkers of Hepatotoxicity and Nephrotoxicity in Rat

Abstract

Moxifloxacin is a broad spectrum fluoroquinolone antibacterial agent. We examined the hepatic redox status and plasma biomarkers of nephrotoxicity and hepatotoxicity in rat following administration of moxifloxacin (MXF). Twenty-four Wistar rats, 180–200 g, were randomized into four groups (I–IV). Animals in group I (control) received 1 mL of distilled water, while animals in groups II, III, and IV received 1 mL each of MXF equivalent to 4 mg/kg b.w., 8 mg/kg b.w., and 16 mg/kg b.w., respectively. After seven days, plasma urea, bilirubin, and creatinine were significantly (P < 0.05) elevated in the MXF-treated animals. Activities of alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase were significantly increased in the plasma of MXF-treated animals compared to control. Also plasma total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides increased significantly in the MXF-treated groups relative to control. Moreover, MXF triggered a significant decrease in hepatic catalase, superoxide dismutase, and glutathione-S transferase activities. Likewise, MXF caused a decrease in the hepatic levels of glutathione and vitamin C. A significant increase in hepatic MDA content was also observed in the MXF-treated animals relative to control. Overall, our data suggest that the half-therapeutic, therapeutic, and twice the therapeutic dose of MXF induced nephrotoxicity, hepatotoxicity, and altered hepatic redox balance in rats.

Assessment of Ackee Apple (Blighia Sapida) on Cholinergic and Antioxidant Enzymes; Possible Use of the Plant Stem-Bark Extract as a Biological Pest Controlling Agent

“…Plasma alkaline phosphatase is one of the liver biomarker enzymes, whose evaluation provides details of pathological damage to the tissue (Mu'azu et al, 2020). A high level of plasma ALP activity has been linked with hepatobiliary dysfunction which is likely a result of hepatobiliary injury and cholestasis (Ore and Olayinka, 2015). The nonsignificant value of ALP activities observed in this study implied that the doses of the extract considered may not affect the hepatobiliary function of the liver.…”

Serum Metabolic Characterization of Vitamin E Deficiency in Holstein Cows during the Transition Period Based on Proton Nuclear Magnetic Resonance Spectroscopy

“…It was hypothesized that VED stimulated the β-oxidation of fatty acids since there was an elevation in the concentrations of acetone. In addition, the level of lipid peroxidation and lipid peroxidation byproducts that are generated is directly proportional to the amount of unsaturated fats [ 51 ]. The results of the present study confirmed this, with higher serum concentrations of unsaturated lipids (L7, L8, L9) and MDA in VED cows.…”

Adverse effects of moxifloxacin and flunixin meglumine and their combination on pregnant rats

“…The GSH level in the liver is a measure of non-enzymatic anti-oxidant and cellular Redox Status of the cells [22] The observed reduction in GSH levels are in accordance with the previously recorded data by many fluoroquinolones [23] . Also, quinolones have the capacity to produce free radicals and change the activity of antioxidant enzymes [24].Moreover, [25] said that, gatifloxacin significantly decreased the activity of superoxide dismutase and blood glutathione levels of treated rabbits. In addition [26].…”